Skip to main content
Disciplines
Automotive Business IT + Informatics Construction + Real Estate Electrical Engineering + Electronics Energy + Sustainability Insurance + Risk Finance + Banking Management + Leadership Marketing + Sales Mechanical Engineering + Materials
Events
DE
EN
Books
Journals
Topic Page
Marketing
Start single access now
Access for companies
EXTENDED SEARCH
Log in
Top
Published in:
Polymer Chemistry and Synthetic Polymers Read chapter Read first chapter

2015 | OriginalPaper | Chapter

14. Polymers in Wound Repair

Authors : Antonio Francesko, Margarida M. Fernandes, Guillem Rocasalbas, Sandrine Gautier, Tzanko Tzanov

Published in: Advanced Polymers in Medicine

Publisher: Springer International Publishing

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Efficient dermal wound care implies providing a healing environment at the site of injury. Current repair techniques, including polymeric dressings, are able to accelerate only the healing of epidermal and partial thickness acute wounds based on maintaining the area moist. However, these are not efficient in treatment of full-thickness and chronic wounds, which lack in inborn regenerative elements and are highly prone to infections. For this reason the research interest is nowadays shifted towards functional biomaterials to tackle severe skin deteriorations by providing a beneficiary for healing pro-active and pathogen-free environment. Recent advances in molecular biology and materials science together with better understanding of wound pathophysiology allowed for designing of new wound care approaches that rely on biochemical stimuli to promote wound closure. Biopolymers that couple intrinsic antimicrobial and wound repair properties with hydrophilicity appear as suitable dressing platforms. These can be further upgraded using various bio-entities (therapeutic molecules, cells) with the ability to address specific targets in the biochemical environment of wounds in order to stimulate the healing process. This chapter summarises the abundant experimental and clinical data on polymers in advanced wound dressings, scaffolds for dermal regeneration and platforms for drug delivery.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

inform now
previous chapter Polymers in Nephrology
next chapter Polymers in Cardiology
Literature
1.
Lazarus, G.S., et al.: Definitions and guidelines for assessment of wounds and evaluation of healing. Wound Repair Regener. 2(3), 165–170 (1994)
2.
Stadelmann, W.K., Digenis, A.G., Tobin, G.R.: Physiology and healing dynamics of chronic cutaneous wounds. Am. J. Surg. 176(2, Supplement 1): 26S–38S (1998)
3.
Weiss, S.J.: Tissue destruction by neutrophils. N. Engl. J. Med. 320(6), 365–376 (1989)
4.
Martin, P., Leibovich, S.J.: Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 15(11), 599–607 (2005)
5.
Diegelmann, R.F.: Excessive neutrophils characterize chronic pressure ulcers. Wound Repair Regener. 11(6), 490–495 (2003)
6.
Trengove, N.J., et al.: Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Repair Regener. 7(6), 442–452 (1999)
7.
Wang, Y., et al.: Myeloperoxidase inactivates timp-1 by oxidizing its n-terminal cysteine residue. J. Biol. Chem. 282(44), 31826–31834 (2007)
8.
Saarialho-Kere, U.K.: Patterns of matrix metalloproteinase and TIMP expression in chronic ulcers. Arch. Dermatol. Res. 290(1), S47–S54 (1998)
9.
Falabella, A.F.: Debridement and wound bed preparation. Dermatol. Ther. 19(6), 317–325 (2006)
10.
Boateng, J.S., et al.: Wound healing dressings and drug delivery systems: a review. J. Pharm. Sci. 97(8), 2892–2923 (2008)
11.
Atiyeh, B.S., et al.: Effect of silver on burn wound infection control and healing: review of the literature. Burns 33(2), 139–148 (2007)
12.
Gupta, S., et al.: Guidelines for managing pressure ulcers with negative pressure wound therapy. Adv. Skin Wound Care 17, 1–16 (2004)
13.
Xie, X., McGregor, M., Dendukuri, N.: The clinical effectiveness of negative pressure wound therapy: a systematic review. J. wound care 19(11), 490–495 (2010)
14.
Noble-Bell, G., Forbes, A.: A systematic review of the effectiveness of negative pressure wound therapy in the management of diabetes foot ulcers. Int. Wound J. 5(2), 233–242 (2008)
15.
Ubbink Dirk, T., et al.: Topical negative pressure for treating chronic wounds. Cochrane Database Syst. Rev. 16 (2008). doi: CD001898
16.
Suslick, K.S., Grinstaff, M.W.: Protein microencapsulation of nonaqueous liquids. J. Am. Chem. Soc. 112(21), 7807–7809 (1990)
17.
Ennis, W.J., et al.: Evaluation of clinical effectiveness of mist ultrasound therapy for the healing of chronic wounds. Adv. Skin Wound Care: J. Prev. Healing 19(8), 437–446 (2006)
18.
Francesko, A., Tzanov, T.: Chitin, chitosan and derivatives for wound healing and tissue engineering. In: Nyanhongo, G.S., Steiner, W., Gübitz, G. (eds.) Biofunctionalization of Polymers and their Applications, pp. 1–27. Springer, Berlin (2011)
19.
Queen, D., et al.: A dressing history. Int. Wound J. 1(1), 59–77 (2004)
20.
Mogoşanu, G.D., Grumezescu, A.M.: Natural and synthetic polymers for wounds and burns dressing. Int. J. Pharm. 463(2), 127–136 (2014)
21.
Wright, K.A., et al.: Alternative delivery of keratinocytes using a polyurethane membrane and the implications for its use in the treatment of full-thickness burn injury. Burns 24(1), 7–17 (1998)
22.
Jansson, E., Tengvall, P.: In vitro preparation and ellipsometric characterization of thin blood plasma clot films on silicon. Biomaterials 22(13), 1803–1808 (2001)
23.
Losi, P., et al.: Luminal surface microgeometry affects platelet adhesion in small-diameter synthetic grafts. Biomaterials 25(18), 4447–4455 (2004)
24.
Whelan, J.: Smart bandages diagnose wound infection. Drug Discov. Today 7(1), 9–10 (2002)
25.
Van den Kerckhove, E., et al.: Silicones in the rehabilitation of burns: a review and overview. Burns 27(3), 205–214 (2001)
26.
Raphael, K.G., et al.: Self-reported systemic, immune-mediated disorders in patients with and without proplast-teflon implants of the temporomandibular joint. J. Oral Maxillofac. Surg. 57(4), 364–370 (1999)
27.
Kim, I.-Y., et al.: Chitosan and its derivatives for tissue engineering applications. Biotechnol. Adv. 26(1), 1–21 (2008)
28.
Ueno, H., et al.: Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs. Biomaterials 20(15), 1407–1414 (1999)
29.
Wedmore, I., et al.: A special report on the chitosan-based hemostatic dressing: experience in current combat operations. J. Trauma Acute Care Surg. 60(3), 655–658 (2006)
30.
Pietramaggiori, G., et al.: Effects of poly-N-acetyl glucosamine (pGlcNAc) patch on wound healing in db/db mouse. J. Trauma Acute Care Surg. 64(3), 803–808 (2008)
31.
Dhanasingh, A., et al.: Tailored hyaluronic acid hydrogels through hydrophilic prepolymer cross-linkers. Soft Matter 6(3), 618–629 (2010)
32.
Gilbert, M.E., et al.: Chondroitin sulfate hydrogel and wound healing in rabbit maxillary sinus mucosa. Laryngoscope 114(8), 1406–1409 (2004)
33.
West, D., et al.: Angiogenesis induced by degradation products of hyaluronic acid. Science 228(4705), 1324–1326 (1985)
34.
Perng, C.-K., et al.: In vivo angiogenesis effect of porous collagen scaffold with hyaluronic acid oligosaccharides. J. Surg. Res. 168(1), 9–15 (2011)
35.
Park, S.-N., et al.: Biological characterization of EDC-crosslinked collagen–hyaluronic acid matrix in dermal tissue restoration. Biomaterials 24(9), 1631–1641 (2003)
36.
Luo, Y., Kirker, K.R., Prestwich, G.D.: Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J. Controlled Release 69(1), 169–184 (2000)
37.
Lin, Y.-C., et al.: Synthesis and characterization of collagen/hyaluronan/chitosan composite sponges for potential biomedical applications. Acta Biomater. 5(7), 2591–2600 (2009)
38.
Chang, C.-H., et al.: Gelatin–chondroitin–hyaluronan tri-copolymer scaffold for cartilage tissue engineering. Biomaterials 24(26), 4853–4858 (2003)
39.
Dumville, J., et al., Alginate dressings for healing diabetic foot ulcers. Cochrane Database Syst. Rev. 15(2) (2012)
40.
Cen, L., et al.: Collagen tissue engineering: development of novel biomaterials and applications. Pediatr. Res. 63(5), 492–496 (2008)
41.
Parenteau-Bareil, R., Gauvin, R., Berthod, F.: Collagen-based biomaterials for tissue engineering applications. Materials 3(3), 1863–1887 (2010)
42.
Ruszczak, Z., Friess, W.: Collagen as a carrier for on-site delivery of antibacterial drugs. Adv. Drug Deliv. Rev. 55(12), 1679–1698 (2003)
43.
Cullen, B., et al.: Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers. Wound Repair Regener. 10(1), 16–25 (2002)
44.
Cullen, B., et al.: The role of oxidised regenerated cellulose/collagen in chronic wound repair and its potential mechanism of action. Int. J. Biochem. Cell Biol. 34(12), 1544–1556 (2002)
45.
Rothwell, S., et al.: Wound healing and the immune response in swine treated with a hemostatic bandage composed of salmon thrombin and fibrinogen. J. Mater. Sci. Mater. Med. 20(10), 2155–2166 (2009)
46.
Vasconcelos, A., Cavaco-Paulo, A.: Wound dressings for a proteolytic-rich environment. Appl. Microbiol. Biotechnol. 90(2), 445–460 (2011)
47.
de Moraes, M.A., Beppu, M.M.: Biocomposite membranes of sodium alginate and silk fibroin fibers for biomedical applications. J. Appl. Polym. Sci. 130(5), 3451–3457 (2013)
48.
Liu, T.-L., et al.: Cytocompatibility of regenerated silk fibroin film: a medical biomaterial applicable to wound healing. J. Zhejiang Univ. Sci. B 11(1), 10–16 (2010)
49.
Zhu, X., et al.: Activation of T lymphocytes on local trauma after implantation of regenerated porous silk fibroin film. J. Clim. Rehabil. Tissue Eng. Res. 15, 7061–7065 (2011)
50.
Dror, Y., et al.: Nanofibers made of globular proteins. Biomacromolecules 9(10), 2749–2754 (2008)
51.
Jin, R., et al.: Injectable chitosan-based hydrogels for cartilage tissue engineering. Biomaterials 30(13), 2544–2551 (2009)
52.
Sibbald, R.G., Woo, K.Y., Queen, D.: Wound bed preparation and oxygen balance—a new component? Int. Wound J. 4, 9–17 (2007)
53.
Werner, S., Grose, R.: Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 83(3), 835–870 (2003)
54.
Barrientos, S., et al.: Perspective article: growth factors and cytokines in wound healing. Wound Repair Regener. 16(5), 585–601 (2008)
55.
Steed, D.L., Study Group, t.D.U.*: Clinical evaluation of recombinant human platelet—derived growth factor for the treatment of lower extremity diabetic ulcers. J. Vasc. Surg. 21(1), 71–81 (1995)
56.
Anitua, E., et al.: Platelet-rich plasma: preparation and formulation. Operative Tech. Orthop. 22(1), 25–32 (2012)
57.
Vande Berg, J., Robson, M., Mikhail, R.: Extension of the life span of pressure ulcer fibroblasts with recombinant human interleukin-1 beta. Am. J. Pathol. 146(5), 1273–1282 (1995)
58.
Cianfarani, F., et al.: Granulocyte/macrophage colony-stimulating factor treatment of human chronic ulcers promotes angiogenesis associated with de novo vascular endothelial growth factor transcription in the ulcer bed. Br. J. Dermatol. 154(1), 34–41 (2006)
59.
Da Costa, R.M., et al.: Randomized, double-blind, placebo-controlled, dose- ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers. Wound Repair Regener. 7(1), 17–25 (1999)
60.
Cruciani, M., et al.: Are granulocyte colony-stimulating factors beneficial in treating diabetic foot infections?: a meta-analysis. Diabetes Care 28(2), 454–460 (2005)
61.
Kavanaugh, A.: Combination cytokine therapy: the next generation of rheumatoid arthritis therapy? Arthritis Care Res. 47(1), 87–92 (2002)
62.
Pellegrini, M., Mak, T., Ohashi, P.: Fighting cancers from within: augmenting tumor immunity with cytokine therapy. Trends Pharmacol. Sci. 31(8), 356–363 (2010)
63.
Lansdown, A.B.G.: Silver 2: toxicity in mammals and how its products aid wound repair. J. Wound Care 11(5), 173–177 (2002)
64.
Howell-Jones, R.S., et al.: A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. J. Antimicrob. Chemother. 55(2), 143–149 (2005)
65.
Landsdown, A., Williams, A.: Bacterial resistance to silver in wound care and medical devices. J Wound Care 16(1), 15–19 (2007)
66.
Gilbert, P.: Avoiding the resistance pitfall in infection control. Does the use of antiseptic products contribute to the spread of antibiotic resistance? Ostomy Wound Manage 52(10 A Suppl): 1S–3S (2006)
67.
Giles, N.M., et al.: Metal and redox modulation of cysteine protein function. Chem. Biol. 10(8), 677–693 (2003)
68.
Gu, Z., et al.: S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 297(5584), 1186–1190 (2002)
69.
Andreassen, O.A., et al.: N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. NeuroReport 11(11), 2491–2493 (2000)
70.
Fu, X., et al.: Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). J. Biol. Chem. 276(44), 41279–41287 (2001)
71.
Van Antwerpen, P., et al.: Thiol-containing molecules interact with the myeloperoxidase/H2O2/chloride system to inhibit LDL oxidation. Biochem. Biophys. Res. Commun. 337(1), 82–88 (2005)
72.
Rice-Evans, C.A., Miller, N.J., Paganga, G.: Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 20(7), 933–956 (1996)
73.
Mira, L., et al.: Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic. Res. 36(11), 1199–1208 (2002)
74.
Pauff, J.M., Hille, R.: Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin. J. Nat. Prod. 72(4), 725–731 (2009)
75.
Ding, Z., et al.: Anti-inflammatory effects of scopoletin and underlying mechanisms. Pharm. Biol. 46(12), 854–860 (2008)
76.
Geyid, A., et al.: Screening of some medicinal plants of Ethiopia for their anti-microbial properties and chemical profiles. J. Ethnopharmacol. 97(3), 421–427 (2005)
77.
Kim, H., et al.: Enhanced wound healing by an epigallocatechin gallate-incorporated collagen sponge in diabetic mice. Wound Repair Regener. 16(5), 714–720 (2008)
78.
Masaki, H., Atsumi, T., Sakurai, H.: Protective activity of hamamelitannin on cell damage of murine skin fibroblasts induced by UVB irradiation. J. Dermatol. Sci. 10(1), 25–34 (1995)
79.
Deters, A., et al.: High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin. Phytochemistry 58(6), 949–958 (2001)
80.
Kato, Y., et al.: Inhibition of myeloperoxidase-catalyzed tyrosylation by phenolic antioxidants in vitro. Biosci. Biotechnol. Biochem. 67(5), 1136–1139 (2003)
81.
Madhan, B., et al.: Role of green tea polyphenols in the inhibition of collagenolytic activity by collagenase. Int. J. Biol. Macromol. 41(1), 16–22 (2007)
82.
Chen, R., Mooney, D.: Polymeric growth factor delivery strategies for tissue engineering. Pharm. Res. 20(8), 1103–1112 (2003)
83.
Lee, K., Silva, E.A., Mooney, D.J.: Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J. R. Soc. Interface 8(55), 153–170 (2011)
84.
Koria, P.: Delivery of growth factors for tissue regeneration and wound healing. BioDrugs 26(3), 163–175 (2012)
85.
Ulubayram, K., et al.: EGF containing gelatin-based wound dressings. Biomaterials 22(11), 1345–1356 (2001)
86.
Kolambkar, Y.M., et al.: An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. Biomaterials 32(1), 65–74 (2011)
87.
Değim, Z.: Use of microparticulate systems to accelerate skin wound healing. J. Drug Target. 16(6), 437–448 (2008)
88.
Takemoto, S., et al.: Preparation of collagen/gelatin sponge scaffold for sustained release of bFGF. Tissue Eng. Part A 14(10), 1629–1638 (2008)
89.
Matsumoto, Y., Kuroyanagi, Y.: Development of a wound dressing composed of hyaluronic acid sponge containing arginine and epidermal growth factor. J. Biomater. Sci. Polym. Ed. 21(6), 126–715 (2010)
90.
Huang, S., et al.: Wound dressings containing bFGF-impregnated microspheres. J. Microencapsul. 23(3), 277–290 (2006)
91.
Kakagia, D.D., et al.: Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial. J. Diabetes Complications 21(6), 387–391 (2007)
92.
Leaper, D.J.: Silver dressings: their role in wound management. Int. Wound J. 3(4), 282–294 (2006)
93.
Leaper, D.: Silver dressings: their role in wound management. Int Wound J. 3(4), 282–294 (2006)
94.
Fong, J., Wood, F.: Nanocrystalline silver dressings in wound management: a review. Int. J. Nanomed. 1(4), 441–449 (2006)
95.
Rutten, H., Nijhuis, P.: Prevention of wound infection in elective colorectal surgery by local application of a gentamicin-containing collagen sponge. Eur. J. Surg. Suppl. 578, 31–35 (1997)
96.
Sawada, Y., et al.: Treatment of dermal depth burn wounds with an antimicrobial agent-releasing silicone gel sheet. Burns 16(5), 347–352 (1990)
97.
Sawada, Y., et al.: An evaluation of a new lactic acid polymer drug delivery system: a preliminary report. Br. J. Plast. Surg. 47(3), 158–161 (1994)
98.
Galandiuk, S., et al.: Absorbable, delayed-release antibiotic beads reduce surgical wound infection. Am. Surg. 63(9), 831–835 (1997)
99.
Aoyagi, S., Onishi, H., Machida, Y.: Novel chitosan wound dressing loaded with minocycline for the treatment of severe burn wounds. Int. J. Pharm. 330(1–2), 138–145 (2007)
100.
Kingsley, A., et al.: Suprasorb X + PHMB: antimicrobial and HydroBalance action in a new wound dressing. Wounds UK 5(1), 72–77 (2009)
101.
Glover, D., Wicks, G.: Suprasorb X + PHMB: the clinical evidence. J. wound care. ACTIVA healthcare Supplement, 15–21 (2009)
102.
Elzinga, G., et al.: Clinical evaluation of a PHMB-impregnated biocellulose dressing on paediatric lacerations. J Wound Care 20(6), 280–284 (2011)
103.
Antonio, F., et al.: Cross-linked collagen sponges loaded with plant polyphenols with inhibitory activity towards chronic wound enzymes. Biotechnol. J. 6(10), 1208–1218 (2011)
104.
Díaz-GonzáLez, M., et al.: Inhibition of deleterious chronic wound enzymes with plant polyphenols. Biocatal. Biotransform. 30(1), 102–110 (2012)
105.
Haslam, E.: natural polyphenols (vegetable tannins) as drugs: possible modes of action. J. Nat. Prod. 59(2), 205–215 (1996)
106.
Madhan, B., et al.: Stabilization of collagen using plant polyphenol: role of catechin. Int. J. Biol. Macromol. 37(1–2), 47–53 (2005)
107.
Tang, H.R., Covington, A.D., Hancock, R.A.: Structure–activity relationships in the hydrophobic interactions of polyphenols with cellulose and collagen. Biopolymers 70(3), 403–413 (2003)
108.
Francesko, A., et al.: Functional biopolymer-based matrices for modulation of chronic wound enzyme activities. Acta Biomater. 9(2), 5216–5225 (2013)
109.
Rocasalbas, G., et al.: Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols. Carbohydr. Polym. 92(2), 989–996 (2013)
110.
Roldo, M., et al.: Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation. Eur. J. Pharm. Biopharm. 57(1), 115–121 (2004)
111.
Föger, F., Schmitz, T., Bernkop-Schnürch, A.: In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. Biomaterials 27(23), 4250–4255 (2006)
112.
Kast, C.E., et al.: Chitosan-thioglycolic acid conjugate: a new scaffold material for tissue engineering? Int. J. Pharm. 256(1–2), 183–189 (2003)
113.
Kast, C.E., Bernkop-Schnürch, A.: Thiolated polymers—thiomers: development and in vitro evaluation of chitosan–thioglycolic acid conjugates. Biomaterials 22(17), 2345–2352 (2001)
114.
Francesko, A., et al.: GAGs-thiolated chitosan assemblies for chronic wounds treatment: control of enzyme activity and cell attachment. J. Mater. Chem. 22(37), 19438–19446 (2012)
Metadata
Title
Polymers in Wound Repair
Authors
Antonio Francesko
Margarida M. Fernandes
Guillem Rocasalbas
Sandrine Gautier
Tzanko Tzanov
Copyright Year
2015
Book
Advanced Polymers in Medicine

Print ISBN: 978-3-319-12477-3

Electronic ISBN: 978-3-319-12478-0

Copyright Year: 2015

DOI
https://doi.org/10.1007/978-3-319-12478-0_14

Premium Partners

    Image Credits