Synthesis and Characterization of Biodegradable and Nontoxic Water Borne Copoly(Ether-Urethane-Urea)s Based on Amino Acid Derivatives

Biodegradable and biocompatible polyurethanes are a class of polymers that are useful in medical industry. In this study, new biodegradable and nontoxic water dispersed co-poly(ether-urethane-urea)s (PEUU)s were synthesized based on amino acid and peptide moiety. These polymers were prepared via the reaction of L-leucine anhydride cyclopeptid (LAC), polyethylene glycol (PEG), hexamethylene diisocyante (HDI) and serine (S) as dispersing agent. These polymers were characterized by FT-IR, NMR, TGA, DSC, AFM, and DLS. PEUU polymers were synthetized with three different structural architectures and block sequence. The polymer’s particle size dispersions are around 300 nm. The degradation test was carried out in PBS at 37 °C and evaluated by weight loss, viscosity and particle size decrement as well as by AFM. In order to determine cytotoxicity of the polymers, in vitro toxicity of final polymer was assessed using L929 mouse fibroblast cell line. The results showed no cytotoxicity of these polymers.