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2021 | OriginalPaper | Chapter

Therapeutic Angiogenesis in Regenerative Medicine

Authors : Veronica Sacchi, Rainer Mittermayr, Martin Ehrbar

Published in: Vascularization for Tissue Engineering and Regenerative Medicine

Publisher: Springer International Publishing

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Abstract

A vascular network along with a sufficient blood supply is not only essential for physiological maintenance of tissue viability but is also a prerequisite for any approaches in regenerative medicine. Previously it was thought that therapeutic angiogenesis can effectively be realized simply by the local release of angiogenic growth factors from matrices, but a more complex correlation between the spatial and temporal distribution of factors and the microenvironmental tissue demands has emerged. After introducing the different kinds and steps of angiogenesis, the review will highlight the key issues of therapeutic angiogenesis and various opportunities for recombinant growth factor delivery strategies. The modifications of binding and release kinetics of angiogenic factors from delivery platforms will be discussed in detail in order to achieve a mature and functional vascular network.

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Title: Therapeutic Angiogenesis in Regenerative Medicine
Authors: Veronica Sacchi
Rainer Mittermayr
Martin Ehrbar
Publisher: Springer International Publishing
Book: Vascularization for Tissue Engineering and Regenerative Medicine
Print ISBN: 978-3-319-54584-4

Electronic ISBN: 978-3-319-54586-8

Copyright Year: 2021
DOI: https://doi.org/10.1007/978-3-319-54586-8_6