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Published in:
15-03-2018
Simulation analysis of the pathogenesis of Parkinson’s disease based on multiple factors leading to mitochondrial damage
Published in: Cluster Computing | Special Issue 2/2019
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Abstract
Parkinson’s disease (PD) is a neurodegenerative disease seriously threatening the elderly. Recent studies have shown that autophagy plays a key role in the clearance of organelles associated with neurodegenerative diseases, and plays an important role in the development and progression of PD; however, its mechanism is not yet clear. In this study, the model of aging mice was used to establish PD model by intra peritoneal injection of MPTP to study the effect of aging changes of autophagy on the mechanism of MPTP toxicity mechanism and its relationship with mitochondrial function and mitochondrial dynamics; and at the same time, young mice were selected to carry out moderate-intensity treadmill training, after 6 weeks, the PD model was established to explore the effect of exercise pre-training on the above indexes of PD mice, and explore the relationship between autophagy and PD, autophagy and mitochondrial dynamics and mitochondrial function.