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2012 | OriginalPaper | Chapter

The Cell–Surface Interaction

Authors : J. S. Hayes, E. M. Czekanska, R. G. Richards

Published in: Tissue Engineering III: Cell - Surface Interactions for Tissue Culture

Publisher: Springer Berlin Heidelberg

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Abstract

The realm of surface-dependent cell and tissue responses is the foundation of orthopaedic-device-related research. However, to design materials that elicit specific responses from tissues is a complex proposition mainly because the vast majority of the biological principles controlling the interaction of cells with implants remain largely ambiguous. Nevertheless, many surface properties, such as chemistry and topography, can be manipulated in an effort to selectively control the cell–material interaction. On the basis of this information there has been much research in this area, including studies focusing on the structure and composition of the implant interface, optimization of biological and chemical coatings and elucidation of the mechanisms involved in the subsequent cell–material interactions. Although a wealth of information has emerged, it also advocates the complexity and dynamism of the cell–material interaction. Therefore, this chapter aims to provide the reader with an introduction to the basic concepts of the cell–material interaction and to provide an insight into the factors involved in determining the cell and tissue response to specific surface features, with specific emphasis on surface microtopography.

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next chapter Studying Cell–Surface Interactions In Vitro: A Survey of Experimental Approaches and Techniques
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Metadata
Title
The Cell–Surface Interaction
Authors
J. S. Hayes
E. M. Czekanska
R. G. Richards
Copyright Year
2012
Publisher
Springer Berlin Heidelberg
Book
Tissue Engineering III: Cell - Surface Interactions for Tissue Culture

Print ISBN: 978-3-642-28281-2

Electronic ISBN: 978-3-642-28282-9

Copyright Year: 2012

DOI
https://doi.org/10.1007/10_2011_110

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