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Acta Mechanica Sinica
Published in: Acta Mechanica Sinica 4/2020

25-07-2020 | Research Paper

Multi-scale mechanotransduction of the poroelastic signals from osteon to osteocyte in bone tissue

Authors: Xiaogang Wu, Chaoxin Li, Kuijun Chen, Yuqin Sun, Weilun Yu, Meizhen Zhang, Yanqin Wang, Yixian Qin, Weiyi Chen

Published in: Acta Mechanica Sinica | Issue 4/2020

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Abstract

In order to quantify the poroelastic mechanical signals conduction and evaluate the biomechanical effectiveness of functional units (osteocyte processes, canaliculi and lacuna) in lacunar-canalicular system (LCS), a multiscale poroelastic finite element model was established by using the Comsol Multiphysics software. The poroelastic mechanical signals (pore pressure, fluid velocity, von-Mises stress, strain) were analyzed inside the osteon-osteocyte system. The effects of osteocyte (OCY)’s shape (ellipse and circle), long axis directions (horizontal and vertical) and mechanical properties (Elastic modulus and permeability) on its poroelastic responses were examined. It is found that the OCY processes is the best mechanosensor compared with the OCY body, lacunae and canaliculi. The mechanotransduction ability of the elliptic shaped OCY is stronger than that of circular shaped. The pore pressure and flow velocity around OCYs increase as the elastic modulus and permeability of OCY increase. The established model can be used for studying the mechanism of bone mechanotransduction at the multiscale level.

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Metadata
Title
Multi-scale mechanotransduction of the poroelastic signals from osteon to osteocyte in bone tissue
Authors
Xiaogang Wu
Chaoxin Li
Kuijun Chen
Yuqin Sun
Weilun Yu
Meizhen Zhang
Yanqin Wang
Yixian Qin
Weiyi Chen
Publication date
25-07-2020
Publisher
The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences
Published in
Acta Mechanica Sinica / Issue 4/2020
Print ISSN: 0567-7718
Electronic ISSN: 1614-3116
DOI
https://doi.org/10.1007/s10409-020-00975-y

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