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Published in:
2013 | OriginalPaper | Chapter
Using Particle Swarm Optimization for Estimating Kinetics Parameters on Essential Amino Acid Production of Arabidopsis Thaliana
Authors : Siew Teng Ng, Chuii Khim Chong, Yee Wen Choon, Lian En Chai, Safaai Deris, Rosli M. Illias, Mohd Shahir Shamsir, Mohd Saberi Mohamad
Published in: Advances in Biomedical Infrastructure 2013
Publisher: Springer Berlin Heidelberg
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Parameter estimation is one of nine phases in modelling, which is the most challenging task that is used to estimate the parameter values for biological system that is non-linear. There is no general solution for determining the nonlinearity of the dynamic model. Experimental measurement is expensive, hard and time consuming. Hence, the aim for this research is to implement PSO into SBToolbox to obtain optimum kinetic parameters for simulating essential amino acid metabolism in plant model
Arabidopsis Thaliana
. There are four performance measurements, namely computational time, average of error rate, standard deviation and production of graph. PSO has the smallest standard deviation and average of error rate. The computational time in parameter estimation is smaller in comparison with others, indicating that PSO is a consistent method to estimate parameter values compared to the performance of SA and downhill simplex method after the implementation into SBToolbox.