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2018 | OriginalPaper | Chapter

54. Thermal Properties of Porcine and Human Biological Systems

Authors : Shaunak Phatak, Harishankar Natesan, Jeunghwan Choi, Robert Sweet, John Bischof

Published in: Handbook of Thermal Science and Engineering

Publisher: Springer International Publishing

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Abstract

For applications of bioheat transfer such as thermal therapies and cryopreservation, the temperature excursions experienced by a biomaterial can be directly correlated to the injuries that may occur in the system. Thermal modeling is an important tool in order to predict this temperature history as it is not always possible to experimentally measure the temperature and cooling/heating rates experienced by the biomaterials. These models make use of temperature-dependent thermal properties in order to accurately predict the thermal histories experienced by the systems. This review chapter focuses on listing literature data of human and porcine systems for thermal conductivity and specific heat capacity in the cryogenic, subzero, and suprazero temperature ranges. At subzero and cryogenic temperatures, thermal properties are affected by phase change (water to ice) and vitrification or glass formation in the presence of cryoprotectants, whereas water loss and protein denaturation are important factors at suprazero temperatures. Finally, a modeling case study is provided demonstrating the use and necessity of temperature-dependent properties in order to make accurate predictions for thermal history.

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Arkin H, Xu LX, Holmes KR (1994) Recent developments in modeling heat transfer in blood perfused tissues. IEEE Trans Biomed Eng 41:97–107. https://doi.org/10.1109/10.284920CrossRef

Baish J (2000) Microvascular heat transfer, Chapter 98-1. In: The biomedical engineering handbook. CRC Press, Boca Raton, FL USA

Balasubramaniam TA, Bowman HF (1977) Thermal conductivity and thermal diffusivity of biomaterials: a simultaneous measurement technique. J Biomech Eng 99:148. https://doi.org/10.1115/1.3426282CrossRef

Bald WB, Fraser J (1982) Cryogenic surgery. Reports Prog Phys 45:1381CrossRef

Baust JG, Gage AA (2005) The molecular basis of cryosurgery. BJU Int 95:1187–1191. https://doi.org/10.1111/j.1464-410X.2005.05502.xCrossRef

Belzer FO, Southard JH (1988) Principles of solid-organ preservation by cold storage. Transplantation 45:673–676CrossRef

Bhattacharya A, Mahajan RL (2003) Temperature dependence of thermal conductivity of biological tissues. Physiol Meas 24:769–783. https://doi.org/10.1088/0967-3334/24/3/312CrossRef

Bischof J, Han B (2002) Cryogenic heat and mass transfer in biomedical applications. Heat Transf 1:141–156

Bowman H (1981) Heat transfer and thermal dosimetry. J Microw Power Electromagn Energy 16:121–133

Bowman HF, Cravalho EG, Woods M (1975) Theory, measurement, and application of thermal properties of biomaterials. Annu Rev Biophys Bioeng 4:43–80. https://doi.org/10.1146/annurev.bb.04.060175.000355CrossRef

Cahill DG, Pohl RO (1987) Thermal conductivity of amorphous solids above the plateau. Phys Rev B 35:4067–4073. https://doi.org/10.1103/PhysRevB.35.4067CrossRef

Carpenter JF, Pikal MJ, Chang BS, Randolph TW (1997) Rational design of stable lyophilized protein formulations: some practical advice. Pharm Res 14:969–975. https://doi.org/10.1023/A:1012180707283CrossRef

Charny CK (1992) Mathematical models of bioheat transfer. Adv Heat Transf 22:19–155. https://doi.org/10.1016/S0065-2717(08)70344-7CrossRef

Chato JC (1968) A method for the measurement of the thermal properties of biological materials. In: American Society of Mechanical Engineers: symposium series: thermal problems in biotechnology. ASME, New York City, NY, USA

Chen MM, Holmes KR, Rupinskas V (1981) Pulse-decay method for measuring the thermal conductivity of living tissues. J Biomech Eng 103:253–260CrossRef

Cherneeva LI (1956) Study of thermal properties of foods. In: Report of Vnikhi. Scientific Research Institute of the Refrigeration Industry, Gostorgisdat

Choi JH, Bischof JC (2008) A quantitative analysis of the thermal properties of porcine liver with glycerol at subzero and cryogenic temperatures. Cryobiology 57:79–83. https://doi.org/10.1016/j.cryobiol.2008.05.004CrossRef

Choi J, Bischof JC (2010) Review of biomaterial thermal property measurements in the cryogenic regime and their use for prediction of equilibrium and non-equilibrium freezing applications in cryobiology. Cryobiology 60:52–70. https://doi.org/10.1016/j.cryobiol.2009.11.004CrossRef

Choi J, Morrissey M, Bischof JC (2013) Thermal processing of biological tissue at high temperatures: impact of protein denaturation and water loss on the thermal properties of human and porcine liver in the range 25–80 °C. J Heat Transf 135:61302. https://doi.org/10.1115/1.4023570CrossRef

Chu KF, Dupuy DE (2014) Thermal ablation of tumours: biological mechanisms and advances in therapy. Nat Rev Cancer 14:199–208. https://doi.org/10.1038/nrc3672CrossRef

Crowe JH, Hoekstra FA, Crowe LM (1992) Anhydrobiosis. Annu Rev Physiol 54:579–599. https://doi.org/10.1146/annurev.ph.54.030192.003051CrossRef

Diller KR (1992) Modeling of bioheat transfer processes at high and low temperatures. Adv Heat Transf 22:157–357. https://doi.org/10.1016/S0065-2717(08)70345-9CrossRef

Diller KR, Valvano JW, Pearce JA (2000) Bioheat transfer. CRC Handb Therm Eng 4:114–215

Duck FA (2013) Physical properties of tissues: a comprehensive reference book. Academic, London

Ehrlich LE, Feig JSG, Schiffres SN, Malen JA, Rabin Y (2015) Large thermal conductivity differences between the crystalline and vitrified states of DMSO with applications to cryopreservation. PLoS One 10:e0125862. doi:https://doi.org/10.1371/journal.pone.0125862CrossRef

Ehrlich LE, Malen JA, Rabin Y (2016) Thermal conductivity of the cryoprotective cocktail DP6 in cryogenic temperatures, in the presence and absence of synthetic ice modulators. Cryobiology 73:196–202. https://doi.org/10.1016/j.cryobiol.2016.07.012CrossRef

Etheridge ML, Choi J, Ramadhyani S, Bischof JC (2013) Methods for characterizing convective cryoprobe heat transfer in ultrasound gel phantoms. J Biomech Eng 135:21002. https://doi.org/10.1115/1.4023237CrossRef

Fahy GM, MacFarlane DR, Angell CA, Meryman HT (1984) Vitrification as an approach to cryopreservation. Cryobiology 21:407–426. https://doi.org/10.1016/0011-2240(84)90079-8CrossRef

Gage AA, Baust J (1998) Mechanisms of tissue injury in cryosurgery. Cryobiology 37:171–186. https://doi.org/10.1006/cryo.1998.2115CrossRef

Glassbrenner CJ, Slack GA (1964) Thermal conductivity of silicon and germanium from 3 °K to the melting point. Phys Rev 134:A1058–A1069. https://doi.org/10.1103/PhysRev.134.A1058CrossRef

Grayson J (1952) Internal calorimetry in the determination of thermal conductivity and blood flow. J Physiol 118:54–72CrossRef

Guntur SR, Lee K Il, Paeng D-G, Coleman AJ, Choi MJ (2013) Temperature-dependent thermal properties of ex vivo liver undergoing thermal ablation. Ultrasound Med Biol 39:1771–1784. https://doi.org/10.1016/j.ultrasmedbio.2013.04.014CrossRef

Hasgall PA, Di Gennaro F, Baumgartner C, Neufeld E, Gosselin MC, Payne D, Klingenböck A, Kuster N (2015) IT’IS Database for thermal and electromagnetic parameters of biological tissues. Version 3.0, 1 Sept 2015

He X, Bischof JC (2003) Quantification of temperature and injury response in thermal therapy and cryosurgery. Crit Rev Biomed Eng 31:355–422CrossRef

Henriques FC, Moritz AR (1947) Studies of thermal injury: I. The conduction of heat to and through skin and the temperatures attained therein. A theoretical and an experimental investigation. Am J Pathol 23:530–549

Hill JE, Leitman JD, Sunderland JE (1967) Thermal conductivity of various meats. Food Technol 21:1143

Hoffmann NE, Bischof JC (2002) The cryobiology of cryosurgical injury. Urology 60:40–49. https://doi.org/10.1016/S0090-4295(02)01683-7CrossRef

Höhne GWH, Hemminger W, Flammersheim H-J (1996) Differential scanning calorimetry. Springer, BerlinCrossRef

Karlsson JOM, Toner M (1996) Long-term storage of tissues by cryopreservation: critical issues. Biomaterials 17:243–256. https://doi.org/10.1016/0142-9612(96)85562-1CrossRef

Lentz CP (1961) Thermal conductivity of meats, fats, gelatin gels, and ice. Food Technol 15:243

Liu J, Zhu L, Xu LX (2000) Studies on the three-dimensional temperature transients in the canine prostate during transurethral microwave thermal therapy. J Biomech Eng 122:372. https://doi.org/10.1115/1.1288208CrossRef

Lubner SD, Choi J, Wehmeyer G, Waag B, Mishra V, Natesan H, Bischof JC, Dames C (2015) Reusable bi-directional 3ω sensor to measure thermal conductivity of 100-μm thick biological tissues. Rev Sci Instrum 86:14905. https://doi.org/10.1063/1.4905680CrossRef

Lewis JK, Bischof JC, Braslavsky I, Brockbank KGM, Fahy GM, Fuller BJ, Rabin Y, Tocchio A, Woods EJ, Wowk BG, Acker JP, Giwa S (2016) The grand challenges of organ banking: proceedings from the first global summit on complex tissue cryopreservation. Cryobiology 72:169–182CrossRef

Marcus SM, Reading M (1994) Method and apparatus for thermal conductivity measurements. US Patent 5,335,993

Mazur P (1984) Freezing of living cells: mechanisms and implications. Am J Physiol Cell Physiol 247(3):C125–C142CrossRef

Moline SW, Rinfret AP, Short AJ, Sawdye JA (1961) Thermal properties of foods at low temperatures. 1. Specific heat. Food Technol 15:228

Morley MJ (1966) Thermal conductivities of muscles, fats and bones. Int J Food Sci Technol 1:303–311CrossRef

Natesan H, Bischof JC (2016) Multi-scale thermal property measurements for biomedical applications. ACS Biomater Sci Eng ACS Biomater:6b00565. https://doi.org/10.1021/acsbiomaterials.6b00565

Natesan H, Choi J, Lubner S, Dames C, Bischof J (2016a) Multi-scale thermal conductivity measurements for cryobiological applications. In: Multiscale technologies for cryomedicine. World Scientific, Singapore, pp 125–171CrossRef

Natesan H, Hodges W, Choi J, Lubner S, Dames C, Bischof J (2016b) A micro-thermal sensor for focal therapy applications. Sci Rep 6:21395. https://doi.org/10.1038/srep21395CrossRef

O’Neal DP, Hirsch LR, Halas NJ, Payne JD, West JL (2004) Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett 209(2):171–176CrossRef

Ozisik N (1994) Finite difference methods in heat transfer. CRC Press, Boca Raton

Patel PA, Valvano JW, Pearce JA, Prahl SA, Denham CR (1987) A self-heated thermistor technique to measure effective thermal properties from the tissue surface. J Biomech Eng 109:330. https://doi.org/10.1115/1.3138689CrossRef

Pennes HH (1948) Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol 1:93–122CrossRef

Poppendiek HF, Randall R, Breeden JA, Chambers JE, Murphy JR (1967) Thermal conductivity measurements and predictions for biological fluids and tissues. Cryobiology 3:318–327. https://doi.org/10.1016/S0011-2240(67)80005-1CrossRef

Rabin Y, Shitzer A (1998) Numerical solution of the multidimensional freezing problem during cryosurgery. J Biomech Eng 120:32. https://doi.org/10.1115/1.2834304CrossRef

Rabin Y, Taylor MJ, Wolmark N (1998) Thermal expansion measurements of frozen biological tissues at cryogenic temperatures. J Biomech Eng 120:259. https://doi.org/10.1115/1.2798310CrossRef

Reading M, Hahn BK, Crowe BS (1993) Method and apparatus for modulated differential analysis. US Patent 5,224,775

Reading M, Luget A, Wilson R (1994) Modulated differential scanning calorimetry. Thermochim Acta 238:295–307. https://doi.org/10.1016/S0040-6031(94)85215-4CrossRef

Rossmann C, Haemmerich D (2014) Review of temperature dependence of thermal properties, dielectric properties, and perfusion of biological tissues at hyperthermic and ablation temperatures. Crit Rev Biomed Eng 42:467–492. https://doi.org/10.1615/CritRevBiomedEng.2015012486CrossRef

Rubinsky B (2000) Cryosurgery. Annu Rev Biomed Eng 2:157–187. https://doi.org/10.1146/annurev.bioeng.2.1.157CrossRef

Sabel MS (2009) Cryo-immunology: a review of the literature and proposed mechanisms for stimulatory versus suppressive immune responses. Cryobiology 58:1–11. https://doi.org/10.1016/j.cryobiol.2008.10.126CrossRef

Sapareto SA, Dewey WC (1984) Thermal dose determination in cancer therapy. Int J Radiat Oncol 10:787–800. https://doi.org/10.1016/0360-3016(84)90379-1CrossRef

Steponkus PL (1996) Advances in low-temperature biology, Vol 3. Elsevier, Amsterdam

Vachon RI, Walker FJ, Walker DF, Nix GH (1967) In vivo determination of thermal conductivity of bone using the thermal comparator technique. In: Digest of the Seventh International Conference of Medical and Biological Engineering. Stockholm

Valvano JW (1995) Tissue thermal properties and perfusion. In: Optical-thermal response of laser-irradiated tissue. Springer US, Boston, pp. 445–488CrossRef

Valvano JW, Cochran JR, Diller KR (1985) Thermal conductivity and diffusivity of biomaterials measured with self-heated thermistors. Int J Thermophys 6:301–311. https://doi.org/10.1007/BF00522151CrossRef

Vendrik AJH, Vos JJ (1957) A method for the measurement of the thermal conductivity of human skin. J Appl Physiol 11(2):211–215CrossRef

Yi F, Kim IK, Li S, Lavan DA (2014) Hydrated/dehydrated lipid phase transitions measured using nanocalorimetry. J Pharm Sci 103:3442–3447. https://doi.org/10.1002/jps.24187CrossRef

Yuan DY, Xu LX, Liang Zhu, Holmes KR, Valvano JW (1998) Perfusion and temperature measurements in hyperthermic canine prostates. In: Proceedings of the 17th Southern Biomedical Engineering Conference, pp 85–85

Zhang H, Cheng S, He L, Zhang A, Zheng Y, Gao D (2002) Determination of thermal conductivity of biomaterials in the temperature range 233–313K using a tiny detector made of a self-heated thermistor. Cell Preserv Technol 1:141–147. https://doi.org/10.1089/153834402320882647CrossRef

Zhang J, Sandison GA, Murthy JY, Xu LX (2005) Numerical simulation for heat transfer in prostate cancer cryosurgery. J Biomech Eng 127:279. https://doi.org/10.1115/1.1865193CrossRef

Title: Thermal Properties of Porcine and Human Biological Systems
Authors: Shaunak Phatak
Harishankar Natesan
Jeunghwan Choi
Robert Sweet
John Bischof
Publisher: Springer International Publishing
Book: Handbook of Thermal Science and Engineering
Print ISBN: 978-3-319-26694-7

Electronic ISBN: 978-3-319-26695-4

Copyright Year: 2018
DOI: https://doi.org/10.1007/978-3-319-26695-4_76

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