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Quality of Life Research

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14-11-2015 | Review

Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes

Authors: Shantanu N. Razdan, Vishal Patel, Sarah Jewell, Colleen M. McCarthy

Published in: Quality of Life Research | Issue 6/2016

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Abstract

Purpose

Bilateral prophylactic mastectomy (BPM) is effective in reducing the risk of breast cancer in women with a well-defined family history of breast cancer or in women with BRCA 1 or 2 mutations. Evaluating patient-reported outcomes following BPM are thus essential for evaluating success of BPM from patient’s perspective. Our systematic review aimed to: (1) identify studies describing health-related quality of life (HRQOL) in patients following BPM with or without reconstruction; (2) assess the effect of BPM with or without reconstruction on HRQOL; and (3) identify predictors of HRQOL post-BPM.

Methods

We performed a systematic review of literature using the PRISMA guidelines. PubMed, Embase, PsycINFO, Web of Science, Scopus and Cochrane databases were searched.

Results

The initial search resulted in 1082 studies; 22 of these studies fulfilled our inclusion criteria. Post-BPM, patients are satisfied with the outcomes and report high psychosocial well-being and positive body image. Sexual well-being and somatosensory function are most negatively affected. Vulnerability, psychological distress and preoperative cancer distress are significant negative predictors of quality of life and body image post-BPM.

Conclusion

There is a paucity of high-quality data on outcomes of different HRQOL domains post-BPM. Future studies should strive to use validated and breast-specific PRO instruments for measuring HRQOL. This will facilitate shared decision-making by enabling surgeons to provide evidence-based answers to women contemplating BPM.

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Title: Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes
Authors: Shantanu N. Razdan
Vishal Patel
Sarah Jewell
Colleen M. McCarthy
Publication date: 14-11-2015
Publisher: Springer International Publishing
Published in: Quality of Life Research / Issue 6/2016
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-015-1181-6

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Abstract

Purpose

Methods

Results

Conclusion

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