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Journal of Nanoparticle Research

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01-04-2013 | Research Paper

Protective effect of quercetin and/or l-arginine against nano-zinc oxide-induced cardiotoxicity in rats

Authors: L. M. Faddah, Nayira A. Abdel Baky, Azza M. Mohamed, Nouf M. Al-Rasheed, Nawal M. Al-Rasheed

Published in: Journal of Nanoparticle Research | Issue 4/2013

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Abstract

The aim of this study was to investigate the protective role of quercetin and/or l-arginine against the cardiotoxic potency of zinc oxide nanoparticle (ZnO-NP)-induced cardiac infarction. ZnO-NPs (50 nm) were administered orally at either 600 mg or 1 g/kg body weight for 5 consecutive days. The results revealed that co-administration of quercetin and/or l-arginine (each 200 mg/kg body weight) daily for 3 weeks to rats intoxicated by either of the two doses markedly ameliorated increases in serum markers of cardiac infarction, including troponin T, creatine kinase-MB, and myoglobin, as well as increases in proinflammatory biomarkers, including tumor necrosis factor-α, interleukin-6, and C-reactive protein, compared with intoxicated, untreated rats. Each agent alone or in combination also successfully modulated the alterations in serum vascular endothelial growth factor, cardiac calcium concentration, and oxidative DNA damage as well as the increase in the apoptosis marker caspase 3 of cardiac tissue in response to ZnO-NP toxicity. In conclusion, early treatment with quercetin and l-arginine may protect cardiac tissue from infarction induced by the toxic effects of ZnO-NPs.

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Title: Protective effect of quercetin and/or l-arginine against nano-zinc oxide-induced cardiotoxicity in rats
Authors: L. M. Faddah
Nayira A. Abdel Baky
Azza M. Mohamed
Nouf M. Al-Rasheed
Nawal M. Al-Rasheed
Publication date: 01-04-2013
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 4/2013
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-013-1520-x

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