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2015 | OriginalPaper | Chapter

Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain?

Authors : Leela R. L. Davies, Ajit Varki

Published in: SialoGlyco Chemistry and Biology I

Publisher: Springer Berlin Heidelberg

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Abstract

The sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) differ by a single oxygen atom and are widely found at the terminal position of glycans on vertebrate cell surfaces. In animals capable of synthesizing Neu5Gc, most tissues and cell types express both sialic acids, in proportions that vary between species. However, it has long been noted that Neu5Gc is consistently expressed at trace to absent levels in the brains of all vertebrates studied to date. Although several reports have claimed to find low levels of Neu5Gc-containing glycans in neural tissue, no study definitively excludes the possibility of contamination with glycans from non-neural cell types. This distribution of a molecule – prominently but variably expressed in extraneural tissues but very low or absent in the brain – is, to our knowledge, unique. The evolutionarily conserved brain-specific suppression of Neu5Gc may indicate that its presence is toxic to this organ; however, no studies to date have directly addressed this very interesting question. Here we provide a historical background to this issue and discuss potential mechanisms causing the suppression of Neu5Gc expression in brain tissue, as well as mechanisms by which Neu5Gc may exert the presumed toxicity. Finally, we discuss future approaches towards understanding the mechanisms and implications of this unusual finding.

Graphical Abstract

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Metadata
Title
Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain?
Authors
Leela R. L. Davies
Ajit Varki
Copyright Year
2015
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/128_2013_419