Skip to main content
Top

2013 | OriginalPaper | Chapter

Petri Net Modeling and Analysis Based on Gene Logic Network

Authors : Yulin Zhang, Shudong Wang, Hongyue Wu, Yan Yi

Published in: Proceedings of The Eighth International Conference on Bio-Inspired Computing: Theories and Applications (BIC-TA), 2013

Publisher: Springer Berlin Heidelberg

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Petri net has recently emerged as a promising tool for the modeling and analysis of molecular networks. In this research, gene logic network constructed by approach-logic analysis of phylogenetic profiles method is described. In order to depict the logic interactions between genes, a new Petri net formalism with augmented inhibitor arc is proposed, which is called ALTPN. Two different types of places and different transitions are formulated in ALTPN, and then corresponding firing rule is given. Further, ALTPN of all 1-order and 2-order gene logic types are listed. Finally reachability graph method is used to accomplish asynchronous dynamic analysis of gene logic interactions in colon cancer and some conclusions are drawn.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literature
1.
go back to reference Akutsu T, Miyano S, Kuhara S (1999) Identification of genetic networks from a small number of gene expression patterns under the Boolean network model. Pac Symp Biocomputing 4:17–28 Akutsu T, Miyano S, Kuhara S (1999) Identification of genetic networks from a small number of gene expression patterns under the Boolean network model. Pac Symp Biocomputing 4:17–28
2.
go back to reference Kauffman SA (1972) The large-scale structure and dynamics of gene control circuits: an ensemble approach. Theory Biol 44(1):167–190CrossRef Kauffman SA (1972) The large-scale structure and dynamics of gene control circuits: an ensemble approach. Theory Biol 44(1):167–190CrossRef
3.
go back to reference Marlovits G, Tyson CJ, Novak B, Tyson JJ (1998) Modeling M-phase control in Xenopus oocyte extracts: the surveillance mechanism for unreplicated DNA. Biophys Chem 72:169–184CrossRef Marlovits G, Tyson CJ, Novak B, Tyson JJ (1998) Modeling M-phase control in Xenopus oocyte extracts: the surveillance mechanism for unreplicated DNA. Biophys Chem 72:169–184CrossRef
4.
go back to reference Novak B, Csikasz-Nagy A, Gyory B, Chen K, Tyson JJ (1998) Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions. Biophys Chem 72:185–200CrossRef Novak B, Csikasz-Nagy A, Gyory B, Chen K, Tyson JJ (1998) Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions. Biophys Chem 72:185–200CrossRef
5.
go back to reference Friedman N, Linial M, Nachman I (2000) Using Bayesian networks to analyze expression data. J Comput Biol 7:601–620CrossRef Friedman N, Linial M, Nachman I (2000) Using Bayesian networks to analyze expression data. J Comput Biol 7:601–620CrossRef
6.
go back to reference Grzegorczyk M, Husmeier D, Rahnenfuhrer J (2011) Modeling non-stationary gene regulatory processes with the BGM model. Comput Stat 26(2):199–218CrossRefMATH Grzegorczyk M, Husmeier D, Rahnenfuhrer J (2011) Modeling non-stationary gene regulatory processes with the BGM model. Comput Stat 26(2):199–218CrossRefMATH
7.
go back to reference Chaouiya C (2007) Petri net modeling of biological networks. Briefings Bioinf 8(4):210–219CrossRef Chaouiya C (2007) Petri net modeling of biological networks. Briefings Bioinf 8(4):210–219CrossRef
8.
go back to reference Thomas R (1973) Boolean formalization of genetic control circuits. J Theor Biol 42(3):563–585CrossRef Thomas R (1973) Boolean formalization of genetic control circuits. J Theor Biol 42(3):563–585CrossRef
9.
go back to reference Bowers PM, Cokus SJ, Eisenberg D, Yeates TO (2004) Use of logic relationships to decipher protein network organization. Science 306(5706):2246–2249CrossRef Bowers PM, Cokus SJ, Eisenberg D, Yeates TO (2004) Use of logic relationships to decipher protein network organization. Science 306(5706):2246–2249CrossRef
10.
go back to reference Zhang J, Ji Y, Zhang L (2007) Extracting three-way gene interactions from microarray data. Bioinformatics 23(21):2903–2909CrossRef Zhang J, Ji Y, Zhang L (2007) Extracting three-way gene interactions from microarray data. Bioinformatics 23(21):2903–2909CrossRef
11.
go back to reference Wang S, Chen Y, Wang Q, Li E, Su Y, Meng D (2010) Analysis for gene networks based on logic relationships. J Syst Sci Complexity 23(5):435–447MathSciNetCrossRefMATH Wang S, Chen Y, Wang Q, Li E, Su Y, Meng D (2010) Analysis for gene networks based on logic relationships. J Syst Sci Complexity 23(5):435–447MathSciNetCrossRefMATH
12.
go back to reference Chaouiya C, Remy E, Ruet P, Thieffry D (2004) Qualitative modelling of genetic networks: from logical regulatory graphs to standard petri nets. Lect Notes Comp Sci 3099:137–156MathSciNetCrossRefMATH Chaouiya C, Remy E, Ruet P, Thieffry D (2004) Qualitative modelling of genetic networks: from logical regulatory graphs to standard petri nets. Lect Notes Comp Sci 3099:137–156MathSciNetCrossRefMATH
13.
go back to reference Comet J, Klaudel H, Liauzu S (2005) Modeling multi-valued genetic regulatory networks using high-level petri nets. Lect Notes Comp Sci 3536:208–227MathSciNetCrossRefMATH Comet J, Klaudel H, Liauzu S (2005) Modeling multi-valued genetic regulatory networks using high-level petri nets. Lect Notes Comp Sci 3536:208–227MathSciNetCrossRefMATH
14.
go back to reference Hardy S, Pierre NR (2004) Modeling and simulation of molecular biology systems using petri nets: modeling goals of various approaches. J Bioinf Comput Biol 2(4):619–637CrossRef Hardy S, Pierre NR (2004) Modeling and simulation of molecular biology systems using petri nets: modeling goals of various approaches. J Bioinf Comput Biol 2(4):619–637CrossRef
15.
go back to reference Matsuno H, Doi A, Nagasaki M (2000) Hybrid petri net representation of gene regulatory network. Pac Symp Biocomputing 5:338–349 Matsuno H, Doi A, Nagasaki M (2000) Hybrid petri net representation of gene regulatory network. Pac Symp Biocomputing 5:338–349
16.
go back to reference Simao E, Remy E, Thieffry E, Chaouiya C (2005) Qualitative modeling of regulated metabolic pathways: application to the tryptophan biosynthesis in E. coli. Bioinformatics 21(2):190–196 Simao E, Remy E, Thieffry E, Chaouiya C (2005) Qualitative modeling of regulated metabolic pathways: application to the tryptophan biosynthesis in E. coli. Bioinformatics 21(2):190–196
17.
go back to reference Ruan X, Wang J, Li H (2007) The establishment and application of a logical network model based on gene expression profiles of genes. Prog Biochem Biophys 34(8):871–880 Ruan X, Wang J, Li H (2007) The establishment and application of a logical network model based on gene expression profiles of genes. Prog Biochem Biophys 34(8):871–880
Metadata
Title
Petri Net Modeling and Analysis Based on Gene Logic Network
Authors
Yulin Zhang
Shudong Wang
Hongyue Wu
Yan Yi
Copyright Year
2013
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-37502-6_46

Premium Partner