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2016 | OriginalPaper | Chapter

Using Automatic HARDI Feature Selection, Registration, and Atlas Building to Characterize the Neuroanatomy of Aβ Pathology

Authors : Evan Schwab, Michael A. Yassa, Michael Weiner, René Vidal

Published in: Computational Diffusion MRI

Publisher: Springer International Publishing

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Abstract

The detection of white matter microstructural changes using diffusion magnetic resonance imaging (dMRI) often involves extracting a small set of scalar features, such as fractional anisotropy (FA) and mean diffusivity (MD) in diffusion tensor imaging (DTI). With the advent of more advanced dMRI techniques, such as high angular resolution diffusion imaging (HARDI), a number of mathematically inspired new scalar features have been proposed. However, it is unclear how to select the most biologically informative combinations of features for biomarker discovery. This paper proposes an automatic HARDI feature selection algorithm which is based on registering HARDI features to feature atlases for optimal clinical usability in population studies. We apply our framework to the characterization of beta-amyloid (Aβ) pathology for the early detection of Alzheimer’s disease (AD) to better understand the relationship between Aβ pathology and degenerative changes in neuroanatomy.

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Literature
1.
go back to reference Alexander, D., Pierpaoli, C., Basser, P., Gee, J.: Spatial transformation of diffusion tensor magnetic resonance images. IEEE Trans. Med. Imaging 20, 1131–1139 (2001)CrossRef Alexander, D., Pierpaoli, C., Basser, P., Gee, J.: Spatial transformation of diffusion tensor magnetic resonance images. IEEE Trans. Med. Imaging 20, 1131–1139 (2001)CrossRef
2.
go back to reference Beg, M.F., Miller, M.I., Trouvé, A., Younes, L.: Computing large deformation metric mappings via geodesic flows of diffeomorphisms. Int. J. Comput. Vis. 61(2), 139–157 (2005)CrossRef Beg, M.F., Miller, M.I., Trouvé, A., Younes, L.: Computing large deformation metric mappings via geodesic flows of diffeomorphisms. Int. J. Comput. Vis. 61(2), 139–157 (2005)CrossRef
3.
go back to reference Bloy, L., Verma, R.: Demons registration of high angular resolution diffusion images. In: IEEE International Symposium on Biomedical Imaging, pp. 1013–1016 (2010) Bloy, L., Verma, R.: Demons registration of high angular resolution diffusion images. In: IEEE International Symposium on Biomedical Imaging, pp. 1013–1016 (2010)
4.
go back to reference Caruyer, E., Verma, R.: On facilitating the use of HARDI in population studies by creating rotation-invariant markers. Med. Image Anal. 20(1), 87–96 (2014)CrossRef Caruyer, E., Verma, R.: On facilitating the use of HARDI in population studies by creating rotation-invariant markers. Med. Image Anal. 20(1), 87–96 (2014)CrossRef
5.
go back to reference Ceritoglu, C., Oishi, K., Li, X., Chou, M.C., Younes, L., Albert, M., Lyketsos, C., van Zijl, P.C.M., Miller, M.I., Mori, S.: Multi-contrast large deformation diffeomorphic metric mapping for diffusion tensor imaging. NeuroImage 47(2), 618–627 (2009)CrossRef Ceritoglu, C., Oishi, K., Li, X., Chou, M.C., Younes, L., Albert, M., Lyketsos, C., van Zijl, P.C.M., Miller, M.I., Mori, S.: Multi-contrast large deformation diffeomorphic metric mapping for diffusion tensor imaging. NeuroImage 47(2), 618–627 (2009)CrossRef
6.
go back to reference Chao, L., Decarli, C., Kriger, S., Truran, D., Zhang, Y., Laxamana, J., Villeneuve, S., Jagust, W., Sanossian, N., Mack, W., Chui, H., Weiner, M.: Associations between white matter hyperintensities and β amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS One 8(6), e65175 (2013)CrossRef Chao, L., Decarli, C., Kriger, S., Truran, D., Zhang, Y., Laxamana, J., Villeneuve, S., Jagust, W., Sanossian, N., Mack, W., Chui, H., Weiner, M.: Associations between white matter hyperintensities and β amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS One 8(6), e65175 (2013)CrossRef
7.
go back to reference Du, J., Goh, A., Qiu, A.: Large deformation diffeomorphic metric mapping of orientation distribution functions. In: Information Processing in Medical Imaging, pp. 448–462. Springer, Berlin (2011) Du, J., Goh, A., Qiu, A.: Large deformation diffeomorphic metric mapping of orientation distribution functions. In: Information Processing in Medical Imaging, pp. 448–462. Springer, Berlin (2011)
8.
go back to reference Du, J., Goh, A., Qiu, A.: Diffeomorphic metric mapping of high angular resolution diffusion imaging based on Riemannian structure of orientation distribution functions. IEEE Trans. Med. Imaging 31(5), 1021–1033 (2012)CrossRef Du, J., Goh, A., Qiu, A.: Diffeomorphic metric mapping of high angular resolution diffusion imaging based on Riemannian structure of orientation distribution functions. IEEE Trans. Med. Imaging 31(5), 1021–1033 (2012)CrossRef
9.
go back to reference Du, J., Goh, A., Qiu, A.: Bayesian atlas estimation from high angular resolution diffusion imaging (HARDI). In: Geometric Science of Information, pp. 149–157. Springer, Heidelberg (2013) Du, J., Goh, A., Qiu, A.: Bayesian atlas estimation from high angular resolution diffusion imaging (HARDI). In: Geometric Science of Information, pp. 149–157. Springer, Heidelberg (2013)
10.
go back to reference Du, J., Hosseinbor, A.P., Chung, M.K., Bendlin, B.B.: Diffeomorphic metric mapping of hybrid diffusion imaging based on BFOR signal basis. In: Information Processing in Medical Imaging, pp. 1–12. Springer, Berlin (2013) Du, J., Hosseinbor, A.P., Chung, M.K., Bendlin, B.B.: Diffeomorphic metric mapping of hybrid diffusion imaging based on BFOR signal basis. In: Information Processing in Medical Imaging, pp. 1–12. Springer, Berlin (2013)
11.
go back to reference Fuster, A., van de Sande, J., Astola, L., Poupon, C., ter Haar Romeny, B.M.: Fourth-order tensor invariants in high angular resolution diffusion imaging. In: Computational Diffusion MRI Workshop (CDMRI), MICCAI, pp. 54–63 (2011) Fuster, A., van de Sande, J., Astola, L., Poupon, C., ter Haar Romeny, B.M.: Fourth-order tensor invariants in high angular resolution diffusion imaging. In: Computational Diffusion MRI Workshop (CDMRI), MICCAI, pp. 54–63 (2011)
12.
go back to reference Geng, X., Ross, T., Gu, H., Shin, W., Zhan, W., Chao, Y.P., Lin, C.P., Schuff, N., Yang, Y.: Diffeomorphic image registration of diffusion MRI using spherical harmonics. IEEE Trans. Med. Imaging 30(3), 747–758 (2011)CrossRef Geng, X., Ross, T., Gu, H., Shin, W., Zhan, W., Chao, Y.P., Lin, C.P., Schuff, N., Yang, Y.: Diffeomorphic image registration of diffusion MRI using spherical harmonics. IEEE Trans. Med. Imaging 30(3), 747–758 (2011)CrossRef
13.
go back to reference Ghosh, A., Papadopoulo, T., Deriche, R.: Biomarkers for HARDI: 2nd & 4th order tensor invariants. In: IEEE International Symposium on Biomedical Imaging, pp. 26–29 (2012) Ghosh, A., Papadopoulo, T., Deriche, R.: Biomarkers for HARDI: 2nd & 4th order tensor invariants. In: IEEE International Symposium on Biomedical Imaging, pp. 26–29 (2012)
14.
go back to reference Ghosh, A., Papadopoulo, T., Deriche, R.: Generalized Invariants of a 4th order tensor: building blocks for new biomarkers in dMRI. In: Computational Diffusion MRI Workshop (CDMRI), MICCAI, pp. 165–173 (2012) Ghosh, A., Papadopoulo, T., Deriche, R.: Generalized Invariants of a 4th order tensor: building blocks for new biomarkers in dMRI. In: Computational Diffusion MRI Workshop (CDMRI), MICCAI, pp. 165–173 (2012)
15.
go back to reference Gur, Y., Johnson, C.R.: Generalized HARDI invariants by method of tensor contraction. In: IEEE International Symposium on Biomedical Imaging, pp. 718–721 (2014) Gur, Y., Johnson, C.R.: Generalized HARDI invariants by method of tensor contraction. In: IEEE International Symposium on Biomedical Imaging, pp. 718–721 (2014)
16.
go back to reference Hong, X., Arlinghaus, L., Anderson, A.: Spatial normalization of the fiber orientation distribution based on high angular resolution diffusion imaging data. Magn. Reson. Med. 61, 1520–1527 (2009)CrossRef Hong, X., Arlinghaus, L., Anderson, A.: Spatial normalization of the fiber orientation distribution based on high angular resolution diffusion imaging data. Magn. Reson. Med. 61, 1520–1527 (2009)CrossRef
17.
go back to reference Ma, J., Miller, M.I., Trouvé, A., Younes, L.: Bayesian template estimation in computational anatomy. NeuroImage 42(1), 252–261 (2008)CrossRef Ma, J., Miller, M.I., Trouvé, A., Younes, L.: Bayesian template estimation in computational anatomy. NeuroImage 42(1), 252–261 (2008)CrossRef
18.
go back to reference Papadopoulo, T., Ghosh, A., Deriche, R.: Complete set of invariants of a 4th order tensor: the 12 tasks of HARDI from ternary quartics. In: Medical Image Computing and Computer Assisted Intervention, pp. 233–240. Springer, Berlin (2014) Papadopoulo, T., Ghosh, A., Deriche, R.: Complete set of invariants of a 4th order tensor: the 12 tasks of HARDI from ternary quartics. In: Medical Image Computing and Computer Assisted Intervention, pp. 233–240. Springer, Berlin (2014)
19.
go back to reference Racine, A., Adluru, N., Alexander, A., Christian, B., Okonkwo, O., Oh, J., Cleary, C., Birdsill, A., Hillmer, A., Murali, D., Barnhart, T., Gallagher, C., Carlsson, C., Rowley, H., Dowling, N., Asthana, S., Sager, M., Bendlin, B., Johnson, S.: Associations between white matter microstructure and amyloid burden in preclinical Alzheimer’s disease: a multimodal imaging investigation. NeuroImage Clin. 4, 604–614 (2014)CrossRef Racine, A., Adluru, N., Alexander, A., Christian, B., Okonkwo, O., Oh, J., Cleary, C., Birdsill, A., Hillmer, A., Murali, D., Barnhart, T., Gallagher, C., Carlsson, C., Rowley, H., Dowling, N., Asthana, S., Sager, M., Bendlin, B., Johnson, S.: Associations between white matter microstructure and amyloid burden in preclinical Alzheimer’s disease: a multimodal imaging investigation. NeuroImage Clin. 4, 604–614 (2014)CrossRef
20.
go back to reference Reijmer, Y., Fotiadis, P., Martinez-Ramirez, S., Schultz, A., Reed, A., Ayres, A., Schwab, K., Rosand, J., Viswanathan, A., Johnson, K., Greenberg, S., Gurol, E.: Microstructural white matter alterations correlate with cerebral amyloid angiopathy burden and cognitive measures: a DTI/PET study. Neurology 82(10), P6.313 (2014) Reijmer, Y., Fotiadis, P., Martinez-Ramirez, S., Schultz, A., Reed, A., Ayres, A., Schwab, K., Rosand, J., Viswanathan, A., Johnson, K., Greenberg, S., Gurol, E.: Microstructural white matter alterations correlate with cerebral amyloid angiopathy burden and cognitive measures: a DTI/PET study. Neurology 82(10), P6.313 (2014)
21.
go back to reference Schwab, E., Cetingül, H.E., Afsari, B., Yassa, M.A., Vidal, R.: Rotation invariant features for HARDI. In: Information Processing in Medical Imaging. Springer, Berlin (2013)CrossRef Schwab, E., Cetingül, H.E., Afsari, B., Yassa, M.A., Vidal, R.: Rotation invariant features for HARDI. In: Information Processing in Medical Imaging. Springer, Berlin (2013)CrossRef
22.
go back to reference Tang, X., Oishi, K., Faria, A.V., Hillis, A.E., Albert, M.S., Mori, S., Miller, M.I.: Bayesian parameter estimation and segmentation in the multi-atlas random orbit model. PLoS ONE 8(6), e65591 (2013)CrossRef Tang, X., Oishi, K., Faria, A.V., Hillis, A.E., Albert, M.S., Mori, S., Miller, M.I.: Bayesian parameter estimation and segmentation in the multi-atlas random orbit model. PLoS ONE 8(6), e65591 (2013)CrossRef
23.
go back to reference Tang, X., Yoshida, S., Hsu, J., Huisman, T.A., Faria, A.V., Oishi, K., Kutten, K., Poretti, A., Li, Y., Miller, M.I.: Multi-contrast multi-atlas parcellation of diffusion tensor imaging of the human brain. PloS one 9(5), e96985 (2014)CrossRef Tang, X., Yoshida, S., Hsu, J., Huisman, T.A., Faria, A.V., Oishi, K., Kutten, K., Poretti, A., Li, Y., Miller, M.I.: Multi-contrast multi-atlas parcellation of diffusion tensor imaging of the human brain. PloS one 9(5), e96985 (2014)CrossRef
24.
go back to reference Yap, P.T., Chen, Y., An, H., Yang, Y., Gilmore, J., Lin, W., Shen, D.: SPHERE: spherical harmonic elastic registration of HARDI data. NeuroImage 55(2), 545–556 (2011)CrossRef Yap, P.T., Chen, Y., An, H., Yang, Y., Gilmore, J., Lin, W., Shen, D.: SPHERE: spherical harmonic elastic registration of HARDI data. NeuroImage 55(2), 545–556 (2011)CrossRef
25.
go back to reference Yassa, M.A., Muftuler, L.T., Stark, C.E.: Ultrahigh-resolution microstructural diffusion tensor imaging (msdti) elucidates perforant path degradation in aged humans in vivo. Proc. Natl. Acad. Sci. 107(28), 12687–12691 (2010)CrossRef Yassa, M.A., Muftuler, L.T., Stark, C.E.: Ultrahigh-resolution microstructural diffusion tensor imaging (msdti) elucidates perforant path degradation in aged humans in vivo. Proc. Natl. Acad. Sci. 107(28), 12687–12691 (2010)CrossRef
26.
go back to reference Yassa, M.A., Mattfeld, A.T., Stark, S.M., Stark, C.E.L.: Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proc. Natl. Acad. Sci. 108(21), 8873–8878 (2011)CrossRef Yassa, M.A., Mattfeld, A.T., Stark, S.M., Stark, C.E.L.: Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proc. Natl. Acad. Sci. 108(21), 8873–8878 (2011)CrossRef
Metadata
Title
Using Automatic HARDI Feature Selection, Registration, and Atlas Building to Characterize the Neuroanatomy of Aβ Pathology
Authors
Evan Schwab
Michael A. Yassa
Michael Weiner
René Vidal
Copyright Year
2016
DOI
https://doi.org/10.1007/978-3-319-28588-7_18

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