Introduction
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Process The search of sustainability involves necessarily the improvement or optimization of existing processes. Thus, the process intensification increases the process efficiency by reducing equipment size. It has significant benefits in terms of environment. The physicochemical activation such as ultrasound, microwaves, mechanochemistry aims also to reduce energy costs.
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Catalysis It also contributes to process improvement, beyond the expected progress in heterogeneous catalysis using precious metals; the use of white biotechnologies for the manufacture, processing or degradation of molecules presents a significant potential to improve reaction yields.
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Restorative chemistry The fight against pollution through the implementation of techniques reducing air pollution emissions, to process wastes, wastewater and soil. Biotechnology and photocatalysis are interesting methods used to reduce gas emissions and show the importance of a multidisciplinary approach.
Energy, environment and molecular chemistry
New activation methods used in green chemistry for the synthesis of high added value molecules
Methods
Materials and equipment
Physical measurements
Amidation reaction procedure
Suzuki–Miyaura reaction procedure
Reduction of nitrobenzenes procedure
Biotransformation screening procedure
Enantioselective α-alkylation procedure
Results and discussion
Microwaves assisted solvent—free amidation
Amine (2 mmol) | 2 W, 90 °C, 1 h | 10 W, 130 °C, 1 h | ||
---|---|---|---|---|
Starting amine | Monoacetylated product | Starting amine | Monoacetylated product | |
31 | 69 | 0 | 100 | |
42 | 44 | 7 | 73 | |
93 | 7 | 4 | 94a |
Suzuki–Miyaura cross-coupling assisted by microwaves
Aryl halide (15) | Boronic acid pinacol ester (16) | Heating conditions | Microwave conditions 15 min | ||
---|---|---|---|---|---|
Time (h) | Yielda (%) | Power, Δ | Yielda (%) | ||
15a (OH) | 1.5 | 94 | 10 W, 60 °C | 93 | |
15a
| 1.5 | 95 | 10 W, 60 °C | 92 | |
15a
| 1.5 | 70 | 10 W, 60 °C | 87 | |
15a
| 1.5 | 98 | 10 W, 60 °C | 85 | |
15b (OMe) | 3 | 97 | 50 W, 60 °C | 98 | |
15b
| 6 | 98 | 50 W, 150 °C | 68 | |
15b
| 1.5 | 78 | 50 W, 60 °C | 96 | |
15c (Me) | 1.5 | 99 | 50 W, 80 °C | 84 |