Skip to main content
Top

25-03-2024 | Research Article

The influence of hyperpolarization-activated cation current on conduction delay and failure of action potentials along axon related to abnormal functions

Authors: Menglei Lu, Huaguang Gu, Xinjing Zhang

Published in: Cognitive Neurodynamics

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Conduction delay and failure behaviors of action potentials with a high frequency along nerve fiber are related to the abnormal functions. For instance, upregulation of a hyperpolarization-activated cation current (Ih) is identified to reduce the conduction delay to recover the temporal encoding, and downregulation of the Ih current to enhance the conduction failure rate to ease the pain sensation, with the dynamic mechanisms remaining unclear. In the present paper, the dynamic mechanism is obtained in a chain network model with coupling strength (gc) and action potentials induced by periodic stimulations with a period (Ts). At first, as the action potentials exhibit a high frequency corresponding to a short Ts and the network has a small gc, i.e., a short and unrecovered afterpotential and a small coupling current, the conduction delay is reproduced. The conduction failure is reproduced for Ts shorter and gc smaller than those of the conduction delay, presenting a direct relationship between the two behaviors. Then, the conduction delay and failure are explained with the response time and current threshold of an action potential evoked from the unrecovered afterpotential. The prolonged response time for short Ts and small gc presents the cause for the conduction delay, and the enhanced threshold for shorter Ts and smaller gc presents the cause for the conduction failure. Furthermore, reduction of the delay and enhancement of the failure rate respectively induced by upregulation and downregulation of the Ih current are reproduced and explained. The positive Ih current induces Hopf bifurcation advanced and resting membrane potential elevated. Then, upregulation and downregulation of the Ih current induce the afterpotential elevated to shorten the response time and reduced to enhance the threshold, respectively. The results present nonlinear dynamics for the non-faithful conduction behaviors and dynamical mechanism for the modulation effect of the Ih current on the conduction delay and failure related to encoding and pain.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literature
Metadata
Title
The influence of hyperpolarization-activated cation current on conduction delay and failure of action potentials along axon related to abnormal functions
Authors
Menglei Lu
Huaguang Gu
Xinjing Zhang
Publication date
25-03-2024
Publisher
Springer Netherlands
Published in
Cognitive Neurodynamics
Print ISSN: 1871-4080
Electronic ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-024-10103-2