Skip to main content
Top
Published in: Sexuality Research and Social Policy 1/2021

21-02-2020

Perspectives on and Preferences for On-Demand and Long-Acting PrEP Among Sexual and Gender Minority Adolescents Assigned Male at Birth

Authors: Kathryn Macapagal, Mara Nery-Hurwit, Margaret Matson, Shariell Crosby, George J. Greene

Published in: Sexuality Research and Social Policy | Issue 1/2021

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Introduction

Sexual and gender minority (SGM) adolescents assigned male at birth who have sex with male partners are at increased risk for HIV. Daily oral pre-exposure prophylaxis (PrEP) is available for minor adolescents in the United States, who may have difficulty with adherence. Adolescents’ perspectives toward emerging PrEP delivery methods that would not require daily pill-taking have not been well-explored.

Methods

We conducted online surveys and focus groups in November 2018–February 2019 with 59 SGM adolescents assigned male at birth who reported sex with or attraction to male partners. Questions assessed their perspectives on and preferences for biomedical (on-demand, injection, implant) and non-biomedical HIV prevention options (condoms). Data were analyzed thematically.

Results

Of all prevention options, the implant and condoms were rated highest, and participants preferred the implant over other biomedical options. Convenience, duration, and ease of access played important roles in adolescents’ preferences. Parents were viewed as a barrier to taking PrEP regardless of delivery method due to their role in adolescents’ ability to access healthcare.

Conclusions

SGM adolescents are interested in long-acting PrEP, yet also perceive substantial obstacles to using biomedical prevention that reflect adolescents’ developmental contexts.

Policy Implications

State laws expanding adolescents’ access to HIV preventive services, sex education inclusive of PrEP information, and parent- and provider-initiated PrEP conversations can reduce barriers regardless of PrEP delivery method. Research to accelerate the availability of long-acting implants for adolescents is needed.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Footnotes
1
Although 18-year olds are legal adults in the U.S., those who were in high school or middle school were eligible to participate, as we anticipated that perspectives toward the different PrEP modalities may be similar for youth in secondary school and likely living with their parents regardless of whether they were minors or not.
 
Literature
go back to reference Awad, G. H., Sagrestano, L. M., Kittleson, M. J., & Sarvela, P. D. (2004). Development of a measure of barriers to HIV testing among individuals at high risk. AIDS Education and Prevention, 16, 115–125.CrossRef Awad, G. H., Sagrestano, L. M., Kittleson, M. J., & Sarvela, P. D. (2004). Development of a measure of barriers to HIV testing among individuals at high risk. AIDS Education and Prevention, 16, 115–125.CrossRef
go back to reference Bauermeister, J. A., Meanley, S., Pingel, E., Soler, J. H., & Harper, G. W. (2013). PrEP awareness and perceived barriers among single young men who have sex with men. Current HIV Research, 11, 520–527. Bauermeister, J. A., Meanley, S., Pingel, E., Soler, J. H., & Harper, G. W. (2013). PrEP awareness and perceived barriers among single young men who have sex with men. Current HIV Research, 11, 520–527.
go back to reference Biello, K. B., Hosek, S., Drucker, M. T., Belzer, M., Mimiaga, M. J., Marrow, E., Coffey-Esquivel, J., Brothers, J., & Mayer, K. H. (2018). Preferences for injectable PrEP among young U.S. Cisgender men and transgender women and men who have sex with men. Archives of Sexual Behavior, 47, 2101–2107. https://doi.org/10.1007/s10508-017-1049-7. Biello, K. B., Hosek, S., Drucker, M. T., Belzer, M., Mimiaga, M. J., Marrow, E., Coffey-Esquivel, J., Brothers, J., & Mayer, K. H. (2018). Preferences for injectable PrEP among young U.S. Cisgender men and transgender women and men who have sex with men. Archives of Sexual Behavior, 47, 2101–2107. https://​doi.​org/​10.​1007/​s10508-017-1049-7.
go back to reference Boonstra, H. D. (2015). Meeting the sexual and reproductive health needs of adolescents in school-based health centers. Guttmacher Policy Review, 18, 21–26. Boonstra, H. D. (2015). Meeting the sexual and reproductive health needs of adolescents in school-based health centers. Guttmacher Policy Review, 18, 21–26.
go back to reference Calder, B. J., Schieffer, R. J., Bryndza Tfaily, E., D'Aquila, R., Greene, G. J., Carballo-Dieguez, A., et al. (2018). Qualitative consumer research on acceptance of long-acting pre-exposure prophylaxis products among men having sex with men and medical practitioners in the United States. AIDS Research and Human Retroviruses, 34, 849–856. https://doi.org/10.1089/AID.2018.0214. Calder, B. J., Schieffer, R. J., Bryndza Tfaily, E., D'Aquila, R., Greene, G. J., Carballo-Dieguez, A., et al. (2018). Qualitative consumer research on acceptance of long-acting pre-exposure prophylaxis products among men having sex with men and medical practitioners in the United States. AIDS Research and Human Retroviruses, 34, 849–856. https://​doi.​org/​10.​1089/​AID.​2018.​0214.
go back to reference Dedoose. (2019). Web application for managing, analyzing, and presenting qualitative and mixed method data. Los Angeles, CA: SocioCultural Research Consultants, LLC Retrieved from https://www.dedoose.com/. Dedoose. (2019). Web application for managing, analyzing, and presenting qualitative and mixed method data. Los Angeles, CA: SocioCultural Research Consultants, LLC Retrieved from https://​www.​dedoose.​com/​.
go back to reference Fisher, C. B., Fried, A. L., Desmond, M., Macapagal, K., & Mustanski, B. (2017). Facilitators and barriers to participation in PrEP HIV prevention trials involving transgender male and female adolescents and emerging adults. AIDS Education and Prevention, 29, 205–217. https://doi.org/10.1521/aeap.2017.29.3.205. Fisher, C. B., Fried, A. L., Desmond, M., Macapagal, K., & Mustanski, B. (2017). Facilitators and barriers to participation in PrEP HIV prevention trials involving transgender male and female adolescents and emerging adults. AIDS Education and Prevention, 29, 205–217. https://​doi.​org/​10.​1521/​aeap.​2017.​29.​3.​205.
go back to reference Fisher, C. B., Fried, A. L., Ibrahim Puri, L., Macapagal, K., & Mustanski, B. (2018). "Free testing and PrEP without outing myself to parents:" Motivation to participate in oral and injectable PrEP clinical trials among adolescent men who have sex with men. PLoS One, 13, e0200560. https://doi.org/10.1371/journal.pone.0200560. Fisher, C. B., Fried, A. L., Ibrahim Puri, L., Macapagal, K., & Mustanski, B. (2018). "Free testing and PrEP without outing myself to parents:" Motivation to participate in oral and injectable PrEP clinical trials among adolescent men who have sex with men. PLoS One, 13, e0200560. https://​doi.​org/​10.​1371/​journal.​pone.​0200560.
go back to reference Gill, K., Pidwell, T., Dietrich, J., Gray, G., Bennie, T., Kayamba, F., . . . Bekker, L. G. (2017). A demonstration open label study to assess the acceptability, safety, and use of Truvada pre-exposure prophylaxis in healthy, HIV-uninfected adolescents, 15–19 years of age. Paper presented at the International AIDS Society Conference on HIV Science, Paris, France. Gill, K., Pidwell, T., Dietrich, J., Gray, G., Bennie, T., Kayamba, F., . . . Bekker, L. G. (2017). A demonstration open label study to assess the acceptability, safety, and use of Truvada pre-exposure prophylaxis in healthy, HIV-uninfected adolescents, 15–19 years of age. Paper presented at the International AIDS Society Conference on HIV Science, Paris, France.
go back to reference Greene, G. J., Swann, G., Fought, A. J., Carballo-Dieguez, A., Hope, T. J., Kiser, P. F., et al. (2017). Preferences for long-acting pre-exposure prophylaxis (PrEP), daily oral PrEP, or condoms for HIV prevention among U.S. men who have sex with men. AIDS & Behavior, 21, 1336–1349. https://doi.org/10.1007/s10461-016-1565-9. Greene, G. J., Swann, G., Fought, A. J., Carballo-Dieguez, A., Hope, T. J., Kiser, P. F., et al. (2017). Preferences for long-acting pre-exposure prophylaxis (PrEP), daily oral PrEP, or condoms for HIV prevention among U.S. men who have sex with men. AIDS & Behavior, 21, 1336–1349. https://​doi.​org/​10.​1007/​s10461-016-1565-9.
go back to reference HIV Prevention Trials Network. (2018). A phase 2b/3 double blind safety and efficacy study of injectable cabotegravir compared to daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC), for pre-exposure prophylaxis in HIV-uninfected cisgender men and transgender women who have sex with men. Retrieved from https://www.hptn.org/research/studies/hptn083. HIV Prevention Trials Network. (2018). A phase 2b/3 double blind safety and efficacy study of injectable cabotegravir compared to daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC), for pre-exposure prophylaxis in HIV-uninfected cisgender men and transgender women who have sex with men. Retrieved from https://​www.​hptn.​org/​research/​studies/​hptn083.
go back to reference Hope, T., & Kiser, P. F. (2015-2020). Sustained long acting prevention against HIV. Northwestern University at Chicago: National Institute on Allergy and Infectious Diseases, 1UM1AI120184-01. Hope, T., & Kiser, P. F. (2015-2020). Sustained long acting prevention against HIV. Northwestern University at Chicago: National Institute on Allergy and Infectious Diseases, 1UM1AI120184-01.
go back to reference Hosek, S., Celum, C., Wilson, C. M., Kapogiannis, B., Delany-Moretlwe, S., & Bekker, L. G. (2016). Preventing HIV among adolescents with oral PrEP: Observations and challenges in the United States and South Africa. Journal of the International AIDS Society, 19, 21107. https://doi.org/10.7448/IAS.19.7.21107. Hosek, S., Celum, C., Wilson, C. M., Kapogiannis, B., Delany-Moretlwe, S., & Bekker, L. G. (2016). Preventing HIV among adolescents with oral PrEP: Observations and challenges in the United States and South Africa. Journal of the International AIDS Society, 19, 21107. https://​doi.​org/​10.​7448/​IAS.​19.​7.​21107.
go back to reference Hosek, S. G., Landovitz, R. J., Kapogiannis, B., Siberry, G. K., Rudy, B., Rutledge, B., Liu, N., Harris, D. R., Mulligan, K., Zimet, G., Mayer, K. H., Anderson, P., Kiser, J. J., Lally, M., Brothers, J., Bojan, K., Rooney, J., & Wilson, C. M. (2017). Safety and feasibility of antiretroviral preexposure prophylaxis for adolescent men who have sex with men aged 15 to 17 years in the United States. JAMA Pediatrics, 171, 1063–1071. https://doi.org/10.1001/jamapediatrics.2017.2007.CrossRefPubMedPubMedCentral Hosek, S. G., Landovitz, R. J., Kapogiannis, B., Siberry, G. K., Rudy, B., Rutledge, B., Liu, N., Harris, D. R., Mulligan, K., Zimet, G., Mayer, K. H., Anderson, P., Kiser, J. J., Lally, M., Brothers, J., Bojan, K., Rooney, J., & Wilson, C. M. (2017). Safety and feasibility of antiretroviral preexposure prophylaxis for adolescent men who have sex with men aged 15 to 17 years in the United States. JAMA Pediatrics, 171, 1063–1071. https://​doi.​org/​10.​1001/​jamapediatrics.​2017.​2007.CrossRefPubMedPubMedCentral
go back to reference Magnuson, D., Hawkins, T., & Mera, R. (2018). Adolescent use of Truvada (FTC/TDF) for HIV pre-exposure prophylaxis (PrEP) in the United States: 2012-2017. Paper presented at the International AIDS Society, Amsterdam. Magnuson, D., Hawkins, T., & Mera, R. (2018). Adolescent use of Truvada (FTC/TDF) for HIV pre-exposure prophylaxis (PrEP) in the United States: 2012-2017. Paper presented at the International AIDS Society, Amsterdam.
go back to reference Matthews, R. P., Barrett, S. E., Patel, M., Zhu, W., Fillgrove, K. L., Haspeslagh, L., . . . Iwamoto, M. (2019). First-in-human trial of MK-8591-eluting implants demonstrates concentrations suitable for HIV prophylaxis for at least one year. Paper presented at the 10th IAS conference on HIV science, Mexico City, Mexico. http://programme.ias2019.org/Abstract/Abstract/4843. Matthews, R. P., Barrett, S. E., Patel, M., Zhu, W., Fillgrove, K. L., Haspeslagh, L., . . . Iwamoto, M. (2019). First-in-human trial of MK-8591-eluting implants demonstrates concentrations suitable for HIV prophylaxis for at least one year. Paper presented at the 10th IAS conference on HIV science, Mexico City, Mexico. http://​programme.​ias2019.​org/​Abstract/​Abstract/​4843.
go back to reference Ouellet, E., Durand, M., Guertin, J. R., LeLorier, J., & Tremblay, C. L. (2015). Cost effectiveness of 'on demand' HIV pre-exposure prophylaxis for non-injection drug-using men who have sex with men in Canada. Canadian Journal of Infectious Diseases and Medical Microbiology, 26, 23–29.CrossRef Ouellet, E., Durand, M., Guertin, J. R., LeLorier, J., & Tremblay, C. L. (2015). Cost effectiveness of 'on demand' HIV pre-exposure prophylaxis for non-injection drug-using men who have sex with men in Canada. Canadian Journal of Infectious Diseases and Medical Microbiology, 26, 23–29.CrossRef
go back to reference Parsons, J. T., Rendina, H. J., Whitfield, T. H., & Grov, C. (2016). Familiarity with and preferences for oral and long-acting injectable HIV pre-exposure prophylaxis (PrEP) in a national sample of gay and bisexual men in the U.S. AIDS & Behavior, 20, 1390–1399. https://doi.org/10.1007/s10461-016-1370-5. Parsons, J. T., Rendina, H. J., Whitfield, T. H., & Grov, C. (2016). Familiarity with and preferences for oral and long-acting injectable HIV pre-exposure prophylaxis (PrEP) in a national sample of gay and bisexual men in the U.S. AIDS & Behavior, 20, 1390–1399. https://​doi.​org/​10.​1007/​s10461-016-1370-5.
go back to reference Rael, C. T., Martinez, M., Giguere, R., Bockting, W., MacCrate, C., Mellman, W., et al. (2019). Transgender women’s concerns and preferences on potential future long-acting biomedical HIV prevention strategies: The case of injections and implanted medication delivery devices (imdds). AIDS and Behavior. https://doi.org/10.1007/s10461-019-02703-5 Rael, C. T., Martinez, M., Giguere, R., Bockting, W., MacCrate, C., Mellman, W., et al. (2019). Transgender women’s concerns and preferences on potential future long-acting biomedical HIV prevention strategies: The case of injections and implanted medication delivery devices (imdds). AIDS and Behavior. https://​doi.​org/​10.​1007/​s10461-019-02703-5
go back to reference Reyniers, T., Nostlinger, C., Laga, M., De Baetselier, I., Crucitti, T., Wouters, K., et al. (2018). Choosing between daily and event-driven pre-exposure prophylaxis: Results of a belgian PrEP demonstration project. Journal of Acquired Immune Deficiency Syndromes, 79, 186–194. https://doi.org/10.1097/QAI.0000000000001791. Reyniers, T., Nostlinger, C., Laga, M., De Baetselier, I., Crucitti, T., Wouters, K., et al. (2018). Choosing between daily and event-driven pre-exposure prophylaxis: Results of a belgian PrEP demonstration project. Journal of Acquired Immune Deficiency Syndromes, 79, 186–194. https://​doi.​org/​10.​1097/​QAI.​0000000000001791​.
go back to reference SB-159 HIV: Preexposure and postexposure prophylaxis. (2019). SB-159, California State Legislature. SB-159 HIV: Preexposure and postexposure prophylaxis. (2019). SB-159, California State Legislature.
go back to reference Teitcher, J. E., Bockting, W. O., Bauermeister, J. A., Hoefer, C. J., Miner, M. H., & Klitzman, R. L. (2015). Detecting, preventing, and responding to "fraudsters" in internet research: Ethics and tradeoffs. The Journal of Law, Medicine & Ethics, 43, 116–133. https://doi.org/10.1111/jlme.12200.CrossRef Teitcher, J. E., Bockting, W. O., Bauermeister, J. A., Hoefer, C. J., Miner, M. H., & Klitzman, R. L. (2015). Detecting, preventing, and responding to "fraudsters" in internet research: Ethics and tradeoffs. The Journal of Law, Medicine & Ethics, 43, 116–133. https://​doi.​org/​10.​1111/​jlme.​12200.CrossRef
Metadata
Title
Perspectives on and Preferences for On-Demand and Long-Acting PrEP Among Sexual and Gender Minority Adolescents Assigned Male at Birth
Authors
Kathryn Macapagal
Mara Nery-Hurwit
Margaret Matson
Shariell Crosby
George J. Greene
Publication date
21-02-2020
Publisher
Springer US
Published in
Sexuality Research and Social Policy / Issue 1/2021
Print ISSN: 1868-9884
Electronic ISSN: 1553-6610
DOI
https://doi.org/10.1007/s13178-020-00441-1

Other articles of this Issue 1/2021

Sexuality Research and Social Policy 1/2021 Go to the issue