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Quality of Life Research

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19-08-2017

Sample size determination for EQ-5D-5L value set studies

Authors: Mihir Gandhi, Ying Xu, Nan Luo, Yin Bun Cheung

Published in: Quality of Life Research | Issue 12/2017

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Abstract

Purpose

The EuroQol 5-Dimension (EQ-5D) is a widely used health status instrument for cost-utility analysis of healthcare interventions. Recently, its 5-Level version (EQ-5D-5L) and a protocol for conducting valuation of its health states were developed. We propose four approaches for estimating the sample size for EQ-5D-5L valuation according to the standardized procedures of the protocol.

Methods

The first approach is for estimating mean health state utility values with a desired precision level using a regression model. The second approach, empirical in nature, determines a sample size based on mean absolute error in predicting health state values using a large-scale reference study. The last two approaches are for assessing the significance of regression coefficients of health state descriptors and to estimate the regression coefficients with a desired precision for predicting health state utility values.

Results

Using data from a Singaporean study, we estimated parameters that are useful for sample size determination, including the design effect. Each of the approaches was illustrated with examples and pragmatic recommendations were provided.

Conclusions

Capitalizing on the EQ-5D-5L valuation protocol, we proposed four sample size estimation approaches which can help to decide an appropriate sample size for a value set study.

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Title: Sample size determination for EQ-5D-5L value set studies
Authors: Mihir Gandhi
Ying Xu
Nan Luo
Yin Bun Cheung
Publication date: 19-08-2017
Publisher: Springer International Publishing
Published in: Quality of Life Research / Issue 12/2017
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-017-1685-3

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Abstract

Purpose

Methods

Results

Conclusions

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