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Published in: Cellulose 3/2022

13-01-2022 | Original Research

Porous cellulose microspheres coated in one step with a polydopamine suspension of hydroxyapatite for bone tissue engineering

Authors: Fei Gao, Dong Zeng, Hong Liu, Rui Qin, Jie Zhang, Yingming Chen, Weiming Wang, Chuang Peng, Ming Li, Qing Li, Hong Wang, Shuai Peng

Published in: Cellulose | Issue 3/2022

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Abstract

Deacetylated porous cellulose acetate microspheres (DPCA) modified with hydroxyapatite (HA) penetrated polydopamine (PDA) coating was prepared by a one-step in-situ method and investigated as the scaffold for bone tissue regeneration. The physical and chemical properties of different scaffolds were analyzed by Scanning electron microscopy, Transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and X-ray photoelectron spectrum. Test results proved the unique three-dimensional porous structure, homogeneous PDA coating, dispersive HA crystals of the DPCA-PDA-HA microspheres (DPPH). The excellent attachment, adhesion and proliferation of MC3T3-E1 preosteoblast on DPPH were manifested by cell adhesion and biocompatibility assessment. In vitro mineralization also shown MC3T3-E1 was capable of differentiating osteogenically. Such satisfactory biomedical performance of DPPH was ascribed to the one-step introducing process contributing to a uniform and enrich growth of HA on the microspheres surface and interior. This study provides a promising cellulose-based scaffold applied in bone regeneration field.

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Appendix
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Literature
go back to reference Peng S, Meng HC, Ouyang Y, Chang J (2014) Nanoporous magnetic cellulose-chitosan composite microspheres: preparation, characterization, and application for Cu (II) adsorption. Ind Eng Chem Res 53:2106–2113CrossRef Peng S, Meng HC, Ouyang Y, Chang J (2014) Nanoporous magnetic cellulose-chitosan composite microspheres: preparation, characterization, and application for Cu (II) adsorption. Ind Eng Chem Res 53:2106–2113CrossRef
Metadata
Title
Porous cellulose microspheres coated in one step with a polydopamine suspension of hydroxyapatite for bone tissue engineering
Authors
Fei Gao
Dong Zeng
Hong Liu
Rui Qin
Jie Zhang
Yingming Chen
Weiming Wang
Chuang Peng
Ming Li
Qing Li
Hong Wang
Shuai Peng
Publication date
13-01-2022
Publisher
Springer Netherlands
Published in
Cellulose / Issue 3/2022
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI
https://doi.org/10.1007/s10570-021-04395-4

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