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Published in:
NS5A as a Target for HCV Drug Discovery Read chapter Read first chapter

2019 | OriginalPaper | Chapter

The Discovery of Ledipasvir (GS-5885): The Potent Once-Daily Oral HCV NS5A Inhibitor in the Single-Tablet Regimen Harvoni®

Author : John O. Link

Published in: HCV: The Journey from Discovery to a Cure

Publisher: Springer International Publishing

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Abstract

The advent of direct-acting antiviral agents (DAAs) has revolutionized the treatment and cure of chronic hepatitis C virus (HCV) infection. Herein is described the discovery of ledipasvir (LDV), an orally available HCV nonstructural protein 5A inhibitor with picomolar antiviral potency and a long pharmacokinetic half-life. The combination of LDV with the nonstructural protein 5B inhibitor sofosbuvir (SOF) is Harvoni® and represents the first approved single-tablet regimen for the treatment of HCV infection. This safe simple and efficacious regimen affords clinical trial cure rates over 95% and comparable effectiveness in real-world studies and has treatment durations as short as 8 weeks. The approval of Harvoni® heralded a new era for the treatment of HCV infection.

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previous chapter The Discovery and Development of Daclatasvir: An Inhibitor of the Hepatitis C Virus NS5A Replication Complex
next chapter The Discovery of Velpatasvir (GS-5816): The Potent Pan-Genotypic Once-Daily Oral HCV NS5A Inhibitor in the Single-Tablet Regimens Epclusa and Vosevi®
Footnotes
2
Volume I, HCV: The Journey from Discovery to a Cure.
 
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Metadata
Title
The Discovery of Ledipasvir (GS-5885): The Potent Once-Daily Oral HCV NS5A Inhibitor in the Single-Tablet Regimen Harvoni®
Author
John O. Link
Copyright Year
2019
Book
HCV: The Journey from Discovery to a Cure

Print ISBN: 978-3-030-28399-5

Electronic ISBN: 978-3-030-28400-8

Copyright Year: 2019

DOI
https://doi.org/10.1007/7355_2019_66