Skip to main content
Disciplines
Automotive Business IT + Informatics Construction + Real Estate Electrical Engineering + Electronics Energy + Sustainability Insurance + Risk Finance + Banking Management + Leadership Marketing + Sales Mechanical Engineering + Materials
Events
DE
EN
Books
Journals
Topic Page
Marketing
Start single access now
Access for companies
EXTENDED SEARCH
Log in
Top
Published in:
Integrated Thermal Flow Sensors with Programmable Power-Sensitivity Trade-Off Read chapter Read first chapter

2018 | OriginalPaper | Chapter

Multianalyte Biosensor Patch Based on Polymeric Microneedles

Authors : P. Dardano, A. Caliò, V. Di Palma, M. F. Bevilacqua, A. Di Matteo, L. De Stefano

Published in: Sensors

Publisher: Springer International Publishing

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Multianalyte biosensor patch based on polymeric microneedles (MNs) have been fabricated by photolithography of poly (ethylene glycol) diacrylate (PEGDA) and have been dynamically characterized by means of quartz crystal microbalance and electrochemical measurements. The resulting flexible device acts as multianalyte working electrodes detecting glucose and lactic acid into interstitial liquid by means of redox reaction with glucose oxidase (GOx) and lactose oxidase (LOx) enzymes. Sensitivities of the order of nA mM−1 in the mM range are revealed in both case, after five minutes of swelling time and ten second of interaction.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

inform now
previous chapter Iron Oxides Nanoparticles Langmuir-Schaeffer Multilayers for Chemoresistive Gas Sensing
next chapter Effective Tuning of Silver Decorated Graphene Sensing Properties by Adjusting the Ag NPs Coverage Density
Literature
1.
J. Wang, Electrochemical glucose biosensors. Chem. Rev. 108(2), 814–825 (2008)CrossRef
2.
N. Nikolaus, B. Strehlitz, Amperometric lactate biosensors and their application in (sports) medicine, for life quality and wellbeing. Microchim. Acta 160(1–2), 15–55 (2008)CrossRef
3.
L. Ventrelli, L.M. Strambini, G. Barillaro, Microneedles for transdermal biosensing: current picture and future direction. Adv. Healthc. Mater. (2015). doi:10.​1002/​adhm.​201500450
4.
A. Caliò et al., “Polymeric microneedles based enzymatic electrodes for electrochemical biosensing of glucose and lactic acid.” Sens. Actuators B: Chem. 236, 343–349 (2016)
5.
P. Dardano et al., “Optically monitored drug delivery patch based on porous silicon and polymer microneedles.” Biomed Opt. Express. 7(5), 1645–1655 (2016)
6.
Gabriela Valdés-Ramíreza et al., Multiplexed and switchable release of distinct fluids from microneedle platforms via conducting polymer nanoactuators for potential drug delivery. Sens. Actuators B: Chem. 161(1), 1018–1024 (2012)CrossRef
7.
J. Yan et al., Immobilizing enzymes onto electrode arrays by hydrogel photolithography to fabricate multi-analyte electrochemical biosensors. ACS Appl. Mater. Interfaces 2(3), 748–755 (2010)MathSciNetCrossRef
8.
P. Dardano et al., A photolithographic approach to polymeric microneedles array fabrication. Materials, 8(12), 8661–8673 (2015). doi:10.​3390/​ma8125484
9.
C. Nicolini et al., High-sensitivity biosensor based on LB technology and on nanogravimetry. Sens. Actuators B Chem. 24, 121–128 (1995)CrossRef
10.
R. Spera et al., NAPPA based nanogravimetric biosensor: preliminary characterization. Sens. Actuators B 182, 682–688 (2013)CrossRef
11.
T. Bezerra Correia, V. Bavastrello, C. Nicolini, Calcium oxide matrices and carbon dioxide sensors. Sensors (Basel) 12, 5896–5905 (2012)CrossRef
12.
N.Y. Shim, D.A. Bernards, D.J. Macaya, J.A. DeFranco, M. Nikolou, R.M. Owens, G.G. Malliaras, All-plastic electrochemical transistor for glucose sensing using a ferrocene mediator. Sensors 9(12), 9896–9902 (2009)CrossRef
13.
N. Thomas, I. Lähdesmäki, B.A. Parviz, A contact lens with an integrated lactate sensor. Sens. Actuators B: Chem. 162(1), 128–134 (2012)CrossRef
14.
L. Strambini, A. Longo, S. Scarano, T. Prescimone, I. Palchetti, M. Minunni, D. Giannessi, G. Barillaro, Biosens. Bioelectron. 66, 162 (2015)CrossRef
15.
V. Di Palma, M.F. Bevilacqua, A. Di Matteo, P. Dardano, Microneedle array device for biosensor applications. US Application Patent 14558779
Metadata
Title
Multianalyte Biosensor Patch Based on Polymeric Microneedles
Authors
P. Dardano
A. Caliò
V. Di Palma
M. F. Bevilacqua
A. Di Matteo
L. De Stefano
Copyright Year
2018
Book
Sensors

Print ISBN: 978-3-319-55076-3

Electronic ISBN: 978-3-319-55077-0

Copyright Year: 2018

DOI
https://doi.org/10.1007/978-3-319-55077-0_10