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Mathematical and Physical Modeling Principles of Complex Biological Systems Read chapter Read first chapter

2019 | OriginalPaper | Chapter

Pathological Consequences of Reduced Cerebrospinal Fluid Pressure: Experimental Studies

Authors : Zheng Zhang, Jing Li, Xiaoxia Li, Ningli Wang

Published in: Ocular Fluid Dynamics

Publisher: Springer International Publishing

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Abstract

It has been speculated that a low orbital cerebrospinal fluid pressure (CSFP) may perhaps play a role in the pathogenesis of glaucomatous optic neuropathy. To verify the hypothesis, we conducted a serial of experimental study on low-CSFP models of monkeys and rats. Our studies showed that a reduction in CSFP could result in the structural and physiological changes of optic nerve and some molecular biology reactions in the optic axons. We hope that our chapter will be helpful for the further research in the pathogenesis of glaucoma.

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previous chapter Anatomy and Physiology of the Cerebrospinal Fluid
next chapter Instruments to Measure and Visualize Geometrical and Functional Parameters Related to the Fluid Dynamics of Cerebrospinal Fluid in the Eye
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Metadata
Title
Pathological Consequences of Reduced Cerebrospinal Fluid Pressure: Experimental Studies
Authors
Zheng Zhang
Jing Li
Xiaoxia Li
Ningli Wang
Copyright Year
2019
Book
Ocular Fluid Dynamics

Print ISBN: 978-3-030-25885-6

Electronic ISBN: 978-3-030-25886-3

Copyright Year: 2019

DOI
https://doi.org/10.1007/978-3-030-25886-3_19

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