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2015 | OriginalPaper | Chapter

7. Pin-Limited Cyberphysical Microfluidic Biochip

Authors : Yan Luo, Krishnendu Chakrabarty, Tsung-Yi Ho

Published in: Hardware/Software Co-Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips

Publisher: Springer International Publishing

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Abstract

On a digital microfluidic biochip, the number of control pins used to drive electrodes is a major contributor to the fabrication cost [1]. The layout of a typical biochip is shown in Fig. 7.1a, it has three regions:
1.
Active region, where the biochemistry assays are executed; electrodes and on-chip reservoirs are fabricated in this region.
 
2.
Contact region, where the contact pads of the input pins are fabricated. Here each contact pad corresponds to one input pin of the biochip. In order to reduce the contact resistance, the area of each pad is usually larger than an electrode [1].
 
3.
Wire routing region, where metal wires are fabricated. The wires connect electrodes to the contact pads of the input pins.
 

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previous chapter Pin-Count Minimization for Application-Independent Chips
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Literature
1.
K. Chakrabarty, R. Fair, and J. Zeng, “Design tools for digital microfluidic biochips: Towards functional diversification and more than Moore” (Keynote Paper), IEEE Trans. CAD, vol. 29, pp. 1001–1017, 2010.CrossRef
2.
C.-Y. Lin and Y.-W. Chang, “ILP-based pin-count aware design methodology for microfluidic biochips”, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, volume 29, Issue 9, pp. 1315–1327, 2010.CrossRef
3.
Y. Luo and K. Chakrabarty, “Design of pin-constrained general-purpose digital microfluidic biochips”, ACM/IEEE Design Automation Conference, pp. 18–25, 2012.
4.
5.
Z. Xiao and E. Young, “CrossRouter: A droplet router for cross-referencing digital microfluidic biochips”, IEEE/ACM Asia South Pacific Design Automation Conference, pp. 269–274, 2010.
6.
Y.-Y. Lin, E. Welch, and R. Fair, “Low voltage picoliter droplet manipulation utilizfing electrowetting-on-dielectric platforms”, Sensors and Actuators, B: Chemical, vol. 173, pp. 338–345, 2012.
7.
J. Gao, X. Liu, T. Chen, P.-I. Mak, Y. Du, M. Vai, B. Lin, and R. Martins, “An intelligent digital microfluidic system with fuzzy enhanced feedback for multi-droplet manipulation”, Lab on a Chip, Issue 13, volume 13, 2013.
8.
T. Xu and K. Chakrabarty, “Droplet-trace-based array partitioning and a pin assignment algorithm for the automated design of digital microfluidic biochips”, Proc. IEEE/ACM International Conference on Hardware/Software Codesign and System Synthesis, pp. 112–117, 2006.
9.
T.-W. Huang, J.-W. Chang, and T.-Y. Ho, “Integrated fluidic-chip co-design methodology for digital microfluidic biochips”, Proceedings of ACM International Symposium on Physical Design, pp. 49–56, 2012.
Metadata
Title
Pin-Limited Cyberphysical Microfluidic Biochip
Authors
Yan Luo
Krishnendu Chakrabarty
Tsung-Yi Ho
Copyright Year
2015
Book
Hardware/Software Co-Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips

Print ISBN: 978-3-319-09005-4

Electronic ISBN: 978-3-319-09006-1

Copyright Year: 2015

DOI
https://doi.org/10.1007/978-3-319-09006-1_7