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01-07-2022 | Review

Toxicity assessment of nanoparticles in contact with the skin

Authors: Taghrid Zaiter, Raphaël Cornu, Wassim El Basset, Hélène Martin, Mona Diab, Arnaud Béduneau

Published in: Journal of Nanoparticle Research | Issue 7/2022

Abstract

Due to their unique physicochemical properties, engineered nanoparticles (NPs) are used in numerous skin products as sunscreen, texture agents, colorant, and drug delivery systems. While the skin is considered the first line of defense against xenobiotic entrance, the small size of NPs could promote the interaction with cutaneous cells. This review investigates the fate and the toxicological effects of organic and inorganic NPs used in cosmetic and dermatology. After direct exposure to skin cells, cytotoxicity, oxidative stress, inflammatory response, and genotoxicity were reported in a dose and time-dependent manner, especially for inorganic NPs. Despite these findings, the toxicity of nanoparticles applied to a healthy skin could be questioned due to their inability, for most of them, to reach the viable epidermis. Advanced skin models and toxicity tests validated for nanomaterials should be required for a better prediction of the dermal nanotoxicity.

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Title: Toxicity assessment of nanoparticles in contact with the skin
Authors: Taghrid Zaiter
Raphaël Cornu
Wassim El Basset
Hélène Martin
Mona Diab
Arnaud Béduneau
Publication date: 01-07-2022
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 7/2022
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-022-05523-2

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