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Published in:
2022 | OriginalPaper | Chapter
21. Q & A
Author : Peter McCullagh
Published in: Ten Projects in Applied Statistics
Publisher: Springer International Publishing
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Abstract
This chapter offers an informal discussion in Q & A format of some of the concepts introduced in Chap. 11.
The discussion begins with the design protocol and the specification of the population. Does the population exist pre-baseline? Is it finite or infinite? Is the sample a fixed subset or a random subset? In the case of a clinical trial, which patients are included in the population? Why should tomorrow’s population be included? Is a sequentially-recruited sample fixed or random? What is the role of finite-population random sampling? What does the population of all plots look like in an agricultural field setting? Do agricultural field trials use random samples?
Why is baseline so important? What happens pre-baseline? What is the distinction between a covariate and a relationship? What is the distinction between a classification factor and a block factor? What is the purpose of a covariate? Is treatment a covariate? Where does exchangeability come in? Is exchangeability a matter of fact or is it a mathematical theorem? Is the randomization distribution always uniform? What is the role of counterfactuals?