Plastic waste has been a battling environmental menace in Ghana. Since the nineteenth century, precisely in the 1970s, industries in Ghana such as food and brewing, pharmaceutical, cosmetics, and many others welcomed the use of plastic as a packaging material. Now, Ghana generates over 1 million tons of plastic waste annually. Unfortunately, the industrial effort to recycle these plastic wastes in the country is only pegged at 5%. The large piles of plastic waste end up in the streets, beaches, drains, and oceans, resulting in dire environmental challenges such as the destruction of biodiversity, climate change, poor sanitation, and visual nuisance in social spaces as well as poor health and well-being. Some Ghanaian visual artists in an attempt to salvage the situation have made giant efforts to transform plastic waste into innovative and creative artistic products. This chapter discusses the art practice of three Ghanaian artists, namely Samuel Prophask Asamoah, Rufai Zakari Jabre, and Serge Attukwei Clottey, and how their creative intuitions have contributed to helping the country in achieving seven of the sustainable development goals (SDGs) 3, 6, 11, 12, 13, 14, and 15. The chapter contends that if the Ghana government and other funding agencies support the activities of these genius Ghanaian visual artists who innovatively engage in upcycling or creative reuse of solid waste, it would not only lead to the good management of the solid waste, herein plastic waste, but also open entrepreneurial opportunities for the young and old in this period of difficult economic hardship.