Spatial Distribution as Additional Parameter in Histochemical Quantification of Cell Changes Explored by an Image Analysing System

Both Golgi apparatus and lysosomes are associated with turnover of cell compartments and extracellular processes. The role of the microtubules maintaining the location of Golgi vesicles as well as the intracellular transport of lysosomes is demonstrated in many experiments dealing with microtubule poisons. Due to the sensitivity of the microtubule system to chemicals, a direct correlation between the spatial distribution of the lysosomal apparatus and the biochemical condition of the cell can be assumed.