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2021 | OriginalPaper | Chapter

Unfavorable Impact of the Urbanization on the Immune Antiviral Protection in Children: The Relationship with Recurrent Respiratory Infections

Authors : I. V. Nesterova, E. O. Khalturina, S. V. Kovaleva, G. A. Chudilova, V. V. Malinovskaya

Published in: Advanced Technologies for Sustainable Development of Urban Green Infrastructure

Publisher: Springer International Publishing

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Abstract

In the conditions of steadily increasing urbanization and emerging negative microclimates, there is increase the morbidity of children in megacities. The damaging effect of environmental factors causes the development of “minimal persistent inflammation” of mucosa. We had studied 55 children in age 1–8 years suffering from recurrent ARVI associated with different chronic HVI (HSV I/II, EBV, CMV, HHV VI) and chronic recurrent bacterial diseases. The comparison group was 40 conditionally healthy children, comparable by sex and age. Clinical and immunological methods: ELISA, PCR, cytofluorimetry were used. We studied 2 groups of children: 1 group – 1–4 years old (early children) and 2 group – 5–8 years old, suffering from recurrent ARVI of a high rate of frequency. Clinical and anamnestic data showed that the incidence of ARVI was in 1 group – 7–15 and in 2 groups – 7–24 or more episodes per year, and the duration of these episodes was: 7.5 and 15.8 days, respectively. In all children, repeated ARI in combination with chronic respiratory diseases with frequent exacerbations were associated with recurrent and/or mono- and mixed HVI. Comparative analysis showed that in the children from group 1 demonstrate deficient in IFN-α, serum IgA and various NG disorders. However more severe disorders in IFN-α, NK-cells, NG system were detected in group 2, which is associated with a greater age of infectious history. Our study revealed the urgency to create new approaches for targeted immunoprophylaxis for immunocompromised children living in the megapolis.

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Literature
1.
Deryusheva, A.V., Lvova, I.I., Legotina, N.S.: Program Rationale of Treatment and Prevention in Children with Frequent Respiratory Diseases. Child. infect. 16(1), 15–20 (2017)CrossRef
2.
Babachenko, I.V., Kvetnaya, A.S., Melnik, O.V., Levina, A.S.: Pathogenesis of the Formation of Frequent Respiratory Illnesses in Children Having Epstein-Barr Virus and Cytomegalovirus Infection. Infectol. J. 3(4), 67–72 (2011)
3.
Balmasova, I.P., Malova, E.S., Sepiashvili, R.I.: Viral and Bacterial Coinfections as a Global Issue of the Modern Medicine. Bull. PFUR Ser. Med. 22(1), 29–42 (2018)
4.
Baranov, A.A., Namazova-Baranova, L.S., Lobzin, Yu.V., Tatochenko, V.K., Uskov, A.N., Vakhitov, K., Pikuza, O.I., Vakhitova, L.F., Zakirova, A.M., Rizvanova, F.F.: Interferon Inductors in Prevention and Treatment of Respiratory Infections in Children. Russ. Bull. Perinatol. Pediatr. 64(3), 103–108 (2019). https://​doi.​org/​10.​21508/​1027-4065-2019-64-3-103-108
5.
Esposito, S., Michael, R.: Immunomodulation for Recurrent Respiratory Tract Infections: New Insights and Perspectives. EMJ Respir. 4(10), 2–10 (2016)
6.
Harada, Y., Kinoshita, F., Yoshida, L.M., Minh, L.N., Suzuki, M., Morimoto, K., Toku, Y., Tomimasu, K., Moriuchi, H., Ariyoshi, K.: Does respiratory Virus Coinfection Increase the Clinical Severity of Acute Respiratory Infection Among Children Infected with Respiratory Syncytial Virus? Pediatr. Infect. Dis. J. 32(5), 441–445 (2013). https://​doi.​org/​10.​1097/​INF.​0b013e31828ba08c​CrossRef
7.
Kankasova, M.N., Mokhova, O.G., Pozdeeva, O.S.: Frequently ill Children: An Infectious Disease Physician’s View. Pract. Med. 9(85), 67–71 (2014)
8.
9.
Luss, L.V.: Secondary Immunodeficiency Conditions in Children. A Clinician’s View on Prescribing the Immunomodulatory Therapy. Allergol. Immunol. Pediatry 4(55), 4–18 (2018)
10.
Kovaleva, S.V., Nesterova, I.V., Chudilova, G.A., Krutova, V.A., Aslanyan, I.E., Tulendinova, A.I., Malinovskaya, V.V., Matveevskaya, K.Z., Mitropanova, M.N.: Target immunotherapy in immunocompromised children with comorbid diseases. In: Allergy, Asthma, COPD, Immunophysiology & Norehabilitology: Innovayive Technologies. Filodiritto International Proceedings, Bologna, Italy, pp. 249–258 (2019)
11.
Kovtun, T.A., Tuteliyan, A.V., Shabalina, S.V.: Modern Ideas About Epidemiology and Etiology of Acute Respiratory Diseases of the Airways in Children. Epidemiol. Vaccinal Prev. 54(5), 41–44 (2010)
12.
Raniszewska, A., Górska, E., Kotuła, I., Stelmaszczyk-Emmel, A., Popko, K., Ciepiela, O.: Recurrent Respiratory Tract Infections in Children – Analysis of Immunological Examinations. Cent. Eur. J. Immunol. 40(2), 167–173 (2015)CrossRef
13.
14.
Nesterova, I.V., Malinovskaya, V.V., Tarakanov, V.A., Kovaleva, S.V.: Interferono- and Immunotherapy in the Practice of Treating Often and Long-Term ill Children and Adults. Capricorn Publishing, Hyattsville (2004)
15.
Lysenkova, M.Yu., Karazhas, N.V., Melekhina, E.V., Rybalkina, T.N., Veselovskiy, P.A., Burmistrov, E.M., Boshiyan, R.E., Muzyka, A.D., Gorelov, A.V.: Herpes Virus Infections in Children Having Recurrent Respiratory Diseases. Child. Infect. 17(2), 17–21 (2018)
16.
Markova, T.P.: Frequently ill Children. An Immunologist’s View. Torus Press, Moscow (2014)
17.
Savenkova, M.S., Karashtina, O.V., Shabat, M.B., Kraseva, G.N., Abramova, N.A., Kraseva, T.E.: Interferon Status and Selection of Interferon Inductors in Frequently ill Children. Child. Infect. 2, 45–51 (2016)CrossRef
18.
Nesterova, I.V.: Interferons in the Practice of a Clinician: Best Friends or Dangerous Enemies? Allergol. Immunol. 17(3), 189–191 (2016)
19.
Nesterova, I.V.: Secondary immune deficiencies and methods for correcting them in the practice of an ORL-specialist. In: Simbirtsev, A.S., Lavrinova, G.V. (eds.) Chapter 2 in the Monograph “Immunotherapy in the Practice of ENT-Specialist and Primary Care Physician”, pp. 32–97 (2018)
20.
Tataurshchikova, N.S.: Personalized Immunotherapy. In Focus, a Frequently and Long-Term Sick Child, Consilium Medicum. Pediatrics 03, 50–54 (2018)
21.
Tataurshchikova, N.S.: Acute Reparatory Disease in a Patient with Allergies, Key Participants in the Problem. How to be and What to do. Farmatek, 18(331), 23–29 (2016)
22.
Nesterova, I.V., Harina, D.V.: Two-Stage Immunorehabilitation of Early Children Age From Risk Groups for Frequent and Long-Term Return Respiratory Infections and Inflammatory Diseases. Russ. Immunol. Mag. t.12 (21).- № 4 .- C.565–571 (2018)
23.
Nesterova, I.V., Kovaleva, S.V., Chudilova, G.A., Malinovskaya, V.V.: Interferon and immunotherapy in rehabilitation of immunocompromised children having relapsing respiratory infections. In: Simbirtsev, A.S., Lavrinova, G.V. (eds.) Chapter 7 in the Monograph “Immunotherapy in the Practice of ENT-Specialist and Primary Care Physician”, St.Petersburg: Dialog (2018)
24.
Romantsov, M.G., Melnikova, IYu.: Frequently ill Children: Questions of Pharmacotherapy (A Scientific Review). Terra Medica 1, 55–69 (2014)
25.
Zaytseva, O.V.: Recurrent Respiratory Infections: Can They be Prevented? Journal “Pediatria” named after G.N. Speransky 94(2), 185–192 (2015)
26.
Yulish, E.I., Yaroshenko, S.Ya.: Persistent Herpes Virus Infections and Their Role in Morbidity of Children Belonging to the Group Having Frequent and Long-Term Illnesses. Child’s Health 7(50), 145–150 (2013)
27.
28.
Zaplatnikov, A.L., Korovina, N.A., Ghirina, A.A., Suzdalenkov, A.V., Lepiseva, I.V.: Modern Opportunities of Efficient Preventive Immunization for Acute Respiratory Infections in Health Improvement Programs for Frequently ill Children. Child. Infect. 10(1), 56–59 (2011)
29.
Karaulov, A.V.: Immunomodulators in Prevention and Treatment of Respiratory Infections in Children. Farmateka 1, 43–47 (2012)
30.
Kornienko, M.N., Karazhas, N.V., Rybalkina, T.N., Feklisova, L.V., Savitskaya, N.A.: The Role of Opportunistic Infections in Etiology of Acute Respiratory Diseases Having a Complicated Course in Frequently ill Children. Child. Infect. 11(3), 54–56 (2012)
Metadata
Title
Unfavorable Impact of the Urbanization on the Immune Antiviral Protection in Children: The Relationship with Recurrent Respiratory Infections
Authors
I. V. Nesterova
E. O. Khalturina
S. V. Kovaleva
G. A. Chudilova
V. V. Malinovskaya
Copyright Year
2021
Book
Advanced Technologies for Sustainable Development of Urban Green Infrastructure

Print ISBN: 978-3-030-75284-2

Electronic ISBN: 978-3-030-75285-9

Copyright Year: 2021

DOI
https://doi.org/10.1007/978-3-030-75285-9_16