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Journal of Nanoparticle Research

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01-09-2018 | Research Paper

Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications

Authors: M. Toro-González, D. M. Clifford, R. Copping, S. Mirzadeh, J. V. Rojas

Published in: Journal of Nanoparticle Research | Issue 9/2018

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Abstract

Lanthanide phosphate nanomaterials are appealing as multifunctional platforms for biomedical applications because of their low toxicity, radiation resistance, and unique luminescence and magnetic properties. Lanthanide phosphate nanoparticles (NPs) radiolabeled with ¹⁵⁶Eu were synthesized by an aqueous route using sodium tripolyphosphate as a phosphate source and complexing agent. GdPO₄ was used as a host matrix, while synthetic concentrations of Ce³⁺/Tb³⁺ and Eu³⁺ were varied between 5–40% and 10–30%, respectively, and yielded spherical NPs with hexagonal crystal system and particle size < 5 nm. Luminescence emission and magnetic susceptibility were influenced by lanthanide concentrations where characteristic ⁵D₀-⁷F_J and ⁵D₄-⁷F_J transitions were observed for Eu³⁺- and Tb³⁺-doped NPs, respectively. Chemical yield of > 90% was achieved for GdPO₄ and Gd_0.6Ce_0.3Tb_0.1PO₄ NPs intrinsically radiolabeled with ¹⁵⁶Eu. In vitro retention of ¹⁵⁶Eu within LnPO₄ NPs was > 97% over 3 weeks. Intrinsically radiolabeled LnPO₄ NPs have the potential to combine the luminescence and magnetic properties of Ln³⁺ ions with lanthanide radioisotopes for biomedical and environmental applications.

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Title: Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications
Authors: M. Toro-González
D. M. Clifford
R. Copping
S. Mirzadeh
J. V. Rojas
Publication date: 01-09-2018
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 9/2018
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-018-4338-8

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