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03-11-2017 | Original Paper

Self-healing and injectable polysaccharide hydrogels with tunable mechanical properties

Authors: Hongchen Liu, Chaojing Li, Bijia Wang, Xiaofeng Sui, Lu Wang, Xiaolin Yan, Hong Xu, Linping Zhang, Yi Zhong, Zhiping Mao

Published in: Cellulose | Issue 1/2018

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Abstract

An injectable polysaccharide hydrogel based on cellulose acetoacetate (CAA), hydroxypropyl chitosan (HPCS), and amino-modified cellulose nanocrystals (CNC-NH₂) was prepared under physiological conditions. CNC-NH₂ acted as both physical and chemical cross-linker. The effects of CNC-NH₂ loading on the mechanical properties, internal morphology and gelation time were investigated; the maximum storage modulus was observed for a gel containing 0.80 wt% of CNC-NH₂. The structure and properties of the polysaccharide hydrogel were characterized by Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, scanning electron microscopy, Raman spectroscopy and rheology testing. The polysaccharide hydrogel exhibited pH- responsive properties and excellent stability under physiological conditions. The hydrogel also exhibited self-healing behavior under acidic conditions via enamine bond exchange. In addition, CCK-8 cytotoxicity study with fibroblast L929 cells demonstrates good biocompatibility of CNCs reinforced hydrogels.

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Title: Self-healing and injectable polysaccharide hydrogels with tunable mechanical properties
Authors: Hongchen Liu
Chaojing Li
Bijia Wang
Xiaofeng Sui
Lu Wang
Xiaolin Yan
Hong Xu
Linping Zhang
Yi Zhong
Zhiping Mao
Publication date: 03-11-2017
Publisher: Springer Netherlands
Published in: Cellulose / Issue 1/2018
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-017-1546-9

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