Advertisement
Published in:
2015 | OriginalPaper | Chapter
Novel Fabrication and Operation of Microfluidic Platforms for On-Chip Single Cell Isolation and Bioanalysis
Authors : Ainara Benavente-Babace, Sergio Arana, Derek J. Hansford, Eva Pérez-Lorenzo, Maite Mujika
Published in: 6th European Conference of the International Federation for Medical and Biological Engineering
Publisher: Springer International Publishing
Activate our intelligent search to find suitable subject content or patents.
Select sections of text to find matching patents with Artificial Intelligence. powered by
Select sections of text to find additional relevant content using AI-assisted search. powered by
Different multipurpose platforms were designed, fabricated and characterized to enable key analyses of cell behavior and function at single cell level namely cell-cell interactions or cell migration under controlled conditions. The developed designs offer several advantages over previous approaches including high throughput, simplicity in experimental setup and control, and potential for coupling it to different substrates. Key parameters for optimum fabrication, efficient cell capture and seeding with high viability were established. Further, important factors for long-term experiments were defined. Cleanness and versatility of this microfluidic device makes it a potential tool of high interest in cell-based drug testing, cancer research or cell therapy.