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Published in:
Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography Read chapter Read first chapter

2020 | OriginalPaper | Chapter

PhenoFluor Deoxofluorination

Authors : Shuo Guo, Pingping Tang

Published in: Fluorination

Publisher: Springer Singapore

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Excerpt

The PhenoFluor, N,N′-,3-Bis(2,6-diisopropylphenyl)-2,2-difluoroimidazolidene, is a practical, commercially available, and thermally stable reagent for deoxyfluorination of a range of phenols and alcohols [1]. Most notably, the general method for nucleophilic deoxyfluorination has been accomplished for various complex natural products and pharmaceuticals. In addition, there are two modifications of the PhenoFluor: PhenoFluorMix and AlkylFluor. The following details (section “PhenoFluorMix-Mediated and AlkylFluor-Mediated Deoxyfluorination”) will describe their characters, respectively. Most research of PhenoFluor and related works were reported by Ritter’s Group. …

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previous chapter Perfluorination with F2
next chapter Selectfluor and Its Analogs’ Electrophilic Fluorination for Preparing Alkyl Fluorides
Literature
1.
2.
Fujimoto T, Becker F, Ritter T (2014) PhenoFluor: Practical Synthesis, New Formulation, and Deoxyfluorination of Heteroaromatics. Org Process Res Dev 18: 1041–1044PubMedPubMedCentral
3.
Sladojevich F, Arlow SI, Tang P, Ritter T (2013) Late-stage deoxyfluorination of alcohols with PhenoFluor. J Am Chem Soc 135: 2470–2473PubMedPubMedCentral
4.
Fujimoto T, Ritter T (2015) PhenoFluorMix: practical chemoselective deoxyfluorination of phenols. Organic lett 17: 544–547
5.
Goldberg NW, Shen X, Li J, Ritter T (2016) AlkylFluor: Deoxyfluorination of Alcohols. Organic lett 18: 6102–6104
6.
Ametamey SM, Honer M, Schubiger, PA (2008) Molecular Imaging with PET. Chem Rev 108: 1501–1516PubMed
7.
Neumann CN, Hooker JM, Ritter T (2016) Concerted nucleophilic aromatic substitution with 19F− and 18F−. Nature 534: 369–373PubMedPubMedCentral
8.
Neumann CN, Ritter T (2015) Late-stage fluorination: fancy novelty or useful tool? Angewandte Chemie 54: 3216–3221PubMed
Metadata
Title
PhenoFluor Deoxofluorination
Authors
Shuo Guo
Pingping Tang
Copyright Year
2020
Publisher
Springer Singapore
Book
Fluorination

Print ISBN: 978-981-10-3895-2

Electronic ISBN: 978-981-10-3896-9

Copyright Year: 2020

DOI
https://doi.org/10.1007/978-981-10-3896-9_10

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