Top

Journal of Nanoparticle Research

Hint

Swipe to navigate through the articles of this issue

Published in:

01-03-2015 | Research Paper

Synthesis of 5-Fluorouracil conjugated LaF₃:Tb³⁺/PEG-COOH nanoparticles and its studies on the interaction with bovine serum albumin: spectroscopic approach

Authors: Rajendiran Mangaiyarkarasi, Shanmugavel Chinnathambi, Prakasarao Aruna, Singaravelu Ganesan

Published in: Journal of Nanoparticle Research | Issue 3/2015

Abstract

The luminescent lanthanide-doped nanoparticles have gathered considerable attention in many fields especially in biomedicine. In this work, the lanthanum fluoride-doped terbium nanoparticles (LaF₃:Tb³⁺ NPs) via simple chemical precipitation method has been synthesized and functionalized with polyethylene glycol. The size and the shape of the nanoparticles are confirmed using X-ray diffraction and transmission electron microscopy. The conjugation of 5-Fluorouracil (5-FU) and thus synthesized nanoparticles (NPs) were confirmed using various spectroscopic methods such as UV–Visible spectroscopy, fluorescence steady state, and excited state spectroscopy studies. The enhancement in fluorescence emission (λ = 543 nm) of drug-conjugated nanoparticles confirms the Vander Waals force of attraction due to F–F bonding between the drug and the nanoparticles. Further, the effects of 5FU-NPs in carrier protein were investigated using bovine serum albumin as a protein model. The 5FU–LaF₃:Tb³⁺ nanoparticles binding is illustrated with binding constant and number of binding sites. The structural change of bovine serum albumin has been studied using circular dichroism and Fourier transform infrared spectroscopy analysis.

Graphical Abstract

previous article Tailoring the chemical composition and dispersion behavior of fluorinated graphene oxide via CF4 plasma

next article Differential contrast of gold nanorods in dual-band OCT using spectral multiplexing

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Abdi K, Nafisi Sh, Manouchehri F, Bonsaii M, Khalaj A (2012) Interaction of 5-Fluorouracil and its derivatives with bovine serum albumin. J Photochem Photobiol 107:20–26. doi: 10.1016/j.jphotobiol.2011.11.004 CrossRef

Amir M, Seyed AS, Ebrahim VF (2008) 5-Fluorouracil-loaded BSA nanoparticles: formulation optimization and in vitro release study. AAPS Pharm SciTech 9(4):1092–1096. doi: 10.1208/s12249-008-9146-5 CrossRef

Ansari AA, Singh N, Singh SP (2008) Optical properties of pyridine functionalized TbF ₃ nanoparticles. J Nanopart Res 10(4):703–707. doi: 10.1007/s11051-007-9297-4 CrossRef

Bakkialakshmi S, Chandrakala D (2011) A study on the interaction of 5-Fluorouracil with human serum albumin using fluorescence quenching method. J Pharm Sci Res 3(7):1326–1329

Barbero N, Barni E, Barolo C, Quagliotto P, Viscardi G, Napione l, Pavan S, Bussolino F (2009) A study of the interaction between fluorescein sodium salt and bovine serum albumin by steady-state fluorescence. Dyes Pigments 80:307–313. doi: 10.1016/j.dyepig.2008.08.006 CrossRef

Bardhan R, Grady NK, Cole JR, Joshi A, Halas NJ (2009) Fluorescence enhancement by Au nanostructures: nanoshells and nanorods. ACS Nano 3(3):744–752. doi: 10.1021/nn900001q CrossRef

Bi S, Sun Y, Qiao C, Zhang H, Liu C (2009) Binding of several anti-tumor drugs to bovine serum albumin: Fluorescence study. J Lumin 129(5):541–547. doi: 10.1016/j.jlumin.2008.12.010 CrossRef

Carlo B, Giorgio A, Gloria UB, Lorenzo DB, Piero S (1995) The binding of 5-Fluorouracil to native and modified human serum albumin: UV, CD, and 1H and 19F NMR investigation. J Pharm Biomed Anal 13:1087–1093 CrossRef

Chai R, Lian H, Yang P, Fan Y, Hou Z, Kang X, Liu J (2009) In situ preparation and luminescent properties of LaPO ₄:Ce ³⁺, Tb ³⁺nanoparticles and transparent LaPO ₄:Ce ³⁺, Tb ³⁺/PMMA nanocomposites. J Colloid Interface Sci 336:46–50. doi: 10.1016/j.jcis.2009.03.079 CrossRef

Chander H, Chawla S (2008) Time resolved spectroscopic studies on some nanophosphors. Bull Mater Sci 31(3):401–407 CrossRef

Chaudhary A, Gupta A, Khan S, Nandi CK (2014) Morphological effect of gold nanoparticles on the adsorption of bovine serum albumin. Phys Chem Chem Phys 16:20471–20482. doi: 10.1039/c4cp01515k CrossRef

Chinnathambi S, Velmurugan D, Hanagata N, Aruna P, Ganesan S (2014) Investigations on the interactions of 5-Fluorouracil with bovine serum albumin: optical spectroscopic and molecular modelling studies. J Lumin 151:1–10. doi: 10.1016/j.jlumin.2014.01.063 CrossRef

Dai Q, Wang Y, Li X, Zhang Y, Pellegrino DJ, Zhao M, Zou B, Seo JT, Wang Y, Yu W (2009) Size-dependent composition and molar extinction coefficient of PbSe semiconductor nanoparticles. ACS Nano 3(6):1518–1524. doi: 10.1021/nn9001616 CrossRef

Dai Y, Yang D, Ma P, Kang X, Zhan X, Li C, Hou Z, Cheng Z, Lin J (2012) Doxorubicin conjugated NaYF ₄:Yb ³⁺/Tm ³⁺ nanoparticles for therapy and sensing of drug delivery by luminescence resonance energy transfer. Biomaterials 33:8704–8713. doi: 10.1016/j.biomaterials.2012.08.029 CrossRef

Gao D, Zhang X, Zhang J (2014) The effects of structural characterization on the luminescence of Eu3 ⁺-doped fluoride nano/microcrystals. Cryst Eng Commun 16:11115–11121 CrossRef

Gaurkhede SG, Khandpekar MM, Pati SP, Singh AT (2013) Synthesis of hexagonal LaF ₃:ND ³⁺, SM ³⁺ nanocrystals and studies of NLO properties. Nanosystems 4(2):241–246

Gipson K, Kucera C, Stadther D, Stevens K, Ballato J, Brown P (2011) The influence of synthesis parameters on particle size and photoluminescence characteristics of ligand capped Tb ³⁺:LaF ₃. Polymers 3(4):2039–2052. doi: 10.3390/polym3042039 CrossRef

Gui R, Wan A, Jin H (2013) Facile synthesis of quantum dots/mesoporous silica/quantum dots core/shell/shell hybrid microspheres for ratiometric fluorescence detection of 5-Fluorouracil in human serum. Analyst 138:5956–5964. doi: 10.1039/c3an01089a CrossRef

Hanwen S, Yuanyuan W, Pan H, Yanli Z, Lv Yunkai (2012) Characterization of interaction between antitumor drug 5-Fluorouracil and human serum albumin by affinity capillary electrophoresis. Asian J Pharm Sci 7(1):75–79

Hao S, Chen G, Yang C (2013) Sensing using rare-earth-doped upconversion nano-particles. Theranostics 3(5):331–345. doi: 10.7150/thno.5305 CrossRef

Janib SM, Moses AS, Andrew JM (2010) Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev 62:1052–1063. doi: 10.1016/j.addr.2010.08.004 CrossRef

Jing K, Guo X, Diao X, Wu Q, Jiang Y, Sun Y, Pan X, Zhou N, Zhu Y (2015) Synthesis and characterization of dipicolinate sensitized LaF ₃:Tb ³⁺ nanoparticles and their interaction with bovine serum albumin. J Lumin 157:184–192. doi: 10.1016/j.jlumin.2014.08.061 CrossRef

Lakowicz JR (1999) Principles of fluorescence spectroscopy. Plenum Press, New York 278 CrossRef

Lekha NK, Sankar J, Asha NS, Vinod KGS (2011) Biological evaluation of 5-Fluorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGA. Int J Nanomed 6:1685–1697. doi: 10.2147/IJN.S20165

Li Y, He W, Liu J, Sheng F, Hu Z, Chen X (2005) Binding of the bioactive component jatrorrhizine to human serum albumin. Biochem Biophys Acta 1722:15–21. doi: 10.1016/j.bbagen.2004.11.006 CrossRef

Li C, Ma P, Yang P, Xu Z, Li G, Yang D, Penga C, Lin J (2011) Fine structural and morphological control of rare earth fluorides REF3 (RE ¼ La–Lu, Y) nano/microcrystals: microwave-assisted ionic liquid synthesis, magnetic and luminescent properties. Cryst Eng Commun 13:1003–1013. doi: 10.1039/c0ce00186d CrossRef

Liu Y, Chen W, Wang S, Joly AG, Westcott S, Woo BK (2008a) X-ray luminescence of LaF3:Tb3 ⁺ and LaF3:Ce3 ⁺, Tb3 ⁺ water-soluble nanoparticles. J Appl Phys 103(6):063105. doi: 10.1063/1.2890148 CrossRef

Liu Y, Chen W, Wang S, Joly AG (2008b) Investigation of water-soluble X-ray luminescence nanoparticles for photodynamic activation. Appl Phys Lett 92:043901. doi: 10.1063/1.2835701 CrossRef

Louis C, Bazzi R, Marquette CA, Bridot J, Roux S, Ledoux G, Mercier B, Blum L, Perriat P, Tillement O (2005) Nanosized hybrid particles with double luminescence for biological labeling. Chem Mater 17(7):1673–1682. doi: 10.1021/cm0480162 CrossRef

Mandal G, Bardhan M, Ganguly T (2010) Interaction of bovine serum albumin and albumin-gold nanoconjugates with l-aspartic acid. A spectroscopic approach. Colloid Surf B 81:178–184. doi: 10.1016/j.colsurfb.2010.07.002 CrossRef

Manna A, Chakravorti S (2013) Role of block copolymer-micelle nanocomposites in dye–bovine serum albumin binding: a combined experimental and molecular docking study. Mol Bio Syst 9:246–257. doi: 10.1039/C2MB25368B

Ming RC, Qing L, Tao W, Bing H, Jiang H, Hou XC, Feng XY, Wei W, Hong ZX, Tao Y, Bing BZ (2012) Galactosylated chitosan/5-Fluorouracil nanoparticles inhibit mouse hepatic cancer growth and its side effects. J Gastroenterol 18(42):6076–6087. doi: 10.3748/wjg.v18.i42.6076

Pramanik S, Banerjee P, Sarkar A, Bhattacharya SC (2008) Size-dependent interaction of gold nanoparticles with transport protein: a spectroscopic study. J Lumin 128:1969–1974. doi: 10.1016/j.jlumin.2008.06.008 CrossRef

Qiao J, Fabian M, Seema A (2011) Biocompatible drug delivery system for photo-triggered controlled release of 5-Fluorouracil. Biomacromolecules 12:3684–3691. doi: 10.1021/bm2009125 CrossRef

Seda AR, Mehlika P (2012) 5-Fluorouracil encapsulated chitosan nanoparticles for pH-stimulated drug delivery: evaluation of controlled release kinetics. J Nanomater 1–10:42. doi: 10.1155/2012/313961

Selvaraj V, Alagar M (2007) Analytical detection and biological assay of antileukemic drug 5-Fluorouracil using gold nanoparticles as probe. Int J Pharm 337:275–281. doi: 10.1016/j.ijpharm.2006.12.027 CrossRef

Song RQ, Colfen’k H (2010) Mesocrystals: ordered nanoparticle superstructures. Adv Mater 22(12):1301–1330. doi: 10.1002/adma.200901365 CrossRef

Stephanos JJ, Farina SA, Addison AW (1996) Iron ligand recognition by monomeric hemoglobins. Biochim Biophys Act 1295:209–221 CrossRef

Stoudam JW, Van Veggel FCJM (2002) Near-infrared emission of redispersible Er ³⁺, Nd ³⁺, and Ho ³⁺ doped LaF ₃ nanoparticles. Nano Lett 2:733–737. doi: 10.1021/nl025562q CrossRef

Sulkowska A, Rownicka J, Bojko B, Sulkowski W (2003) Interaction of anticancer drugs with human and bovine serum albumin. J Mol Struct 651:133–140 CrossRef

Wang L, Li P, Wang L (2009) Luminescent and hydrophilic LaF3-polymer nanocomposite for DNA detection. Luminescence 24:39–44. doi: 10.1002/bio.1061 CrossRef

Wang Q, You Y, Ludescher RD, Ju Y (2010) Syntheses of optically efficient (La1 _xyCe _xTb _y) F ₃ nanocrystals via a hydrothermal method. J Lumin 130:1076–1084. doi: 10.1016/j.jlumin.2010.01.028 CrossRef

Wang C, Cheng L, Liu Z (2013) Upconversion nanoparticles for photodynamic therapy and other cancer therapeutics. Theranostics 3(5):317–330. doi: 10.7150/thno.5284 CrossRef

Wangoo N, Suri CR, Shekhawat G (2008) Interaction of gold nanoparticles with protein: a spectroscopic study to monitor protein conformational changes. Appl Phys Lett 92:133104. doi: 10.1063/1.2902302 CrossRef

Xu H, Cheng L, Wang C, Ma X, Li Y, Liu Z (2011) Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery. Biomaterials 32:9364–9373. doi: 10.1016/j.biomaterials.2011.08.053 CrossRef

Yan J, Carmen EM, Smith JE, Wang K, Xiaoxiao H, Wang L, Tan W (2007) Dye doped nanoparticles for bioanalysis. Nano Today 2(3):44–50 CrossRef

Yan-Jun H, Yi L, Xue-Song S, Xian-Yang F, Song-Sheng Q (2005) Studies on the interaction between 1-hexylcarbamoyl-5-Fluorouracil and bovine serum albumin. J Mol Struct 738:143–147. doi: 10.1016/j.molstruc.2004.11.062 CrossRef

Yao M, Joly AG, Chen W (2010) Formation and luminescence phenomena of LaF ₃:Ce ³⁺ nanoparticles and lanthanide–organic compounds in dimethyl sulfoxide. J Phys Chem C 114:826–831. doi: 10.1021/jp9092173 CrossRef

Yassin AEB, Khalid AM, Mowafy HA, El-Bagory IM, Bayomi MA, Alsarra IA (2010) Optimization of 5-Fluorouracil solid–lipid nanoparticles: a preliminary study to treat colon cancer. Int J Med Sci 7:398–408 CrossRef

Zhang F, Braun GB, Alessia P, Yichi Z, Yifeng S, Daxiang C, Martin M, Dongyuan Z, Stucky GD (2012) Mesoporous multifunctional upconversion luminescent and magnetic “nanorattle” materials for targeted chemotherapy. Nano Lett 12:61–67. doi: 10.1021/nl202949y CrossRef

Title: Synthesis of 5-Fluorouracil conjugated LaF3:Tb3+/PEG-COOH nanoparticles and its studies on the interaction with bovine serum albumin: spectroscopic approach
Authors: Rajendiran Mangaiyarkarasi
Shanmugavel Chinnathambi
Prakasarao Aruna
Singaravelu Ganesan
Publication date: 01-03-2015
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 3/2015
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-015-2948-y

Springer Professional

Hint

Swipe to navigate through the articles of this issue

Abstract

Graphical Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Other articles of this Issue 3/2015

Effect of the nature of cationic precursors for SILAR deposition on the performance of CdS and PbS/CdS quantum dot-sensitized solar cells

Development, characterization, and in vitro evaluation of phosphatidylcholine–sodium cholate-based nanoparticles for siRNA delivery to MCF-7 human breast cancer cells

Combined bactericidal activity of silver nanoparticles and hexadecylpyridinium salicylate ionic liquid

Synthesis, photophysical analysis, and in vitro cytotoxicity assessment of the multifunctional (magnetic and luminescent) core@shell nanomaterial based on lanthanide-doped orthovanadates

Temperature dependence of the aggregation behavior of aluminum nanoparticles on liquid substrate

Growth of silver-coated gold nanoshells with enhanced linear and nonlinear optical responses

Premium Partners