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Published in: Journal of Nanoparticle Research 9/2018

01-09-2018 | Research Paper

Synthesis and characterization of PVP-coated tellurium nanorods and their antibacterial and anticancer properties

Authors: Christopher D. Brown, David M. Cruz, Amit K. Roy, Thomas J. Webster

Published in: Journal of Nanoparticle Research | Issue 9/2018

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Abstract

Antibiotic resistance is a predicament that affects more than 2 million people worldwide each year. Through the over-prescription and extensive use of antibiotics, bacteria have generated resistance to many common antibiotic treatments. A promising approach to target antibiotic-resistant bacteria is the use of metallic nanoparticles. In this work, an environmentally safe synthesis of tellurium nanoparticles was explored. Rod-shaped tellurium nanoparticles coated with polyvinylpyrrolidone (PVP) were prepared using a facile hydrothermal reduction reaction. Transmission electron microscopy (TEM) images were used to characterize the size and morphology of the nanoparticles and showed a narrow size distribution. In addition, energy dispersive X-ray spectroscopy (EDS) was performed to verify the chemical composition of the nanoparticles. Antibacterial assays determined that treatment with nanoparticles at concentrations of 25 to 100 μg/mL induced a decay in the growth of both Gram-negative and Gram-positive bacteria—both antibiotic-resistant and non-antibiotic-resistance strains. To determine the effects of the nanoparticles on off-target cells, cytotoxicity assays were performed using human dermal fibroblasts (HDF) and melanoma (skin cancer) cells for durations of 24 and 48 h. Treatment with nanoparticles at concentrations between 10 and 100 μg/mL showed no significant cytotoxicity towards HDF cells. Contrarily, in melanoma cells, a cytotoxic effect was observed at the same concentrations. This suggests that the nanoparticles possess both anticancer properties towards melanoma cells and antibacterial effects without being toxic to healthy cells. These properties show that, for the first time, PVP-coated tellurium nanorods can be exploited for the treatment of antibiotic-resistant bacterial infections. These nanorods should be further explored for numerous antibacterial and anticancer applications.
Literature
go back to reference Cao H (2017) Silver nanoparticles for antibacterial devices: biocompatibility and toxicity. CRC Press Cao H (2017) Silver nanoparticles for antibacterial devices: biocompatibility and toxicity. CRC Press
go back to reference Li M, Zhu L, Lin D (2011) Toxicity of ZnO nanoparticles to Escherichia coli: mechanism and the influence of medium components. Environmental Science Tech 45(5):1977–1983 CrossRef Li M, Zhu L, Lin D (2011) Toxicity of ZnO nanoparticles to Escherichia coli: mechanism and the influence of medium components. Environmental Science Tech 45(5):1977–1983 CrossRef
go back to reference Medina Cruz D, Mi G, Webster TJ (2018) Synthesis and characterization of biogenic selenium nanoparticles with antimicrobial properties made by staphylococcus aureus, methicillin-resistant staphylococcus aureus (MRSA), ESCHERICHIA coli and Pseudomonas aeruginosa. J Biomed Mater Res A 106:1400–1412 CrossRef Medina Cruz D, Mi G, Webster TJ (2018) Synthesis and characterization of biogenic selenium nanoparticles with antimicrobial properties made by staphylococcus aureus, methicillin-resistant staphylococcus aureus (MRSA), ESCHERICHIA coli and Pseudomonas aeruginosa. J Biomed Mater Res A 106:1400–1412 CrossRef
go back to reference Ventola CL (2015) The antibiotic resistance crisis: part 1: causes and threats. Pharmacy and Therapeutics 40(4):277–283 Ventola CL (2015) The antibiotic resistance crisis: part 1: causes and threats. Pharmacy and Therapeutics 40(4):277–283
go back to reference Yu Q, Li J, Zhang Y, Wang Y, Liu L, Li M (2016) Inhibition of gold nanoparticles (AuNPs) on pathogenic biofilm formation and invasion to host cells. Sci Rep 6:26667 CrossRef Yu Q, Li J, Zhang Y, Wang Y, Liu L, Li M (2016) Inhibition of gold nanoparticles (AuNPs) on pathogenic biofilm formation and invasion to host cells. Sci Rep 6:26667 CrossRef
Metadata
Title
Synthesis and characterization of PVP-coated tellurium nanorods and their antibacterial and anticancer properties
Authors
Christopher D. Brown
David M. Cruz
Amit K. Roy
Thomas J. Webster
Publication date
01-09-2018
Publisher
Springer Netherlands
Published in
Journal of Nanoparticle Research / Issue 9/2018
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-018-4354-8

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