Prevention of healthcare related infections requires appropriate hand hygiene before and after procedures. Hand hygiene is one of the main Patient Safety Practices. Compliance and upholding have to be supported by a correct behavioral, organizational and structural approach. A Team expert in Human Factors and Ergonomics (ERGOMeyer) has developed an implementation and support service that collects the contributions of cognitive psychology and the theory of nudging, through point of care and thoughtful communication. An increase in adherence to hand hygiene up to 92.2% in 2021, an increased use of alcoholic gel, both certainly also related to the precautions implemented to cope with the SAR-CoV-2 pandemic, and infection rates close to the standard values were observed. It also ensured an appropriate management of critical issues due to the pandemic. By planning a good architecture of choices, it is possible to act on the behavior of operators and users, encouraging the correct actions and increasing patient safety.