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Published in:
2021 | OriginalPaper | Chapter
Numerical Analysis of Laser-Assisted Cryopreservation of Biological Tissues
Authors : Saurabh Das, Satya Prakash Kar
Published in: Proceedings of International Conference on Thermofluids
Publisher: Springer Singapore
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Abstract
Cryopreservation of tissue is an important aspect of bioengineering, and it does not involve any ice formation, rather tissue is solidified by intense increase in viscosity. This can only be brought by applying cooling rates in the order of 105 K/min. An external heating source followed by a sudden cooling is suggested here. The heat source in this study is assumed to be a Gaussian laser, and the cryogen used to cool down the tissue would be liquid nitrogen. This numerical study tries to understand the viability and feasibility of laser-assisted cryopreservation technique while accounting for convective–radiative heat loss and following a dual phase lag conduction equation. The algebraic equations obtained after discretization of the governing equations by finite volume method (FVM) are then solved by the tri-diagonal matrix method. Enthalpy-porosity technique is used to capture the frozen tissues. Cooling rates at various locations are calculated, and the feasibility of this approach is tested.