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2020 | OriginalPaper | Chapter

13. Nanozyme-Based Tumor Theranostics

Authors : Xiangqin Meng, Lizeng Gao, Kelong Fan, Xiyun Yan

Published in: Nanozymology

Publisher: Springer Singapore

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Abstract

Enzyme mimetic activities of nanozymes have substantially expanded the applications of nanomaterials in medicine. By using the peroxidase-like activity of nanozymes to catalyze the oxidation of substrates producing a color reaction, researchers were able to develop various in vitro tumor diagnosis methods. Meanwhile, the capacity of nanozymes to alter redox potential can be employed to impair the in vivo homeostasis of tumor cells by generating toxic-free radicals in tumor therapy. In addition, the catalytical decomposition of tumor metabolic products by nanozymes also benefits the tumor imaging or tumor therapy. In this chapter, we will systematically summarize the reported applications of nanozymes in the field of tumor theranostics and discuss the potential clinical practices based on nanozyme in the near future.

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Literature
11.
go back to reference Dugan LL, Tian LL, Quick KL, Hardt JI, Karimi M, Brown C, Loftin S, Flores H, Moerlein SM, Polich J, Tabbal SD, Mink JW, Perlmutter JS (2014) Carboxyfullerene neuroprotection postinjury in parkinsonian nonhuman primates. Ann Neurol 76(3):393–402. https://doi.org/10.1002/ana.24220CrossRef Dugan LL, Tian LL, Quick KL, Hardt JI, Karimi M, Brown C, Loftin S, Flores H, Moerlein SM, Polich J, Tabbal SD, Mink JW, Perlmutter JS (2014) Carboxyfullerene neuroprotection postinjury in parkinsonian nonhuman primates. Ann Neurol 76(3):393–402. https://​doi.​org/​10.​1002/​ana.​24220CrossRef
12.
go back to reference Linehan WM, Bratslavsky G, Pinto PA, Schmidt LS, Neckers L, Bottaro DP, Srinivasan R (2010) Molecular diagnosis and therapy of kidney cancer. Annu Rev Med 61:329–343CrossRef Linehan WM, Bratslavsky G, Pinto PA, Schmidt LS, Neckers L, Bottaro DP, Srinivasan R (2010) Molecular diagnosis and therapy of kidney cancer. Annu Rev Med 61:329–343CrossRef
15.
go back to reference He XW, Ma N (2014) A general strategy for label-free sensitive DNA detection based on quantum dot doping. Anal Chem 86(7):3676–3681CrossRef He XW, Ma N (2014) A general strategy for label-free sensitive DNA detection based on quantum dot doping. Anal Chem 86(7):3676–3681CrossRef
17.
go back to reference Paul A, Paul S (2014) The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers. Front Biosci-Landmrk 19(4):605–618CrossRef Paul A, Paul S (2014) The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers. Front Biosci-Landmrk 19(4):605–618CrossRef
18.
go back to reference Kulasingam V, Diamandis EP (2008) Strategies for discovering novel cancer biomarkers through utilization of emerging technologies. Nat Clin Pract Oncol 5(10):588–599CrossRef Kulasingam V, Diamandis EP (2008) Strategies for discovering novel cancer biomarkers through utilization of emerging technologies. Nat Clin Pract Oncol 5(10):588–599CrossRef
27.
go back to reference Gao L, Liu M, Ma G, Wang Y, Zhao L, Yuan Q, Gao F, Liu R, Zhai J, Chai Z, Zhao Y, Gao X (2015) Peptide-conjugated gold nanoprobe: intrinsic nanozyme-linked immunsorbant assay of integrin expression level on cell membrane. ACS Nano 9(11):10979–10990CrossRef Gao L, Liu M, Ma G, Wang Y, Zhao L, Yuan Q, Gao F, Liu R, Zhai J, Chai Z, Zhao Y, Gao X (2015) Peptide-conjugated gold nanoprobe: intrinsic nanozyme-linked immunsorbant assay of integrin expression level on cell membrane. ACS Nano 9(11):10979–10990CrossRef
28.
go back to reference Bramwell VHC, Doig GS, Tuck AB, Wilson SM, Tonkin KS, Tomiak A, Perera F, Vandenberg TA, Chambers AF (2009) Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer. Breast Cancer Res Tr 114(3):503–511CrossRef Bramwell VHC, Doig GS, Tuck AB, Wilson SM, Tonkin KS, Tomiak A, Perera F, Vandenberg TA, Chambers AF (2009) Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer. Breast Cancer Res Tr 114(3):503–511CrossRef
29.
go back to reference Estrela JM, Ortega A, Obrador E (2006) Glutathione in cancer biology and therapy. Crit Rev Cl Lab Sci 43(2):143–181CrossRef Estrela JM, Ortega A, Obrador E (2006) Glutathione in cancer biology and therapy. Crit Rev Cl Lab Sci 43(2):143–181CrossRef
30.
go back to reference Ma YH, Zhang ZY, Ren CL, Liu GY, Chen XG (2012) A novel colorimetric determination of reduced glutathione in A549 cells based on Fe3O4 magnetic nanoparticles as peroxidase mimetics. Analyst 137(2):485–489CrossRef Ma YH, Zhang ZY, Ren CL, Liu GY, Chen XG (2012) A novel colorimetric determination of reduced glutathione in A549 cells based on Fe3O4 magnetic nanoparticles as peroxidase mimetics. Analyst 137(2):485–489CrossRef
31.
go back to reference Gao J, Guo ZK, Su FJ, Gao L, Pang XH, Cao W, Du B, Wei Q (2015) Ultrasensitive electrochemical immunoassay for CEA through host-guest interaction of beta-cyclodextrin functionalized graphene and Cu@Ag core-shell nanoparticles with adamantine-modified antibody. Biosens Bioelectron 63:465–471CrossRef Gao J, Guo ZK, Su FJ, Gao L, Pang XH, Cao W, Du B, Wei Q (2015) Ultrasensitive electrochemical immunoassay for CEA through host-guest interaction of beta-cyclodextrin functionalized graphene and Cu@Ag core-shell nanoparticles with adamantine-modified antibody. Biosens Bioelectron 63:465–471CrossRef
32.
go back to reference Xu YS, Zhang XP, Luan CX, Wang H, Chen BA, Zhao YJ (2017) Hybrid hydrogel photonic barcodes for multiplex detection of tumor markers. Biosens Bioelectron 87:264–270CrossRef Xu YS, Zhang XP, Luan CX, Wang H, Chen BA, Zhao YJ (2017) Hybrid hydrogel photonic barcodes for multiplex detection of tumor markers. Biosens Bioelectron 87:264–270CrossRef
33.
go back to reference Ylanne J, Cheresh DA, Virtanen I (1990) Localization of Beta-1-Subunit, Beta-3-Subunit, Alpha-5-Subunit, Alpha-V-Subunit and Alpha-Iib-Subunit of the integrin family in spreading human erythroleukemia-cells. Blood 76(3):570–577CrossRef Ylanne J, Cheresh DA, Virtanen I (1990) Localization of Beta-1-Subunit, Beta-3-Subunit, Alpha-5-Subunit, Alpha-V-Subunit and Alpha-Iib-Subunit of the integrin family in spreading human erythroleukemia-cells. Blood 76(3):570–577CrossRef
34.
go back to reference Politaki E, Agelaki S, Apostolaki S, Hatzidaki D, Strati A, Koinis F, Perraki M, Saloustrou G, Stoupis G, Kallergi G, Spiliotaki M, Skaltsi T, Lianidou E, Georgoulias V, Mavroudis D (2017) A comparison of three methods for the detection of circulating tumor cells in patients with early and metastatic breast cancer. Cell Physiol Biochem 44(2):594–606CrossRef Politaki E, Agelaki S, Apostolaki S, Hatzidaki D, Strati A, Koinis F, Perraki M, Saloustrou G, Stoupis G, Kallergi G, Spiliotaki M, Skaltsi T, Lianidou E, Georgoulias V, Mavroudis D (2017) A comparison of three methods for the detection of circulating tumor cells in patients with early and metastatic breast cancer. Cell Physiol Biochem 44(2):594–606CrossRef
35.
go back to reference Sun C, Chen X, Xu J, Wei M, Wang J, Mi X, Wang X, Wu Y, Liu Y (2013) Fabrication of an inorganic–organic hybrid based on an iron-substituted polyoxotungstate as a peroxidase for colorimetric immunoassays of H2O2 and cancer cells. J Mater Chem A 1(15):4699–4705. https://doi.org/10.1039/C3TA01255GCrossRef Sun C, Chen X, Xu J, Wei M, Wang J, Mi X, Wang X, Wu Y, Liu Y (2013) Fabrication of an inorganic–organic hybrid based on an iron-substituted polyoxotungstate as a peroxidase for colorimetric immunoassays of H2O2 and cancer cells. J Mater Chem A 1(15):4699–4705. https://​doi.​org/​10.​1039/​C3TA01255GCrossRef
41.
go back to reference Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, Ryan P, Balis UJ, Tompkins RG, Haber DA, Toner M (2007) Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450(7173):1235–1239CrossRef Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, Ryan P, Balis UJ, Tompkins RG, Haber DA, Toner M (2007) Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450(7173):1235–1239CrossRef
42.
go back to reference Shi SR, Liu C, Pootrakul L, Tang L, Young A, Chen R, Cote RJ, Taylor CR (2008) Evaluation of the value of frozen tissue section used as “gold standard” for immunohistochemistry. Am J Clin Pathol 129(3):358–366CrossRef Shi SR, Liu C, Pootrakul L, Tang L, Young A, Chen R, Cote RJ, Taylor CR (2008) Evaluation of the value of frozen tissue section used as “gold standard” for immunohistochemistry. Am J Clin Pathol 129(3):358–366CrossRef
43.
go back to reference Taylor CR (2006) Standardization in immunohistochemistry: the role of antigen retrieval in molecular morphology. Biotech Histochem 81(1):3–12CrossRef Taylor CR (2006) Standardization in immunohistochemistry: the role of antigen retrieval in molecular morphology. Biotech Histochem 81(1):3–12CrossRef
44.
go back to reference O’Leary TJ (2001) Standardization in immunohistochemistry. Appl Immunohisto M M 9(1):3–8CrossRef O’Leary TJ (2001) Standardization in immunohistochemistry. Appl Immunohisto M M 9(1):3–8CrossRef
48.
go back to reference Fan K, Zhou M, Yan X (2014) Novel properties and applications of human ferritin expressed by Escherichia coli. Microbiol China 41(3):520–538 Fan K, Zhou M, Yan X (2014) Novel properties and applications of human ferritin expressed by Escherichia coli. Microbiol China 41(3):520–538
49.
go back to reference Fan KL, Gao LZ, Yan XY (2013) Human ferritin for tumor detection and therapy. Wires Nanomed Nanobi 5(4):287–298CrossRef Fan KL, Gao LZ, Yan XY (2013) Human ferritin for tumor detection and therapy. Wires Nanomed Nanobi 5(4):287–298CrossRef
50.
go back to reference Cai Y, Cao CQ, He XQ, Yang CY, Tian LX, Zhu RX, Pan YX (2015) Enhanced magnetic resonance imaging and staining of cancer cells using ferrimagnetic H-ferritin nanoparticles with increasing core size. Int J Nanomed 10:2619–2634. https://doi.org/10.2147/ijn.s80025 Cai Y, Cao CQ, He XQ, Yang CY, Tian LX, Zhu RX, Pan YX (2015) Enhanced magnetic resonance imaging and staining of cancer cells using ferrimagnetic H-ferritin nanoparticles with increasing core size. Int J Nanomed 10:2619–2634. https://​doi.​org/​10.​2147/​ijn.​s80025
54.
go back to reference Ragg R, Schilmann AM, Korschelt K, Wieseotte C, Kluenker M, Viel M, Volker L, Preiss S, Herzberger J, Frey H, Heinze K, Blumler P, Tahir MN, Natalio F, Tremel W (2016) Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast. J Mater Chem B 4(46):7423–7428. https://doi.org/10.1039/c6tb02078jCrossRef Ragg R, Schilmann AM, Korschelt K, Wieseotte C, Kluenker M, Viel M, Volker L, Preiss S, Herzberger J, Frey H, Heinze K, Blumler P, Tahir MN, Natalio F, Tremel W (2016) Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast. J Mater Chem B 4(46):7423–7428. https://​doi.​org/​10.​1039/​c6tb02078jCrossRef
61.
go back to reference Wang ZZ, Zhang Y, Ju EG, Liu Z, Cao FF, Chen ZW, Ren JS, Qu XG (2018) Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors. Nat Commun 9 Wang ZZ, Zhang Y, Ju EG, Liu Z, Cao FF, Chen ZW, Ren JS, Qu XG (2018) Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors. Nat Commun 9
62.
63.
go back to reference Wason MS, Colon J, Das S, Seal S, Turkson J, Zhao JH, Baker CH (2013) Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production. Nanomed-Nanotechnol 9(4):558–569CrossRef Wason MS, Colon J, Das S, Seal S, Turkson J, Zhao JH, Baker CH (2013) Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production. Nanomed-Nanotechnol 9(4):558–569CrossRef
64.
go back to reference Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J (2011) Photodynamic therapy of cancer: an update. CA Cancer J Clin 61(4):250–281. https://doi.org/10.3322/caac.20114CrossRef Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J (2011) Photodynamic therapy of cancer: an update. CA Cancer J Clin 61(4):250–281. https://​doi.​org/​10.​3322/​caac.​20114CrossRef
70.
go back to reference Chen HJ, Zhou XB, Gao Y, Zheng BY, Tang FX, Huang JD (2014) Recent progress in development of new sonosensitizers for sonodynamic cancer therapy. Drug Discov Today 19(4):502–509CrossRef Chen HJ, Zhou XB, Gao Y, Zheng BY, Tang FX, Huang JD (2014) Recent progress in development of new sonosensitizers for sonodynamic cancer therapy. Drug Discov Today 19(4):502–509CrossRef
76.
go back to reference Zhang C, Ni DL, Liu YY, Yao HL, Bu WB, Shi JL (2017) Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy. Nat Nanotechnol 12(4):378–386CrossRef Zhang C, Ni DL, Liu YY, Yao HL, Bu WB, Shi JL (2017) Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy. Nat Nanotechnol 12(4):378–386CrossRef
77.
go back to reference Marx J (2003) A boost for tumor starvation (vol 301, pg 452, 2003). Science 302(5649):1333–1333CrossRef Marx J (2003) A boost for tumor starvation (vol 301, pg 452, 2003). Science 302(5649):1333–1333CrossRef
78.
go back to reference Galluzzi L, Bravo-San Pedro JM, Demaria S, Formenti SC, Kroemer G (2017) Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nat Rev Clin Oncol 14(4):247–258CrossRef Galluzzi L, Bravo-San Pedro JM, Demaria S, Formenti SC, Kroemer G (2017) Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nat Rev Clin Oncol 14(4):247–258CrossRef
79.
go back to reference Asati A, Santra S, Kaittanis C, Nath S, Perez JM (2009) Oxidase-like activity of polymer-coated cerium oxide nanoparticles. Angew Chem Int Edit 48(13):2308–2312CrossRef Asati A, Santra S, Kaittanis C, Nath S, Perez JM (2009) Oxidase-like activity of polymer-coated cerium oxide nanoparticles. Angew Chem Int Edit 48(13):2308–2312CrossRef
80.
go back to reference Wan Y, Qi P, Zhang D, Wu JJ, Wang Y (2012) Manganese oxide nanowire-mediated enzyme-linked immunosorbent assay. Biosens Bioelectron 33(1):69–74CrossRef Wan Y, Qi P, Zhang D, Wu JJ, Wang Y (2012) Manganese oxide nanowire-mediated enzyme-linked immunosorbent assay. Biosens Bioelectron 33(1):69–74CrossRef
81.
go back to reference Liu JB, Hu XN, Hou S, Wen T, Liu WQ, Zhu X, Yin JJ, Wu XC (2012) Au@Pt core/shell nanorods with peroxidase- and ascorbate oxidase-like activities for improved detection of glucose. Sens Actuat B Chem 166:708–714CrossRef Liu JB, Hu XN, Hou S, Wen T, Liu WQ, Zhu X, Yin JJ, Wu XC (2012) Au@Pt core/shell nanorods with peroxidase- and ascorbate oxidase-like activities for improved detection of glucose. Sens Actuat B Chem 166:708–714CrossRef
82.
go back to reference Kong L, Cai X, Zhou XH, Wong LL, Karakoti AS, Seal S, McGinnis JF (2011) Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways. Neurobiol Dis 42(3):514–523CrossRef Kong L, Cai X, Zhou XH, Wong LL, Karakoti AS, Seal S, McGinnis JF (2011) Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways. Neurobiol Dis 42(3):514–523CrossRef
83.
go back to reference Singh S, Dosani T, Karakoti AS, Kumar A, Seal S, Self WT (2011) A phosphate-dependent shift in redox state of cerium oxide nanoparticles and its effects on catalytic properties. Biomaterials 32(28):6745–6753CrossRef Singh S, Dosani T, Karakoti AS, Kumar A, Seal S, Self WT (2011) A phosphate-dependent shift in redox state of cerium oxide nanoparticles and its effects on catalytic properties. Biomaterials 32(28):6745–6753CrossRef
84.
go back to reference Lee YM, Garcia MA, Huls NAF, Sun SH (2010) Synthetic tuning of the catalytic properties of Au-Fe3O4 Nanoparticles. Angew Chem Int Edit 49(7):1271–1274CrossRef Lee YM, Garcia MA, Huls NAF, Sun SH (2010) Synthetic tuning of the catalytic properties of Au-Fe3O4 Nanoparticles. Angew Chem Int Edit 49(7):1271–1274CrossRef
85.
go back to reference Chen HW, Wang LY, Yeh J, Wu XY, Cao ZH, Wang YA, Zhang MM, Yang L, Mao H (2010) Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-P gamma MPS copolymer coating. Biomaterials 31(20):5397–5407CrossRef Chen HW, Wang LY, Yeh J, Wu XY, Cao ZH, Wang YA, Zhang MM, Yang L, Mao H (2010) Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-P gamma MPS copolymer coating. Biomaterials 31(20):5397–5407CrossRef
87.
go back to reference Grubbs RB (2007) Roles of polymer ligands in nanoparticle stabilization. Polym Rev 47(2):197–215CrossRef Grubbs RB (2007) Roles of polymer ligands in nanoparticle stabilization. Polym Rev 47(2):197–215CrossRef
88.
go back to reference Doshi N, Mitragotri S (2009) Designer biomaterials for nanomedicine. Adv Funct Mater 19(24):3843–3854CrossRef Doshi N, Mitragotri S (2009) Designer biomaterials for nanomedicine. Adv Funct Mater 19(24):3843–3854CrossRef
Metadata
Title
Nanozyme-Based Tumor Theranostics
Authors
Xiangqin Meng
Lizeng Gao
Kelong Fan
Xiyun Yan
Copyright Year
2020
Publisher
Springer Singapore
DOI
https://doi.org/10.1007/978-981-15-1490-6_13

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