Top

Published in:

15-02-2020

Quality of life may be a more valuable prognostic factor than depression in older hemodialysis patients

Authors: Saulo Barbosa Vasconcelos de Alencar, Luana do Amaral Dias, Victor do Amaral Dias, Fábia Maria de Lima, Ulisses Ramos Montarroyos, Kátia Cristina Lima de Petribú

Published in: Quality of Life Research | Issue 7/2020

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Purpose

Depression and impairment of quality of life (QoL) reduce the survival of individual on hemodialysis (HD). However, few studies evaluated the impact of these conditions on the survival of older patients undergoing HD.

Methods

A retrospective cohort study was performed including patients aged ≥ 60 years on HD in Recife, Brazil, assessed in 2013 and monitored until 2017. Depression was evaluated with the Mini-International Neuropsychiatric Interview and QoL with the Control, Autonomy, Self-realization, and Pleasure Questionnaire (CASP-16). Survival differences according to the depression and QoL status were measured by Kaplan–Meier analysis and Cox regression. Death Certificates were analyzed to assess the cause of death.

Results

A total of 171 patients were included (mean age 68.7 ± 6.9 years). The mean follow-up time was 3 years (maximum 4.5 years) and there were 98 deaths (57.3% of the sample). In a multivariate model that included depression and QoL, only QoL impairment was associated with a higher risk of death (HR 1.62, p = 0.035). Among CASP domains, only “Control” was associated with survival (HR 0.90, p = 0.014). Depression was unrelated to the cause of death, but there was a trend for death by endocrine diseases if QoL was impaired (p = 0.057).

Conclusion

QoL impairment is a key predictor of prognosis in older patients on HD and may be more important than depression. It is important that teams dealing with this population include in protocols an assessment of QoL, in order to offer a range of care according to the needs of these patients.

previous article Predictive model of variables associated with health-related quality of life in patients with advanced chronic kidney disease receiving hemodialysis

next article Self-esteem in patients with inflammatory bowel disease

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Kremers, W. K., Denic, A., Lieske, J. C., Alexander, M. P., Kaushik, V., Elsherbiny, H. E., et al. (2015). Distinguishing age-related from disease-related glomerulosclerosis on kidney biopsy: The Aging Kidney Anatomy study. Nephrology Dialysis Transplantation,30(12), 2034–2039. https://doi.org/10.1093/ndt/gfv072.CrossRefPubMedCentral

Kirkman, M. S., Briscoe, V. J., Clark, N., Florez, H., Haas, L. B., Halter, J. B., et al. (2012). Diabetes in older adults. Diabetes Care,35(12), 2650–2664. https://doi.org/10.2337/dc12-1801.CrossRefPubMedPubMedCentral

Sesso, R. C., Lopes, A. A., Thomé, F. S., Lugon, J. R., & Martins, C. T. (2017). Brazilian chronic dialysis survey 2016. Jornal Brasileiro de Nefrologia,39(3), 261–266. https://doi.org/10.5935/0101-2800.20170049.CrossRefPubMed

Kramer, A., Pippias, M., Noordzij, M., Stel, V. S., Andrusev, A. M., Aparicio-Madre, M. I., et al. (2019). The European renal association—European dialysis and transplant association (ERA-EDTA) Registry Annual Report 2016: A summary. Clinical Kidney Journal. https://doi.org/10.1093/ckj/sfz011.CrossRefPubMedPubMedCentral

United States Renal Data System. 2018 USRDS annual data report. (2018). Chapter 1: Incidence, prevalence, patient characteristics, and treatment modalities. American Journal of Kidney Diseases, 71(3), S247–S276. https://doi.org/10.1053/j.ajkd.2018.01.014.

Martiny, C., de Oliveira e Silva, A. C., Neto, J. P. S., & Nardi, A. E. (2012). Psychiatric disorders in patients with end-stage renal disease. Journal of Renal Care,38(3), 131–137. https://doi.org/10.1111/j.1755-6686.2012.00261.x.CrossRefPubMed

Palmer, S., Vecchio, M., Craig, J. C., Tonelli, M., Johnson, D. W., Nicolucci, A., et al. (2013). Prevalence of depression in chronic kidney disease: Systematic review and meta-analysis of observational studies. Kidney International,84(1), 179–191. https://doi.org/10.1038/ki.2013.77.CrossRefPubMed

Alencar, S. B. V., de Lima, F. M., Dias, L. D. A., Dias, V. D. A., Lessa, A. C., Bezerra, J. M., et al. (2019). Depression and quality of life in older adults on hemodialysis. Brazilian Journal of Psychiatry. https://doi.org/10.1590/1516-4446-2018-0345.CrossRefPubMedPubMedCentral

Unruh, M. L., Newman, A. B., Larive, B., Dew, M. A., Miskulin, D. C., Greene, T., et al. (2008). The influence of age on changes in health-related quality of life over three years in a cohort undergoing hemodialysis. Journal of the American Geriatrics Society,56(9), 1608–1617. https://doi.org/10.1111/j.1532-5415.2008.01849.x.CrossRefPubMedPubMedCentral

10.

Lamping, D. L., Constantinovici, N., Roderick, P., Normand, C., Henderson, L., Harris, S., et al. (2000). Clinical outcomes, quality of life, and costs in the North Thames Dialysis Study of elderly people on dialysis: A prospective cohort study. Lancet,356(9241), 1543–1550. https://doi.org/10.1016/S0140-6736(00)03123-8.CrossRefPubMed

11.

Cruz, L. N., Fleck, M. P., & Polanczyk, C. A. (2010). Depression as a determinant of quality of life in patients with chronic disease: Data from Brazil. Social psychiatry and psychiatric epidemiology,45(10), 953–961. https://doi.org/10.1007/s00127-009-0141-2.CrossRefPubMed

12.

Balogun, R. A., Turgut, F., Balogun, S. A., Holroyd, S., & Abdel-Rahman, E. M. (2011). Screening for depression in elderly hemodialysis patients. Nephron Clinical Practice,118(2), c72–c77. https://doi.org/10.1159/000320037.CrossRefPubMed

13.

Chilcot, J., Guirguis, A., Friedli, K., Almond, M., Day, C., Da Silva-Gane, M., et al. (2018). Depression symptoms in haemodialysis patients predict all-cause mortality but not kidney transplantation: A cause-specific outcome analysis. Annals of Behavioral Medicine,52(1), 1–8. https://doi.org/10.1007/s12160-017-9918-9.CrossRefPubMed

14.

Palmer, S. C., Vecchio, M., Craig, J. C., Tonelli, M., Johnson, D. W., Nicolucci, A., et al. (2013). Association between depression and death in people with CKD: A meta-analysis of cohort studies. American Journal of Kidney Diseases,62(3), 493–505. https://doi.org/10.1053/j.ajkd.2013.02.369.CrossRefPubMed

15.

Zhou, X., Xue, F., Wang, H., Qiao, Y., Liu, G., Huang, L., et al. (2017). The quality of life and associated factors in patients on maintenance hemodialysis—A multicenter study in Shanxi province. Renal Failure,39(1), 707–711. https://doi.org/10.1080/0886022X.2017.1398095.CrossRefPubMedPubMedCentral

16.

Pan, C. W., Wu, Y., Zhou, H. J., Xu, B. X., & Wang, P. (2018). Health-related quality of life and its factors of hemodialysis patients in Suzhou China. Blood Purification,45(4), 327–333. https://doi.org/10.1159/000485962.CrossRefPubMed

17.

Farrokhi, F., Abedi, N., Beyene, J., Kurdyak, P., & Jassal, S. V. (2014). Association between depression and mortality in patients receiving long-term dialysis: A systematic review and meta-analysis. American Journal of Kidney Diseases,63(4), 623–635. https://doi.org/10.1053/j.ajkd.2013.08.024.CrossRefPubMed

18.

Van Loon, I. N., Bots, M. L., Boereboom, F. T. J., Grooteman, M. P. C., Blankestijn, P. J., Van Den Dorpel, M. A., et al. (2017). Quality of life as indicator of poor outcome in hemodialysis: Relation with mortality in different age groups. BMC Nephrology,18(1), 1–9. https://doi.org/10.1186/s12882-017-0621-7.CrossRef

19.

Hall, R. K., Luciano, A., Pieper, C., & Colón-Emeric, C. S. (2018). Association of kidney disease quality of life (KDQOL-36) with mortality and hospitalization in older adults receiving hemodialysis. BMC Nephrology,19(1), 11. https://doi.org/10.1186/s12882-017-0801-5.CrossRefPubMedPubMedCentral

20.

Rinaldi, P., Mecocci, P., Benedetti, C., Ercolani, S., Bregnocchi, M., Menculini, G., et al. (2003). Validation of the five-item geriatric depression scale in elderly subjects in three different settings. Journal of the American Geriatrics Society,51(5), 694–698. https://doi.org/10.1034/j.1600-0579.2003.00216.x.CrossRefPubMed

21.

Sheehan, D. V, Lecrubier, Y., Sheehan, K. H., Amorim, P., Janavs, J., Weiller, E., et al. (1998). The mini-international neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of clinical psychiatry, 59 (Suppl 2), 22–33; quiz 34-57. https://doi.org/10.1016/S0924-9338(99)80239-9

22.

Lima, F. M., Hyde, M., Chungkham, H. S., Correia, C., Siqueira Campos, A., Campos, M., et al. (2014). Quality of life amongst older Brazilians: A cross-cultural validation of the CASP-19 into Brazilian-Portuguese. PLoS ONE,9(4), 1–8. https://doi.org/10.1371/journal.pone.0094289.CrossRef

23.

Hyde, M., Wiggins, R. D., Higgs, P., & Blane, D. B. (2003). A measure of quality of life in early old age: The theory, development and properties of a needs satisfaction model (CASP-19). Aging & Mental Health,7(3), 186–194. https://doi.org/10.1080/1360786031000101157.CrossRef

24.

Hecking, M., Bieber, B. A., Ethier, J., Kautzky-Willer, A., Sunder-Plassmann, G., Säemann, M. D., et al. (2014). Sex-specific differences in hemodialysis prevalence and practices and the male-to-female mortality rate: The dialysis outcomes and practice patterns study (DOPPS). PLoS Medicine. https://doi.org/10.1371/journal.pmed.1001750.CrossRefPubMedPubMedCentral

25.

Eknoyan, G., Beck, G. J., Cheung, A. K., Daugirdas, J. T., Greene, T., Kusek, J. W., et al. (2002). Effect of dialysis dose and membrane flux in maintenance hemodialysis. New England Journal of Medicine,347(25), 2010–2019. https://doi.org/10.1056/NEJMoa021583.CrossRefPubMed

26.

Park, J.-M., Lee, J.-H., Jang, H. M., Park, Y., Kim, Y. S., Kang, S.-W., et al. (2018). Survival in patients on hemodialysis: Effect of gender according to body mass index and creatinine. PLoS ONE,13(5), e0196550. https://doi.org/10.1371/journal.pone.0196550.CrossRefPubMedPubMedCentral

27.

Ebrahimi, V., Khademian, M. H., Masoumi, S. J., Morvaridi, M. R., & Ezzatzadegan Jahromi, S. (2019). Factors influencing survival time of hemodialysis patients; Time to event analysis using parametric models: A cohort study. BMC Nephrology,20(1), 1–9. https://doi.org/10.1186/s12882-019-1382-2.CrossRef

28.

Tuǧcu, M., Kasapoǧlu, U., Şahin, G., & Apaydin, S. (2018). The factors affecting survival in geriatric hemodialysis patients. International Journal of Nephrology. https://doi.org/10.1155/2018/5769762.CrossRefPubMedPubMedCentral

29.

Balogun, R. A., Balogun, S. A., Kepple, A. L., Ma, J. Z., Turgut, F., Kovesdy, C. P., et al. (2011). The 15-item geriatric depression scale as a predictor of mortality in older adults undergoing hemodialysis. Journal of the American Geriatrics Society,59(8), 1563–1565. https://doi.org/10.1111/j.1532-5415.2011.03533.x.CrossRefPubMed

30.

Genestier, S., Meyer, N., Chantrel, F., Alenabi, F., Brignon, P., Maaz, M., et al. (2010). Prognostic survival factors in elderly renal failure patients treated with peritoneal dialysis: A nine-year retrospective study. Peritoneal Dialysis International,30(2), 218–226. https://doi.org/10.3747/pdi.2009.00043.CrossRefPubMed

31.

Gilman Scd, S. E., Sucha, E., Kingsbury, M., Scd, N. J. H., Murphy, J. M., & Colman, I. (2017). Depression and mortality in a longitudinal study: 1952–2011. CMAJ,189, 1304–1314. https://doi.org/10.1503/cmaj.170125.CrossRef

32.

Liu, Y., Ho, R. C.-M., & Mak, A. (2012). Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression. Journal of Affective Disorders,139(3), 230–239. https://doi.org/10.1016/j.jad.2011.08.003.CrossRefPubMed

33.

Ryan, J., Pilkington, L., Neuhaus, K., Ritchie, K., Ancelin, M. L., & Saffery, R. (2017). Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression. BMC Psychiatry,17(1), 1–7. https://doi.org/10.1186/s12888-017-1515-8.CrossRef

34.

Wei, J., Fan, L., Zhang, Y., Li, S., Partridge, J., Claytor, L., et al. (2018). Association between malnutrition and depression among community-dwelling older Chinese adults. Asia Pacific Journal of Public Health,30(2), 107–117. https://doi.org/10.1177/1010539518760632.CrossRefPubMed

35.

Allawi, A. A. D. (2018). Malnutrition, inflamation and atherosclerosis (MIA syndrome) in patients with end stage renal disease on maintenance hemodialysis (a single centre experience). Diabetes & Metabolic Syndrome: Clinical Research & Reviews,12(2), 91–97. https://doi.org/10.1016/j.dsx.2017.09.003.CrossRef

36.

Vaccarino, V., Badimon, L., Bremner, J. D., Cenko, E., Cubedo, J., Dorobantu, M., et al. (2019). Depression and coronary heart disease: 2018 ESC position paper of the working group of coronary pathophysiology and microcirculation developed under the auspices of the ESC Committee for Practice Guidelines. European Heart Journal. https://doi.org/10.1093/eurheartj/ehy913.CrossRefPubMedPubMedCentral

37.

Chen, I. M., Lin, P. H., Wu, V. C., Wu, C. S., Shan, J. C., Chang, S. S., et al. (2017). Suicide deaths among patients with end-stage renal disease receiving dialysis: A population-based retrospective cohort study of 64,000 patients in Taiwan. Journal of Affective Disorders,227(17), 7–10. https://doi.org/10.1016/j.jad.2017.10.020.CrossRefPubMed

38.

Kurella, M., Kimmel, P. L., Young, B. S., & Chertow, G. M. (2005). Suicide in the United States end-stage renal disease program. Journal of the American Society of Nephrology,16(3), 774–781. https://doi.org/10.1681/ASN.2004070550.CrossRefPubMed

39.

Davison, S. N., & Jassal, S. V. (2016). Supportive care: Integration of patient-centered kidney care to manage symptoms and geriatric syndromes. Clinical Journal of the American Society of Nephrology,11(10), 1882–1891. https://doi.org/10.2215/CJN.01050116.CrossRefPubMedPubMedCentral

40.

Foote, C., Morton, R. L., Jardine, M., Gallagher, M., Brown, M., Howard, K., et al. (2014). COnsiderations of nephrologists when suggesting dialysis in elderly patients with renal failure (CONSIDER): A discrete choice experiment. Nephrology Dialysis Transplantation,29(12), 2302–2309. https://doi.org/10.1093/ndt/gfu257.CrossRef

41.

Netuveli, G., Pikhart, H., Bobak, M., & Blane, D. (2012). Generic quality of life predicts all-cause mortality in the short term: evidence from British Household Panel Survey. Journal of Epidemiology and Community Health,66(10), 962–966. https://doi.org/10.1136/jech-2011-200310.CrossRefPubMed

42.

Almeida, O. P., Alfonso, H., Hankey, G. J., & Flicker, L. (2010). Depression, antidepressant use and mortality in later life: The health in men study. PLoS ONE,5(6), 1–10. https://doi.org/10.1371/journal.pone.0011266.CrossRef

Title: Quality of life may be a more valuable prognostic factor than depression in older hemodialysis patients
Authors: Saulo Barbosa Vasconcelos de Alencar
Luana do Amaral Dias
Victor do Amaral Dias
Fábia Maria de Lima
Ulisses Ramos Montarroyos
Kátia Cristina Lima de Petribú
Publication date: 15-02-2020
Publisher: Springer International Publishing
Published in: Quality of Life Research / Issue 7/2020
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-020-02445-1

Springer Professional

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Wirtschaft"

Other articles of this Issue 7/2020

Psychometric characteristics of the WHOQOL-SRPB Scale in a population of stroke survivors and caregivers

Changes in quality of life and sleep across the perinatal period in women with mood disorders

Assessing the construct validity and responsiveness of Preference-Based Measures (PBMs) in cataract surgery patients

Self-esteem in patients with inflammatory bowel disease

Predictors of health-related quality of life among military HIV-infected individuals

Socioeconomic burden and quality of life in meningioma patients