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Arabian Journal for Science and Engineering
Published in: Arabian Journal for Science and Engineering 6/2020

22-04-2020 | Research Article-Chemistry

Synthesis, Structural and Biological Studies of Organotin(IV) Complexes with N-(Dithiocarboxy) Sarcosine

Authors: Shabbir Hussain, Saqib Ali, Saira Shahzadi, Muhammad Riaz, Khalida Nazir, Muhammad Nadeem Arshad, Abdullah M. Asiri

Published in: Arabian Journal for Science and Engineering | Issue 6/2020

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Abstract

Five organotin complexes with general formulae [LCSSSnR2]n (R = Me, n-Bu, Ph) and R3SnLCSSSnR3 (R = n-Bu, Ph) were synthesized by the reaction of equimolar quantities of sarcosine (HLH) with KOH, CS2 and either R2SnCl2 (R = Me, n-Bu, Ph) or R3SnCl (R = n-Bu, Ph) in methanol. Elemental (CHNS) analyses data and mass spectroscopy agreed well with the molecular composition of the synthesized products. FTIR spectroscopy verified the monodentate binding mode of the carboxylate group and a bidentate chelating behavior of the dithiocarboxylate moiety of the ligand for binding with tin(IV). Thus, penta- and hexa-coordinated environments around tin were observed in the solid state in di- and triorganotin complexes, respectively. The penta-coordinated geometry in diorganotin(IV) product 2 was further verified by its single-crystal XRD analysis. The organotin moieties and ligand units were interconnected with each other alternately in hexameric cyclic arrangement. The number of protons found in 1H NMR spectra was in good agreement with those calculated by incremental method. Complexes were examined for their antioxidant, antimicrobial, antidiabetic, thrombolytic, hemolytic activities. The free ligand HLH was found inactive against all the four bacterial strains.
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Metadata
Title
Synthesis, Structural and Biological Studies of Organotin(IV) Complexes with N-(Dithiocarboxy) Sarcosine
Authors
Shabbir Hussain
Saqib Ali
Saira Shahzadi
Muhammad Riaz
Khalida Nazir
Muhammad Nadeem Arshad
Abdullah M. Asiri
Publication date
22-04-2020
Publisher
Springer Berlin Heidelberg
Published in
Arabian Journal for Science and Engineering / Issue 6/2020
Print ISSN: 2193-567X
Electronic ISSN: 2191-4281
DOI
https://doi.org/10.1007/s13369-020-04496-5

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