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Colloid and Polymer Science

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01-11-2009 | Original Contribution

Polypeptide hybrid copolymers as selective micellar nanocarriers in nonaqueous media

Authors: Guillermo Orts Gil, Sylvain Prévost, Magdalena Łosik, Florian Hermes, Helmut Schlaad, Thomas Hellweg

Published in: Colloid and Polymer Science | Issue 11/2009

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Abstract

The self-assembly of polystyrene-block-poly(l-lysine) (PS-PLLys·HCl) copolymers with different block lengths has been studied in toluene. The obtained spherical micelles exhibit size variations upon addition of acids or bases, as indicated by light and neutron scattering studies. It is shown that pyridine induces a shrinking of the polystyrene chains in the corona region of the micelles, decreasing the aggregate solvent interface. The addition of benzoic acid, on the other hand, leads to a swelling of the copolymer micelles proportional to the molar fraction of polypeptide. This behavior suggests a selective permeability of the PS-PLLys micelles and the possibility to encapsulate organic compounds in toluene depending on their chemical nature.

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Title: Polypeptide hybrid copolymers as selective micellar nanocarriers in nonaqueous media
Authors: Guillermo Orts Gil
Sylvain Prévost
Magdalena Łosik
Florian Hermes
Helmut Schlaad
Thomas Hellweg
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: Colloid and Polymer Science / Issue 11/2009
Print ISSN: 0303-402X
Electronic ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-009-2096-y

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