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Inheritance Analysis for Exserted Stigma Rate in Japonica Rice Read chapter Read first chapter

2015 | OriginalPaper | Chapter

68. The New Strategy of Breeding Cytidine Excessive Biosynthesis Mutants by pyr Operon Rearrangement of Bacillus amyloliquefaciens

Authors : Qing Wu, Huiyan Liu, Haitian Fang, Jianguo He, Xiaoguang He, Linan Yu

Published in: Advances in Applied Biotechnology

Publisher: Springer Berlin Heidelberg

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Abstract

Cytidine is a good antitumor and antiviral intermediate which can also be used as a healthy food ingredients. With the market for cytidine increasing, the large-scale production of cytidine by microbial fermentation method has become a major way to solve this problem. While improving cytidine production, the regulation of pyr operon is essential to the excessive synthesis cytidine. However, its transcriptional regulation mechanism is unclear. The passage summarizes the regulation of de novo pyrimidine nucleotide biosynthesis (pyr genes) and the metabolic regulation mechanism of cytidine synthesis in Bacillus amyloliquefaciens. This paper makes the regulation protein pyrR as the research object, presents a series of Bacillus amyloliquefaciens pyrimidine operon transcriptional regulatory rearrangement strategy, effects the transcriptional regulation on cytidine biosynthesis, and aims to provide a theoretical basis for cytidine yielding strain.

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Metadata
Title
The New Strategy of Breeding Cytidine Excessive Biosynthesis Mutants by pyr Operon Rearrangement of Bacillus amyloliquefaciens
Authors
Qing Wu
Huiyan Liu
Haitian Fang
Jianguo He
Xiaoguang He
Linan Yu
Copyright Year
2015
Publisher
Springer Berlin Heidelberg
Book
Advances in Applied Biotechnology

Print ISBN: 978-3-662-46317-8

Electronic ISBN: 978-3-662-46318-5

Copyright Year: 2015

DOI
https://doi.org/10.1007/978-3-662-46318-5_68

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