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26-01-2022 | Research Article

Selective corticocortical connectivity suppression during propofol-induced anesthesia in healthy volunteers

Authors: Haidong Wang, Yun Zhang, Huanhuan Cheng, Fei Yan, Dawei Song, Qiang Wang, Suping Cai, Yubo Wang, Liyu Huang

Published in: Cognitive Neurodynamics | Issue 5/2022

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Abstract

We comprehensively studied directional feedback and feedforward connectivity to explore potential connectivity changes that underlie propofol-induced deep sedation. We further investigated the corticocortical connectivity patterns within and between hemispheres. Sixty-channel electroencephalographic data were collected from 19 healthy volunteers in a resting wakefulness state and propofol-induced deep unconsciousness state defined by a bispectral index value of 40. A source analysis was employed to locate cortical activity. The Desikan-Killiany atlas was used to partition cortices, and directional functional connectivity was assessed by normalized symbolic transfer entropy between higher-order (prefrontal and frontal) and lower-order (auditory, sensorimotor and visual) cortices and between hot-spot frontal and parietal cortices. We found that propofol significantly suppressed feedforward connectivity from the left parietal to right frontal cortex and bidirectional connectivity between the left frontal and left parietal cortex, between the frontal and auditory cortex, and between the frontal and sensorimotor cortex. However, there were no significant changes in either feedforward or feedback connectivity between the prefrontal and all the lower-order cortices and between the frontal and visual cortices or in feedback connectivity from the frontal to parietal cortex. Propofol anesthetic selectively decreased the unidirectional interaction between higher-order frontoparietal cortices and bidirectional interactions between the higher-order frontal cortex and lower-order auditory and sensorimotor cortices, which indicated that both feedback and feedforward connectivity were suppressed under propofol-induced deep sedation. Our findings provide critical insights into the connectivity changes underlying the top-down mechanism of propofol anesthesia at deep sedation.

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Appendix
Available only for authorised users
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Metadata
Title
Selective corticocortical connectivity suppression during propofol-induced anesthesia in healthy volunteers
Authors
Haidong Wang
Yun Zhang
Huanhuan Cheng
Fei Yan
Dawei Song
Qiang Wang
Suping Cai
Yubo Wang
Liyu Huang
Publication date
26-01-2022
Publisher
Springer Netherlands
Published in
Cognitive Neurodynamics / Issue 5/2022
Print ISSN: 1871-4080
Electronic ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-021-09775-x

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