17. Quantifying In-Host Patterns

This chapter is somewhat tangential to the main text but it does loosely loop back to the discussion in Sect. 1.2 on how patterns of in-host persistence are important determinants of population-level dynamics. In-host dynamics results from replication rates of pathogens as molded by the innate and adaptive branches of the host immune system. For example, using the TSIR as a tool for understanding plasmodium replication rates, Metcalf et al. (2011b, see also Sect. 8.9) documented a strong dose-response effect whereby the innate branch seemingly is able to slow the growth from low inocula but not subsequent anemia in the infected mice. Kamiya et al. (2020) provide further discussion of such dose-response effects and consequences for onwards transmission.