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01-02-2025

TiO₂ and PbTiO₃ assisted SPR biosensor for detection of malignancy in human-liver tissue with high sensitivity and figure of merit

Authors: Laxmi Jaiswal, Adarsh Chandra Mishra, Sapana Yadav, Pooja Lohia, D. K. Dwivedi, R. K. Yadav, Upendra Kulshrestha, Ammar M. Tighezza, M. Khalid Hossain

Published in: Journal of Computational Electronics | Issue 1/2025

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Abstract

A high performance Kretschmann configuration-based surface plasmons resonance (SPR) biosensor is proposed for the detection of hepatocellular carcinoma (HCC) liver tissues. The proposed structure consists of calcium fluoride (CaF₂) prism, silver (Ag) metal, and a heterojunction of titanium dioxide (TiO₂), lead titanate (PbTiO₃), and molybdenum di selenide (MoSe₂). Role of constituents materials is analyzed in terms of their contribution towards enhancement in the performance. At near infrared wavelength of 1000 nm, the thickness and number of layers of constituent layers is optimized in the light of practical realization. The proposed biosensor provides an ultrahigh sensitivity of 486 deg/RIU with a full-width half maximum (FWHM) of 1.0720 degrees and a figure of merits (FoM) of 453.35 RIU⁻¹. Further, the corresponding power-loss ratio is also calculated. Hence, the combined performance factor for the proposed sensor is 480.56 RIU⁻¹. The novelty of the work relies in the design and selection of material (especially TiO₂ and PbTiO₃) that offers the highest possible values of performance parameters for prism based sensor in the best of our knowledge.

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Tamada, K., Li, X., Wulandari, P., et al.: Fabrication and application of plasmonic silver nanosheet. Rev. Plasmonics 2010, 139–157 (2012)CrossRefMATH

Homola, J., Yee, S.S., Gauglitz, G.: Surface plasmon resonance sensors: review. Sens. Actuators B Chem. 54, 3–15 (1999). https://doi.org/10.1016/S0925-4005(98)00321-9CrossRef

Mudgal, N., Saharia, A., Agarwal, A., et al.: Modeling of highly sensitive surface plasmon resonance (SPR) sensor for urine glucose detection. Opt. Quantum Electron. (2020). https://doi.org/10.1007/s11082-020-02427-0CrossRefMATH

Homola, J., Yee, S.S., Gauglitz, G.: Surface plasmon resonance sensors: review. Sens. Actuators B Chem. 54, 3–15 (1999)CrossRef

Pal, A., Trabelsi, Y., Sarkar, P., et al.: Tuning sensitivity of surface plasmon resonance sensor based on ZnO layer and CaF₂ prism for the recognition of SARS-CoV-2. J. Mater. Sci.: Mater. Electron. (2024). https://doi.org/10.1007/s10854-024-13287-9CrossRefMATH

Abdulhalim, I., Zourob, M., Lakhtakia, A.: Surface plasmon resonance for biosensing: a mini-review. Electromagnetics 28, 214–242 (2008). https://doi.org/10.1080/02726340801921650CrossRef

Uniyal, A., Srivastava, G., Pal, A., et al.: Recent advances in optical biosensors for sensing applications: a review. Plasmonics (2023). https://doi.org/10.1007/s11468-023-01803-2CrossRefMATH

Sharma, A.K., Kaur, B.: Fiber optic SPR sensing enhancement in NIR via optimum radiation damping catalyzed by 2D materials. IEEE Photonics Technol. Lett. 30, 2021–2024 (2018). https://doi.org/10.1109/LPT.2018.2874700CrossRefMATH

Pal, A., Trabelsi, Y., Sarkar, P., et al.: Plasmonic pregnancy detector: enhancing sensitivity with SPR sensor. Opt. Quantom Electron. 56, 1404 (2024). https://doi.org/10.1007/s11082-024-07342-2CrossRef

10.

Sharma, A.K., Dominic, A., Kaur, B., Popescu, V.A.: Fluoride fiber sensor with huge performance enhancement via optimum radiative damping at Ag-Al₂O₃-graphene heterojunction on silicon. J. Lightwave Technol. 37, 5641–5646 (2019). https://doi.org/10.1109/JLT.2019.2895100CrossRefMATH

11.

Karki, B., Ansari, G., Uniyal, A., Srivastava, V.: PtSe₂ and black phosphorus employed for sensitivity improvement in the surface plasmon resonance sensor. J. Comput. Electron. 22, 106–115 (2023). https://doi.org/10.1007/s10825-022-01975-wCrossRef

12.

Mishra, A.C., Sharma, A.K., Lohia, P., Dwivedi, D.K.: Modelling and analysis of high-performing reconfigurable SPR refractive index sensor employing beryllium oxide, nickel, and BlueP/WS2 nanomaterials. Plasmonics (2023). https://doi.org/10.1007/s11468-023-02005-6CrossRef

13.

Shakya, A.K., Singh, S.: Performance analysis of a developed optical sensing setup based on the Beer–Lambert law. Plasmonics 19, 447–455 (2024). https://doi.org/10.1007/s11468-023-01979-7CrossRefMATH

14.

Srivastava, S., Singh, S., Mishra, A.C., et al.: Numerical study of titanium dioxide and MXene nanomaterial-based surface plasmon resonance biosensor for virus SARS-CoV-2 detection. Plasmonics (2023). https://doi.org/10.1007/s11468-023-01874-1CrossRefMATH

15.

Saadatmand, S.B., Shokouhi, S., Ahmadi, V., Hamidi, S.M.: Design and analysis of a flexible Ruddlesden–Popper 2D perovskite metastructure based on symmetry-protected THz-bound states in the continuum. Sci. Rep. (2023). https://doi.org/10.1038/s41598-023-49224-9CrossRefMATH

16.

Umar, A., Singh, S., Yadav, S., et al.: Numerical study of surface plasmon resonance biosensor using aluminium oxide and bismuth telluride nanomaterials for skin cancer cell detection. J. Nanoelectron. Optoelectron. (2022). https://doi.org/10.1166/jno.2022.3358CrossRefMATH

17.

Shakya, A.K., Ramola, A., Singh, S., Vidyarthi, A.: Optimized design of plasmonic biosensor for cancer detection: core configuration and nobel material coating innovation. Plasmonics (2024). https://doi.org/10.1007/s11468-024-02400-7CrossRefMATH

18.

Naik, G.V., Shalaev, V.M., Boltasseva, A.: Alternative plasmonic materials: beyond gold and silver. Adv. Mater. 25, 3264–3294 (2013). https://doi.org/10.1002/adma.201205076CrossRefMATH

19.

Fouad, S., Sabri, N., Jamal, Z.A.Z., Poopalan, P.: Enhanced sensitivity of surface plasmon resonance sensor based on bilayers of silver-barium titanate. J. Nano- Electron. Phys. 8, 2–6 (2016). https://doi.org/10.21272/jnep.8(4(2)).04085CrossRef

20.

Singh, S., Mishra, A.C., Singh, S., et al.: Theoretical study of perovskite nano material based surface plasmon resonance biosensor for cancers cell detection. Optik (Stuttg) (2023). https://doi.org/10.1016/j.ijleo.2023.171259CrossRefMATH

21.

Taya, S.A., Daher, M.G., Colak, I., Ramahi, O.M.: Highly sensitive nano-sensor based on a binary photonic crystal for the detection of mycobacterium tuberculosis bacteria. J. Mater. Sci.: Mater. Electron. 32, 28406–28416 (2021). https://doi.org/10.1007/s10854-021-07220-7CrossRef

22.

Jaiswal, L., Dwivedi, D.K., Lohia, P., et al.: Numerical study of 2D nanomaterial-based surface plasmon resonance biosensor. Plasmonics (2024). https://doi.org/10.1007/s11468-024-02225-4CrossRefMATH

23.

Saadatmand, S.B., Shokouhi, S., Ahmadi, V., Hamidi, S.M.: Metastructure engineering with Ruddlesden–Popper 2D perovskites: stability, flexibility, and quality factor trade-offs. ACS Omega 9, 24925–24932 (2024). https://doi.org/10.1021/acsomega.4c01827CrossRef

24.

Mattheiss, L.F.: Band structures of transition-metal-dichalcogenide layer compounds. Phys. Rev. B 8, 3719–3740 (1973). https://doi.org/10.1103/PhysRevB.8.3719CrossRefMATH

25.

Kalantar-zadeh, K., Ou, J.Z., Daeneke, T., et al.: Two-dimensional transition metal dichalcogenides in biosystems. Adv. Funct. Mater. 25, 5086–5099 (2015). https://doi.org/10.1002/adfm.201500891CrossRef

26.

Almawgani, A.H.M., Daher, M.G., Taya, S.A., et al.: Detection of blood plasma concentration theoretically using SPR-based biosensor employing black phosphor layers and different metals. Plasmonics 17, 1751–1764 (2022). https://doi.org/10.1007/s11468-022-01662-3CrossRef

27.

Anastasiou, E., Lorentz, K.O., Stein, G.J., et al.: Sensitivity improved SPR biosensor based on the MoS₂/graphene-aluminum hybrid structure. Sens. Actuators B Chem. 5, 1–15 (2017). https://doi.org/10.1038/nphoton.2012.262CrossRefMATH

28.

Rubio-Bollinger, G., Guerrero, R., de Lara, D.P., et al.: Enhanced visibility of MoS₂, MoSe₂, WSe₂ and black-phosphorus: making optical identification of 2D semiconductors easier. Electronics (Switzerland) 4, 847–856 (2015). https://doi.org/10.3390/electronics4040847CrossRef

29.

Shang, J., Shen, X., Cong, C., et al.: Observation of excitonic fine structure in a 2D transition-metal dichalcogenide semiconductor. ACS Nano 9, 647–655 (2015). https://doi.org/10.1021/nn5059908CrossRefMATH

30.

Sharma, A.K., Gupta, J., Basu, R.: Simulation and performance evaluation of fiber optic sensor for detection of hepatic malignancies in human liver tissues. Opt. Laser Technol. 98, 291–297 (2018). https://doi.org/10.1016/j.optlastec.2017.08.009CrossRefMATH

31.

Mishra, A.C., Singh, P.K., Lohia, P., Dwivedi, D.K.: Evanescent field absorption based fiber optic sensor using chalcogenide glasses for biological tissues detection. Sens. Lett. 17, 1–6 (2019). https://doi.org/10.1166/sl.2019.4196CrossRef

32.

Singh, R.K., Mishra, A.C., Lohia, P., Dwivedi, D.K.: Simulation for enhancement in sensitivity of chalcogenide glasses-based fibre optic evanescent absorption sensor for malignant tissue detection. Micro Nanosyst. 13, 180–185 (2020). https://doi.org/10.2174/1876402912999200527141549CrossRef

33.

Bai, J., Zhou, B.: Titanium dioxide nanomaterials for sensor applications. Chem. Rev. 114, 10131–10176 (2014)CrossRefMATH

34.

Dallorto, S., Staaks, D., Schwartzberg, A., et al.: Atomic layer deposition for spacer defined double patterning of sub-10 nm titanium dioxide features. Nanotechnology (2018). https://doi.org/10.1088/1361-6528/aad393CrossRef

35.

Vasimalla, Y., Pradhan, H.S., Pandya, R.J., et al.: Titanium dioxide-2D nanomaterial based on the surface plasmon resonance (SPR) biosensor performance signature for infected red cells detection. Plasmonics 18, 1725–1734 (2023). https://doi.org/10.1007/s11468-023-01885-yCrossRef

36.

Aliqab, K., Uniyal, A., Srivastava, G., et al.: A theoretical analysis of refractive index sensor with improved sensitivity using titanium dioxide, graphene, and antimonene grating: pseudomonas bacteria detection. Measurement (Lond) (2023). https://doi.org/10.1016/j.measurement.2023.112957CrossRef

37.

Rakic, A.D., Rakic, R., Djuriš, A.B., et al.: Optical properties of metallic films for vertical-cavity optoelectronic devices. Appl. Opt. 37, 5271–5283 (1998)CrossRefMATH

38.

Karki, B., Ramya, K.C., Sandhya Devi, R.S., et al.: Titanium dioxide, black phosphorus and bimetallic layer-based surface plasmon biosensor for formalin detection: numerical analysis. Opt Quantum Electron 54, 1–15 (2022). https://doi.org/10.1007/s11082-022-03875-6CrossRefMATH

39.

Singh, S., Remeika, J.P., Potopowicz, J.R.: Nonlinear optical properties of ferroelectric lead titanate. Appl. Phys. Lett. 20, 135–137 (1972). https://doi.org/10.1063/1.1654078CrossRef

40.

Giannios, P., Toutouzas, K.G., Matiatou, M., et al.: Visible to near-infrared refractive properties of freshly-excised human-liver tissues: marking hepatic malignancies. Sci. Rep. (2016). https://doi.org/10.1038/srep27910CrossRef

41.

Mishra, A.C., Dandapat, K., Tripathi, S.M., et al.: Modelling and analysis of chirped long-period grating inscribed in a planer optical waveguide structure for sensing applications. J. Opt. Commun. (2020). https://doi.org/10.1515/joc-2020-0128CrossRefMATH

42.

Singh, Y., Dwivedi, D.K., Lohia, P., et al.: Highly sensitive plasmonic biosensor for the detection of Chikungunya virus employing TiO₂ and BP/WS2 heterostructure. Plasmonics (2024). https://doi.org/10.1007/s11468-024-02242-3CrossRef

43.

Srivastava, D., Yadav, S., Mishra, A.C., et al.: Numerical study of photonic crystal fiber-based optical biosensor for detection of cervical cancer. J. Opt. (India) (2023). https://doi.org/10.1007/s12596-023-01254-2CrossRefMATH

44.

Sharma, A.K., Gupta, J.: Simulation and comprehensive analysis of fluoride fiber SPR sensor with multilayer variants of 2D materials (graphene and MoS₂) under optimum radiation damping in NIR. IEEE Sens. J. 19, 8775–8780 (2019). https://doi.org/10.1109/JSEN.2019.2922317CrossRefMATH

45.

Mishra, A.C., Dwivedi, D.K., Sharma, A.K., et al.: Modeling of high-performance fiber optic SPR sensor for colorectal cancer detection designed using amorphous silicon and TiO₂ layers under optimum radiation damping. IEEE Sens. J. (2024). https://doi.org/10.1109/JSEN.2024.3427414CrossRefMATH

46.

Singh, N.P., Mishra, A.C., Yadav, S., et al.: Highly sensitive SPR biosensor for malaria detection employing ZnO, Fe₂O₃, and black phosphorous. Plasmonics (2024). https://doi.org/10.1007/s11468-024-02307-3CrossRefMATH

47.

Singh, Y., Mishra, A.C., Yadav, S., et al.: High-performance plasmonic biosensor for blood cancer detection: achieving ultrahigh figure-of-merit. Plasmonics (2024). https://doi.org/10.1007/s11468-024-02429-8CrossRefMATH

Title: TiO2 and PbTiO3 assisted SPR biosensor for detection of malignancy in human-liver tissue with high sensitivity and figure of merit
Authors: Laxmi Jaiswal
Adarsh Chandra Mishra
Sapana Yadav
Pooja Lohia
D. K. Dwivedi
R. K. Yadav
Upendra Kulshrestha
Ammar M. Tighezza
M. Khalid Hossain
Publication date: 01-02-2025
Publisher: Springer US
Published in: Journal of Computational Electronics / Issue 1/2025
Print ISSN: 1569-8025
Electronic ISSN: 1572-8137
DOI: https://doi.org/10.1007/s10825-025-02277-7

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TiO₂ and PbTiO₃ assisted SPR biosensor for detection of malignancy in human-liver tissue with high sensitivity and figure of merit

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