Skip to main content
Top

Hint

Swipe to navigate through the articles of this issue

Published in: Journal of Nanoparticle Research 6/2022

01-06-2022 | Review

Receptor-mediated cascade targeting strategies for the application to medical diagnoses and therapeutics of glioma

Authors: Man Liang, Juan Li, Leiqiang Han

Published in: Journal of Nanoparticle Research | Issue 6/2022

Login to get access
share
SHARE

Abstract

Glioma is the most frequent tumor of the central nervous system with high morbidity and mortality. Despite the great progress to exploit diagnostic and therapeutic tools, the treatment of glioma remains a huge challenge. The special anatomical structure of the brain, in particular, the blood–brain barrier (BBB) and the blood–brain tumor barrier (BBTB), limits the drug delivery efficacy and causes the diagnosis and treatment failure of various drugs. This encourages researchers to develop some novel therapeutic strategies to address these problems. Currently, receptor-mediated cascade targeting (RMCT) strategies, with targeting ligands targeting BBB and BBTB simultaneously, have been developed to overcome the barriers and are expected to accurately deliver drugs to glioma for diagnosis and therapy. In this review, we summarize the receptors and targeting ligands used in glioma, the categories of RMCT strategies, and the nanoplatforms used in RMCT strategies. We believe that the RMCT strategies will provide a reference for glioma treatment in the clinic and improve the life quality of patients with glioma.

To get access to this content you need the following product:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 69.000 Bücher
  • über 500 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt 90 Tage mit der neuen Mini-Lizenz testen!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 50.000 Bücher
  • über 380 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe



 


Jetzt 90 Tage mit der neuen Mini-Lizenz testen!

Literature
go back to reference Xie YD, Han YH, Zhang XF, Ma HW, Li LF, Yu RT, et al. (2021) Application of new radiosensitizer based on nano-biotechnology in the treatment of glioma. Front Oncol 11. Artn 63382710.3389/Fonc.2021.633827 Xie YD, Han YH, Zhang XF, Ma HW, Li LF, Yu RT, et al. (2021) Application of new radiosensitizer based on nano-biotechnology in the treatment of glioma. Front Oncol 11. Artn 63382710.3389/Fonc.2021.633827
Metadata
Title
Receptor-mediated cascade targeting strategies for the application to medical diagnoses and therapeutics of glioma
Authors
Man Liang
Juan Li
Leiqiang Han
Publication date
01-06-2022
Publisher
Springer Netherlands
Published in
Journal of Nanoparticle Research / Issue 6/2022
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-022-05482-8

Other articles of this Issue 6/2022

Journal of Nanoparticle Research 6/2022 Go to the issue

Premium Partners