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Cellulose
Published in: Cellulose 6/2021

23-02-2021 | Original Research

pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials

Authors: Trong Bien Tran, Tuan Hiep Tran, Yen Hai Vu, Thien Giap Le, Thao Thi Do, Nga Thi Nguyen, Thuan Thi Nguyen, Tung Bao Pham, Trung Quang Ngo, Quang Anh Luong, Chien Ngoc Nguyen

Published in: Cellulose | Issue 6/2021

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Abstract

Ethyl cellulose (EC) is widely used in the pharmaceutical field as a polymeric excipient to fabricate sustained-release drug delivery systems. To develop a controlled release carrier exploiting the unique characteristic acidic environment of the target tumor site, this study examined the use of EC and lecithin (LC) as a nanoparticulated system. Paclitaxel and dihydroartemisinin were used as model drug combinations. The optimized formulated nanoparticles (NPs) of EC (EC NPs) and EC/LC (EC/LC NPs) were spherical and approximately 130 nm in diameter as determined by dynamic light scattering and electron microscopy analyses. The in vitro drug release from EC/LC NPs exhibited a pH-dependent pattern. In in vitro cell studies, the NPs were taken up by cells, and cell growth was inhibited by drugs released from the formulations. Most importantly, the in vivo anti-tumor study in mice showed a significant reduction in tumor volume after the intravenous administration of EC/LC NPs, suggesting the potential of using EC and LC as controlled and pH-sensitive drug delivery carriers.
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Metadata
Title
pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
Authors
Trong Bien Tran
Tuan Hiep Tran
Yen Hai Vu
Thien Giap Le
Thao Thi Do
Nga Thi Nguyen
Thuan Thi Nguyen
Tung Bao Pham
Trung Quang Ngo
Quang Anh Luong
Chien Ngoc Nguyen
Publication date
23-02-2021
Publisher
Springer Netherlands
Published in
Cellulose / Issue 6/2021
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI
https://doi.org/10.1007/s10570-021-03769-y

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