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Published in: Journal of Nanoparticle Research 4/2013

01-04-2013 | Research Paper

Spherical agglomerates of pure drug nanoparticles for improved pulmonary delivery in dry powder inhalers

Authors: Jun Hu, Yuancai Dong, Giorgia Pastorin, Wai Kiong Ng, Reginald B. H. Tan

Published in: Journal of Nanoparticle Research | Issue 4/2013

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Abstract

The aim of this study was to produce micron-sized spherical agglomerates of pure drug nanoparticles to achieve improved aerosol performance in dry powder inhalers (DPIs). Sodium cromoglicate was chosen as the model drug. Pure drug nanoparticles were prepared through a bottom-up particle formation process, liquid antisolvent precipitation, and then rapidly agglomerated into porous spherical microparticles by immediate (on-line) spray drying. Nonporous spherical drug microparticles with similar geometric size distribution were prepared by conventional spray drying of the aqueous drug solution, which together with the mechanically micronized drug particles were used as the control samples. The three samples were characterized by field emission scanning electron microscopy, laser diffraction, Brunauer–Emmett–Teller analysis, density measurement, powder X-ray diffraction, and in vitro aerosol deposition measurement with a multistage liquid impinger. It was found that drug nanoparticles with a diameter of ~100 nm were precipitated and agglomerated into highly porous spherical microparticles with a volume median diameter (D 50 %) of 2.25 ± 0.08 μm and a specific surface area of 158.63 ± 3.27 m2/g. In vitro aerosol deposition studies showed the fine particle fraction of such spherical agglomerates of drug nanoparticles was increased by more than 50 % in comparison with the control samples, demonstrating significant improvements in aerosol performance. The results of this study indicated the potential of the combined particle engineering process of liquid antisolvent precipitation followed by immediate (on-line) spray drying in the development of novel DPI drug products with improved aerosol performance.

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Metadata
Title
Spherical agglomerates of pure drug nanoparticles for improved pulmonary delivery in dry powder inhalers
Authors
Jun Hu
Yuancai Dong
Giorgia Pastorin
Wai Kiong Ng
Reginald B. H. Tan
Publication date
01-04-2013
Publisher
Springer Netherlands
Published in
Journal of Nanoparticle Research / Issue 4/2013
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-013-1560-2

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