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In Vivo, In Vitro, In Silico: Computational Tools for Product and Process Design in Tissue Engineering Read chapter Read first chapter

2013 | OriginalPaper | Chapter

Multiphysics Computational Modeling in Cartilage Tissue Engineering

Authors : Manuela Teresa Raimondi, Paola Causin, Matteo Laganà, Paolo Zunino, Riccardo Sacco

Published in: Computational Modeling in Tissue Engineering

Publisher: Springer Berlin Heidelberg

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Abstract

A common technique for in vitro cartilage regeneration is to seed a porous matrix with cartilage cells and to culture the construct in static conditions or under medium perfusion in a bioreactor. An essential step toward the development of functional cartilage is to understand and control the tissue growth phenomenon in such systems. The growth process depends on various space- and time-varying biophysical variables of the environment surrounding the cartilage cells, primarily mass transport and mechanical variables, all involved in the cell biological response. Moreover, the growth process is inherently multiscale, since cell size (10 μm), scaffold pore size (100 μm), and cellular construct size (10 mm) pertain to three separate spatial scales. To obtain a quantitative understanding of cartilage growth in this complex multiphysics and multiscale system, advanced mathematical models and efficient scientific computing techniques have been developed. In this chapter, we discuss the existing knowledge in this field and we present the most recent advancements for the numerical simulation of cartilage tissue engineering.

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previous chapter Continuum Modelling of In Vitro Tissue Engineering: A Review
next chapter Oxygen Transport in Bioreactors for Engineered Vascular Tissues
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Metadata
Title
Multiphysics Computational Modeling in Cartilage Tissue Engineering
Authors
Manuela Teresa Raimondi
Paola Causin
Matteo Laganà
Paolo Zunino
Riccardo Sacco
Copyright Year
2013
Publisher
Springer Berlin Heidelberg
Book
Computational Modeling in Tissue Engineering

Print ISBN: 978-3-642-32562-5

Electronic ISBN: 978-3-642-32563-2

Copyright Year: 2013

DOI
https://doi.org/10.1007/8415_2011_112