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Journal of Polymer Research
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01-02-2025 | Original Paper

Synthesis and characterization of an injectable, self-healing hydrogel based on succinyl chitosan, oxidized pectin, and cellulose nanofiber for biomedical applications

Authors: Atefeh Afroozan Bazghaleh, Mojtaba Akbari Dogolsar, Roya Salehi, Jalal Barzin

Published in: Journal of Polymer Research | Issue 2/2025

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Abstract

In this research, we successfully synthesized an injectable, self-healing hydrogel based on succinyl chitosan (SC)/oxidized pectin (OP)/cellulose nanofibers (CNFs). This hydrogel was formed via the cooperative interaction of imine bonds, and hydrogen bonding, eliminating the necessity for a cross-linking agent. In all cases, the gelation occurred within seconds (< 60 s). The hydrogels demonstrated regeneration within a duration of 16 min, as determined by visual and rheological evaluations, without the need for any supplementary external stimuli. The elastic modulus of the SC/OP/CNF hydrogels was greater than that of the SC/OP hydrogel produced without CNF. Furthermore, SC/OP/CNF hydrogel showed excellent compatibility with blood (hemolysis rate < 3). Cytotoxicity studies, including MTT, and DAPI staining of hydrogels using human fibroblast cells (HFFF2) validated their good cytocompatibility. The results indicated that the prepared hydrogels could be used as injectable, self-healing hydrogel in biomedical contexts.
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Metadata
Title
Synthesis and characterization of an injectable, self-healing hydrogel based on succinyl chitosan, oxidized pectin, and cellulose nanofiber for biomedical applications
Authors
Atefeh Afroozan Bazghaleh
Mojtaba Akbari Dogolsar
Roya Salehi
Jalal Barzin
Publication date
01-02-2025
Publisher
Springer Netherlands
Published in
Journal of Polymer Research / Issue 2/2025
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-025-04283-6

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