Simulation of Variation of Intraocular Pressure

The movement of the eyes, in the left–right direction causes changes in the curvature of their corneas. This change of curvature causes a transient state of the intraocular pressure due to variations in the capacity of ocular chambers. This is the physical process of forced convection, so there is the transport of nutrients and elimination of metabolic secretions. Understandably, the failure of the process of forced convection can cause the retention of metabolic secretions that can be eliminated after a long time and may result in concentrations of excessive metabolic secretions causing contamination of the aqueous humor in the anterior chamber. This excessive metabolic mass in the anterior chamber can obstruct the trabecular meshwork, as a result increasing the output resistance of the aqueous stream and increasing the intraocular pressure. A simulator was developed to demonstrate the existence of this transient state of intraocular pressure and shows that reducing the formation of aqueous humor reduces intraocular pressure. However, simulations also showed the existence of adverse conditions in which the intraocular pressure has a high peak pressure, depending on the conditions of the eye and of the personal habits of the individual, can develop into normal-tension glaucoma (also called low-tension glaucoma). Therefore this study provides suggestions for preventing the normal-tension glaucoma a long time before the onset of symptoms.