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2014 | OriginalPaper | Chapter

73. Synthesis of 1,3-benzodioxol-5-ethanol and Its Derivatives

Authors : Na Ji, Yinghao Gao, Yuanmou Chen, Shaolong Jia, Fei Hu, Peng Yu, Erbing Hua

Published in: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Publisher: Springer Berlin Heidelberg

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Abstract

It has been reported that resveratrol can enhance Sirt1 expression and has the activation effect on the proteins related to insulin signaling. It can also ameliorate insulin tolerance in order to achieve the function of preventing and curing diabetes. In this work, we designed a new series of analogs related to the structure of resveratrol such as 1,3-benzodioxol-5-ethanol, which is synthesized from 1,3-benzodioxole by the reactions of Friedel-Crafts reaction, Wolff-Kishner-Huang and reduction. In addition, seven new 1,3-benzodioxol-5-ethanol derivatives were obtained through esterification with different substituents of organic acid. All compounds were characterized by ¹H-NMR. Yields of derivatives are from 13.2 to 78.8 %.

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Title: Synthesis of 1,3-benzodioxol-5-ethanol and Its Derivatives
Authors: Na Ji
Yinghao Gao
Yuanmou Chen
Shaolong Jia
Fei Hu
Peng Yu
Erbing Hua
Publisher: Springer Berlin Heidelberg
Book: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)
Print ISBN: 978-3-642-37921-5

Electronic ISBN: 978-3-642-37922-2

Copyright Year: 2014
DOI: https://doi.org/10.1007/978-3-642-37922-2_73

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